High-resolution temporal gravity field data products: Monthly mass grids and spherical harmonics from 1994 to 2021.

Since April 2002, Gravity Recovery and Climate Experiment (GRACE) and GRACE-FO (FollowOn) satellite gravimetry missions have provided precious data for monitoring mass variations within the hydrosphere, cryosphere, and oceans with unprecedented accuracy and resolution. However, the long-term products of mass variations prior to GRACE-era may allow for a better understanding of spatio-temporal changes in climate-induced geophysical phenomena, e.g., terrestrial water cycle, ice sheet and glacier mass balance, sea level change and ocean bottom pressure (OBP). Here, climate-driven mass anomalies are simulated globally at 1.0° × 1.0° spatial and monthly temporal resolutions from January 1994 to January 2021 using an in-house developed hybrid Deep Learning architecture considering GRACE/-FO mascon and SLR-inferred gravimetry, ECMWF Reanalysis-5 data, and normalized time tag information as training datasets. Internally, we consider mathematical metrics such as RMSE, NSE and comparisons to previous studies, and externally, we compare our simulations to GRACE-independent datasets such as El-Nino and La-Nina indexes, Global Mean Sea Level, Earth Orientation Parameters-derived low-degree spherical harmonic coefficients, and in-situ OBP measurements for validation.

Extramedullary myeloma in ectopic parathyroid adenoma: A case report.

Extramedullary myeloma, a subgroup of multiple myeloma, is a rare condition characterised by extra-skeletal infiltration of clonal plasma cells. Although parathyroid adenoma's co-morbidity with multiple myeloma is common, extramedullary myeloma, an ectopic parathyroid adenoma has not been reported in the literature. This is the first study in literature that presents extramedullary myeloma that infiltrated ectopic parathyroid adenoma in the mediastinum after multiple myeloma treatment. In its course of relapse, the extramedullary myeloma created mass effect and no laboratory findings were present due to its non-secretory nature.

Gastric mixed adeno-neuroendocrine carcinoma with a large cell neuroendocrine component A case reports.

Digestive system carcinomas containing a neuroendocrine and an exocrine component are classified as mixed adenoneuroendocrine carcinomas(manec), as one of the component represents at least 30% of the whole lesion. We herein aim to contribute to literature by presenting our rare case of gastric manec. A 58-year-old male patient had a 3 cm mass placed in the antrum in his gastroscopy. The biopsy result was signet ring cell carcinoma. After that total gastrectomy with d2 lymph node dissection and roux-en-y oesophagojejunostomy was performed. The histopathology result was signet ring cell and mucinous adenocarcinoma with large cell neuroendocrine carcinoma component(manec). Manec, a rare type of biphasic tumor, usually has a poor prognosis regardless of its stage and location. This behavior is thought to be caused by the neuroendocrine component. It is vital to know the histopathology of the tumor in order to provide certain standards diagnosis and treatment management. KEY WORDS: Gastric cancer, MANEC, Mixed adenoneuroandocrine cancer.

The Evaluation of Serum Copeptin Levels and Some Commonly Seen Thrombophilic Mutation Prevalence in Acute Pulmonary Embolism.

Acute pulmonary embolism (PE) is a common, emergent condition and may affect a large number of patients. Copeptin has been indicated to be a sensitive biomarker of arginine vasopressin release, and has diagnostic and prognostic value in various clinical conditions. Genetic mutations are considerable components of thrombophilic diseases, and factor II gene G20210A, (FII20210A), factor V Leiden (FVL, G1691A) and methylenetetrahydrofolate reductase gene C677T (MTHFR677T) single nucleotide polymorphisms are the most common mutations of thrombophilic diseases. In this study, serum copeptin levels were determined in patients with PE and healthy controls, and the results were discussed. The prevalence of some commonly seen thrombophilic mutations was also evaluated in patients with PE. The study included 32 patients (18 male, 14 female) with PE and 24 (13 male, 11 female) age- and gender-matched healthy controls. A significant difference in serum copeptin levels was determined between the patient and control groups (8.58 ± 4.42 and 4.07 ± 1.02 pmol/L, respectively). Heterozygous mutant genotype for FII20210A and heterozygous mutant genotype for FVL were observed in 3.1 and 9.4% of patients, respectively. Mutant genotype of 49% was determined for MTHFR677T mutations. It was concluded that copeptin may have diagnostic value for PE.