RESUMO
Study of physicochemical properties of lipids in the donor blood and blood of patients with fibroma and uterus cancer showed that the progress of pathological processes may lead to the rise of peroxidation and peroxide accumulation, phospholipid balance disturbance, that causes drastic changes in biomembranes. As a result of this the disturbance of the structure and change in the functional activity of the membranes take place.
Assuntos
Leiomioma/sangue , Peroxidação de Lipídeos , Fosfolipídeos/sangue , Neoplasias Uterinas/sangue , Adulto , Ácidos Graxos/sangue , Feminino , Humanos , Pessoa de Meia-IdadeAssuntos
Fosfatase Ácida/metabolismo , Membranas Intracelulares/enzimologia , Lisossomos/enzimologia , Animais , Antracenos , Benzo(a)pireno , Colesterol/metabolismo , Membranas Intracelulares/efeitos dos fármacos , Fígado/efeitos dos fármacos , Fígado/enzimologia , Neoplasias Hepáticas Experimentais/induzido quimicamente , Neoplasias Hepáticas Experimentais/enzimologia , Lisossomos/efeitos dos fármacos , Metilcolantreno , Ratos , Marcadores de SpinRESUMO
Thermoinduced structural transitions in lyzosome membranes and lipids during experimental cancerogenesis were considered. Unlike lipid aqeous systems the structural transitions in lipids were investigated in inside out turned with hydrophobic side vesicles in apolar and aproton solvent. Relationship between the structure change and the function of lyzosome membranes is discussed.