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1.
Fundam Clin Pharmacol ; 24(2): 233-7, 2010 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-19758334

RESUMO

Some pharmaceutical tablets have an appearance that resembles that of ecstasy (a logo and often a name referring to it, a given shape and/or a colour). These are sometimes sold in the street as 'ecstasy'. In order to assess the knowledge of this phenomenon, surveys were conducted among designer drug users (DDUsers), pharmacists and pharmaceutical firms. Three surveys were conducted: the first one was conducted among DDUsers by means of an anonymous questionnaire; the second one consisted of a 1-month postal survey within a network of 155 community pharmacies in the Aquitaine region, Southwestern France and the third one consisted of a postal questionnaire sent to 71 pharmaceutical firms. Nineteen users, 77 pharmacists and 25 pharmaceutical firms participated in the surveys. All DDUsers knew the existence of what they call ecstasy 'swindles', but less than one quarter of the pharmacists and one third of pharmaceutical firms were aware of the potential recreational and involuntary misuse of medicines. The phenomenon of 'swindle' in the illicit market is not new. However, the sale of medicines because of their appearance or logo seems to be quite rare. In order to limit this diversion, prevention should be reinforced. In addition, recommendations on the appearance of medicine tablets should be set up by regulatory agencies in charge of medicine approval.


Assuntos
Controle de Medicamentos e Entorpecentes , Drogas Ilícitas/provisão & distribuição , N-Metil-3,4-Metilenodioxianfetamina/provisão & distribuição , Adolescente , Adulto , Crime/prevenção & controle , Indústria Farmacêutica/métodos , Feminino , França , Humanos , Masculino , Farmacêuticos/psicologia , Medicamentos sob Prescrição/normas , Transtornos Relacionados ao Uso de Substâncias/prevenção & controle , Inquéritos e Questionários , Comprimidos , Adulto Jovem
2.
Am J Infect Control ; 34(8): 520-5, 2006 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-17015158

RESUMO

The reservoir for hospital-acquired Legionnaires' disease has been shown to be the potable water distribution system. The objectives of the present study were as follows: (1) to examine the possible relationship between physical-chemical characteristics of water such as temperature, pH, hardness, conductivity, and residual chlorine and the presence of amoebae as growth-promoting factors for Legionella species and (2) to determine eradication measures for water distribution systems to seek ways of reducing the risk of legionellosis. Ten hospitals in southwest France took part in this study. Water samples were collected from 106 hot water faucets, showers, hot water tanks, and cooling towers. Two analyses were performed to analyze the association between water characteristics and (1) the presence of Legionella species and (2) the proliferation of Legionella species. Of the 106 water samples examined, 67 (63.2%) were positive for Legionella species. Amoebae were detected in 73 of 106 (68.9%) samples and in 56 of 67 (86.6%) Legionella species-positive samples (P < 10(-6)). In these positive samples, conductivity was lower than 500 microOmega(-1).cm(-1) in 58.2% (P = .026), temperature was below 50 degrees C in 80.6% (P = .004), and hardness was significantly higher (P = 002) than in Legionella species-negative samples. Neither Legionella species nor amoebae were isolated from any sampling point in which the water temperature was above 58.8 degrees C. Multivariate analysis shows that high hardness and presence of amoebae were strongly correlated statistically with the presence of Legionella when showers, tanks, pH, and temperature promoted their proliferation. This study shows the importance of water quality evaluation in assessing environmental risk factors and in selecting the most appropriate prevention and control measures in hospital water systems.


Assuntos
Amoeba/isolamento & purificação , Legionella/isolamento & purificação , Microbiologia da Água , Água/química , Amoeba/crescimento & desenvolvimento , Animais , Cloro/análise , Infecção Hospitalar/prevenção & controle , Condutividade Elétrica , França , Hospitais , Humanos , Concentração de Íons de Hidrogênio , Controle de Infecções/métodos , Legionella/crescimento & desenvolvimento , Legionelose/prevenção & controle , Análise Multivariada , Estatística como Assunto , Temperatura
3.
Am J Infect Control ; 32(8): 441-4, 2004 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-15573049

RESUMO

BACKGROUND: Use of protective devices has become a common intervention to decrease sharps injuries in the hospitals; however few studies have examined the results of implementation of the different protective devices available. OBJECTIVE: To determine the effectiveness of 2 protective devices in preventing needlestick injuries to health care workers. METHODS: Sharps injury data were collected over a 7-year period (1993-1999) in a 3600-bed tertiary care university hospital in France. Pre- and postinterventional rates were compared after the implementation of 2 safety devices for preventing percutaneous injuries (PIs) related to phlebotomy procedures. RESULTS: From 1993 to 1999, an overall decrease in the needlestick-related injuries was noted. Since 1996, the incidence of phlebotomy-related PIs has significantly decreased. Phlebotomy procedures accounted for 19.4% of all percutaneous injuries in the preintervention period and 12% in the postintervention period (RR, O.62; 95% CI, 0.51-0.72; P < .001). Needlestick-related injuries incidence rate decreased significantly after the implementation of the 2 safety devices, representing a 48% decline in incidence rate overall. CONCLUSIONS: The implementation of these safety devices apparently contributed to a significant decrease in the percutaneous injuries related to phlebotomy procedures, but they constitute only part of a strategy that includes education of health care workers and collection of appropriate data that allow analysis of residuals percutaneous injuries.


Assuntos
Ferimentos Penetrantes Produzidos por Agulha/prevenção & controle , Flebotomia/instrumentação , Equipamentos de Proteção , Pessoal de Saúde , Humanos , Flebotomia/tendências , Fatores de Tempo
4.
J Clin Microbiol ; 40(8): 3032-4, 2002 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-12149371

RESUMO

Four patients in an oncology ward developed Bacteroides fragilis bacteremia over a 12-day period. Cross-infection between two of them, due to an imipenem-resistant strain, was demonstrated by epidemiological investigation and genotypic typing methods (arbitrarily primed PCR fingerprinting and nucleotide sequencing of the cfiA genes and upstream IS1186/IS1168 elements).


Assuntos
Proteínas de Bactérias , Bacteroides fragilis/classificação , Bacteroides fragilis/efeitos dos fármacos , Cateterismo Venoso Central/efeitos adversos , Infecção Hospitalar/microbiologia , Imipenem/farmacologia , Tienamicinas/farmacologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Bacteriemia/epidemiologia , Bacteriemia/microbiologia , Técnicas de Tipagem Bacteriana , Infecções por Bacteroides/epidemiologia , Infecções por Bacteroides/microbiologia , Bacteroides fragilis/genética , Infecção Hospitalar/epidemiologia , DNA Bacteriano/análise , Farmacorresistência Bacteriana , Feminino , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Dados de Sequência Molecular , Neoplasias/complicações , Análise de Sequência de DNA , beta-Lactamases/genética
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