Perioperative dexketoprofen or lornoxicam administration for pain management after major orthopedic surgery: a randomized, controlled study.

OBJECTIVE: Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended for multimodal postoperative pain management. The purpose of this study was to evaluate the postoperative pain relief and opioid-sparing effects of dexketoprofen and lornoxicam after major orthopedic surgery. METHODS: After obtaining ethical committee approval and informed consent, 120 patients undergoing elective hip or knee replacement under general anesthesia were randomized to receive two intravenous injections of 50 mg dexketoprofen (GD), 8 mg lornoxicam (GL) or saline as placebo (GP) intravenously. Postoperatively, patient-controlled analgesia (PCA) morphine was started as a 0.01 mg.kg-1 bolus dose, with lockout time of 10 minutes without continuous infusion. Pain assessment was made using the Visual Analogue Scale (VAS) at rest or during movement at postoperative 1, 2, 4, 6, 8, 12, and 24 hours. RESULTS: The three groups were similar in terms of age, gender, American Society of Anesthesiologists (ASA) class, number of patients who underwent hip or knee surgery, weight, height, and operation duration. Patients in GD and GL demonstrated significantly reduced pain scores at rest and active motion compared to GP, with lower scores in the dexketoprofen group. Patients in GD and GL used significantly less morphine in the postoperative period compared to GP. The total morphine consumption of patients in GD was lower than in GL. CONCLUSION: Intravenous application of 50 mg dexketoprofen twice a day and 8 mg lornoxicam twice a day improved analgesia and decreased morphine consumption following major orthopedic surgery. When the two active drugs were compared, it was found that dexketoprofen was superior to lornoxicam in terms of analgesic efficacy and opioid consumption.

Effects of prone and jackknife positioning on lumbar disc herniation surgery.

BACKGROUND: Intra-abdominal hypertension due to surgical position increases bleeding at the surgical site. In this study, we evaluated the impact of prone and jackknife position on intra-abdominal pressure (IAP), lung mechanics, blood loss at the surgical site, and duration of the surgical procedure on lumbar disc operations. METHODS: Forty patients operated for single-space lumber disc herniation were included in our study. All patients were ASA I-II and 18 to 70 years old. Patients who had undergone previous spinal surgery, were on anticoagulant or anti-aggregant therapy, had hypertension, cardiac, respiratory, liver, or renal disorders, and were obese (Body Mass Index >35 kg/m²) were excluded. Patients were randomly assigned to either the prone or the jackknife position for surgery. Differences in lung mechanics, IAP, and surgical-site blood loss were calculated in both patient groups. Changes in pulmonary and abdominal pressure levels were measured both in face-up and down positions. RESULTS: Bleeding at the surgical site (prone: 180.0±100.0 mL, jackknife: 100.0±63.6 mL, P=0.018) and IAP (prone: 11.0±3.0 mm Hg, jackknife: 8.0±2.0 mm Hg, P=0.006) were significantly reduced when patients were in the jackknife position. Operating time was approximately 40 minutes shorter in the jackknife position group, although this difference was not significant. CONCLUSIONS: The jackknife position causes less IAP elevation and less surgical site bleeding compared with the prone position. The jackknife position is the preferred choice for single-level lumbar disc surgery in healthy, nonobese patients.