Measuring the effect of COVID-19-related night curfews in a bundled intervention within Germany.

We estimate the impact of local night curfews in Hesse, the fifth most populous federal state in Germany, on the growth of incidences of COVID-19 cases residing within the "second wave" of the pandemic. Thereby, we take advantage of the fact that all counties had the same measures in place with the only difference that some additionally had to implement night curfews due to state regulations. This allows us to identify the effect of night curfews as a salient part of a bundled intervention. In our case where different other measures are already in place, night curfews had at best a limited effect in slowing down the spread of the pandemic. The effect is not significantly different from zero.

Neural network for multi-exponential sound energy decay analysis.

An established model for sound energy decay functions (EDFs) is the superposition of multiple exponentials and a noise term. This work proposes a neural-network-based approach for estimating the model parameters from EDFs. The network is trained on synthetic EDFs and evaluated on two large datasets of over 20 000 EDF measurements conducted in various acoustic environments. The evaluation shows that the proposed neural network architecture robustly estimates the model parameters from large datasets of measured EDFs while being lightweight and computationally efficient. An implementation of the proposed neural network is publicly available.

Efficiency in COVID-19 Vaccination Campaigns-A Comparison across Germany's Federal States.

Vaccination programs are considered a central pillar of the efforts to stop COVID-19. However, vaccine doses are scarce and several organizational and logistical obstacles, such as the timing of and reserves for second shots and delivery failures, apparently slow down vaccination roll-outs in several countries. Moreover, it is an open question as to where vaccines are administered as efficiently as possible (vaccination centers, hospitals, doctor's offices, pharmacists, etc.). The first aim of our study was to systematically evaluate the efficiency of a country's vaccination campaign. The second aim was to analyze how the integration of doctors' offices into a campaign that formerly relied only on vaccination centers affected the speed of that campaign. Using data on vaccine deliveries and vaccinations given in Germany, we find considerable differences across federal states in terms of efficiency, defined as the ability to administer the most vaccinations out of a given number of available doses. Back-of-the-envelope calculations for January to May 2021 show that vaccinations would have been 3.4-6.9% higher if all federal states had adopted a similar ratio between vaccinations given and vaccines stored, as the most efficient states did. This corresponds to 1.7-3.3% of Germany's total population. In terms of our second research goal, we find evidence that the integration of doctors' offices into the vaccination campaign significantly increased the ratio of vaccinations administered out of a given stock of vaccine doses. On average, there appears to be a structural break in this ratio after doctors' offices were integrated into the vaccination campaign on 5 April 2021. On average, an additional 11.6 out of 100 available doses were administered each week compared to the period prior to that date. We conclude that there are considerable regional differences in the efficiency of the vaccination roll-out. Systematic efficiency analyses are one step to detecting inefficiencies and to identify best practices that can be adopted to eventually speed up the vaccination roll-out in a country.

Cost-effectiveness of Interferon-free therapy for Hepatitis C in Germany--an application of the efficiency frontier approach.

BACKGROUND: The approval of direct-acting antivirals for Interferon-free treatment revolutionized the therapy of chronic Hepatitis C infection. As of August 2014, two treatment regimens for genotype 1 infection received conditional approval in the European Union: Sofosbuvir and Ribavirin for 24 weeks and Sofosbuvir and Simeprevir with or without Ribavirin for 12 weeks. We aim to analyze the cost-effectiveness of both regimens in Germany. METHODS: We set up a Markov model with a lifetime horizon to simulate immediate treatment success and long-term disease progression for treatment-naive patients. The model analyzes both short-term and long-term costs and benefits from the perspective of the German Statutory Health Insurance. We apply the efficiency frontier method, which was suggested by German Institute for Quality and Efficiency in Health Care for cost-effectiveness analysis in Germany. RESULTS: The efficiency frontier is defined by dual therapy and first generation direct-acting antiviral Boceprevir, yielding a maximum of € 1,447.69 per additional percentage point of sustained virologic response gained. Even without rebates, Sofosbuvir/Simeprevir is very close with € 1,560.13 per additional percentage point. It is both more effective and less expensive than Sofosbuvir/Ribavirin. CONCLUSIONS: In addition to higher sustained virologic response rates, new direct-acting antivirals save long-term costs by preventing complications such as liver cirrhosis, hepatocellular carcinoma and ultimately liver transplants, thereby offsetting part of higher drug costs. Our findings are in line with the guidance published by German Society for Gastroenterology, Digestive and Metabolic Diseases, which recommends Sofosbuvir/Simeprevir for Interferon ineligible or intolerant patients.

Real time electron tunneling and pulse spectroscopy in carbon nanotube quantum dots.

We investigate a quantum dot (QD) in a carbon nanotube (CNT) in the regime where the QD is nearly isolated from the leads. An aluminum single electron transistor (SET) serves as a charge detector for the QD. We precisely measure and tune the tunnel rates into the QD in the range between 1 kHz and 1 Hz, using both pulse spectroscopy and real-time charge detection, and measure the excitation spectrum of the isolated QD.