RESUMO
T lymphocyte subsets in a positive Kveim reaction and sarcoid tissue lesions as well as peripheral blood from 16 patients with sarcoidosis were evaluated with monoclonal antibodies. The data demonstrate a redistribution of T cells from the blood to the specifically involved tissues with granulomas, i.e., sarcoid tissue lesions and positive Kveim reaction. These cells express CD2+, CD4+ phenotype as demonstrated by high CD4/CD8 ratios at the sites of positive Kveim reaction and sarcoid tissue lesions with respect to blood.
Assuntos
Teste de Kveim , Sarcoidose/imunologia , Subpopulações de Linfócitos T , Adulto , Relação CD4-CD8 , Feminino , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Sarcoidose/patologiaRESUMO
Eleven separate three-month courses of cyclosporin A, an oral solution 10 mg/kg/day, were administered to eight patients with Behçet's disease with sight-threatening posterior uveitis. It was found to be effective in arresting the inflammatory activity in the eye as well as the mucocutaneous lesions of Behçet's disease. Improvement in visual acuity was observed within one week of starting therapy. Severe exacerbations in the ocular and mucocutaneous lesions occurred on withdrawal of the drug. At this dosage side effects included hirsutism in all women, and a slight rise of serum bilirubins in two patients and of blood urea in one patient. The latter two conditions responded rapidly to dose adjustment.
Assuntos
Síndrome de Behçet/tratamento farmacológico , Ciclosporinas/uso terapêutico , Adulto , Ciclosporinas/administração & dosagem , Ciclosporinas/efeitos adversos , Feminino , Hirsutismo/induzido quimicamente , Humanos , Masculino , Testes Cutâneos , Síndrome de Abstinência a Substâncias , Uveíte/tratamento farmacológico , Acuidade VisualRESUMO
In a prospective study of 150 patients with Behçet's disease, significant associations were shown between CRP positivity and the presence of erythema nodosum (p less than 0.02) and acute thrombophlebitis (p less than 0.05) and between ESR and erythema nodosum (p less than 0.01), acute thrombophlebitis (p less than 0.001), and acute arthritis (p less than 0.01). Mucocutaneous, ocular, or central nervous system activities did not show significant associations with these indices of inflammation. In 50 patients in whom quantitative CRP determinations were performed, clinical disease activity was accompanied by slight to moderate increases in CRP and ESR.
