RESUMO
The effects of two Pseudomonas aeruginosa bacteriophages, vB-Pa 4 and vB-Pa 5, on the formation and development of biofilms of six polyresistant hospital strains of P. aeruginosa have been investigated. Pretreatment of bacteriophages prevented the formation or almost completely prevented the growth of adequate biofilms. The biofilms that had already formed were partially or completely destroyed after phage treatment. The results demonstrate the prospects of using isolated bacteriophages of P. aeruginosa to destroy biofilms and prevent their formation.
Assuntos
Biofilmes/crescimento & desenvolvimento , Fagos de Pseudomonas/crescimento & desenvolvimento , Pseudomonas aeruginosa/fisiologia , Pseudomonas aeruginosa/virologiaRESUMO
Currently large numbers of genetic markers that are closely linked to the development of cardiovascular diseases and obesity are identified. The aim of our study was the study of polymorphism Gln27Glu ß2-adrenergic receptor gene as a possible factor in the pathogenesis of obesity in patients with coronary heart disease. We conducted a comprehensive survey of 337 patients with coronary heart disease. All patients were divided into two groups according to the presence of obesity: the first group - patients with coronary artery disease with normal body weight (n=115), the second group - patients with coronary heart disease and obesity (n=222). The control group consisted of 35 healthy people. It was established that the presence of the G allele and genotype G/G Gln27Glu ß2-adrenergic receptor gene are at risk of development and progression of obesity in patients with coronary heart disease.
