RESUMO
Pulmonary artery intimal sarcoma (PAIS) is a rare and aggressive malignancy originating from the intimal layer of the pulmonary artery with poor prognosis due to its aggressive nature. The management of PAIS poses both diagnostic and therapeutic challenges. It presents with nonspecific symptoms and is often misdiagnosed as pulmonary embolism. While surgical resection is the primary treatment modality, the role of adjuvant chemotherapy and radiotherapy remains uncertain. However, given the high recurrence rate, adjuvant chemotherapy and/or radiotherapy have been utilized in a limited number of case reports. We present the case of a 46-year-old woman who was diagnosed with PAIS and underwent surgical resection followed by adjuvant chemotherapy (ChT) and radiotherapy (RT), demonstrating good tolerance to this multimodal treatment approach.
RESUMO
The inward depolarization-activated current of the salivary gland cell membrane of the chironomus larva has been registered by the voltage-clamp method under conditions of the intracellular dialysis in the presence of the calcium transmembrane gradient only. An activation threshold of the current is about -50 mV, the current maximum is under -10 mV, reversion up to +10 mV leads to the current reduction. An increase in the extracellular Ca2+ concentration causes current amplification; the current decreases under the influence of verapamil, chlorpromazine, Mn2+ and Co2+. These results could indicate the existence of potential-dependent calcium channels in the secretory cell membrane.
