[Clinico-morphological comparisons in patients with chronic glomerulonephritis and elevated arterial pressure]. / Kliniko-morfologicheskie sopostavleniia u bol'nykh khronicheskim glomerulonefritom s povyshennym arterial'nym davleniiem.

The study assessed functional condition and restructuring of renal tissues, correlations between some clinical and morphological parameters in 250 patients suffering from chronic glomerulonephritis (CGN) with secondary hypertension (SH) and in 47 CGN patients with isolated urinary syndrome (IUS). Mesangioproliferative glomerulonephritis (MSPG) was diagnosed in 173 patients (143 with SH, 30 with IUS), membrano-proliferative glomerulonephritis (MPG) in 69 (56 with SH and 13 with IUS), membranous glomerulonephritis in 37 patients (33 with SH, 4 with IUS), focal-segmentary with SH in 11 and minimal glomerulonephritis in 7 patients. The comparison revealed significant differences in arterial pressure (AP) and more severe renal lesions in SH than in IUS. The analysis of renal tissue restructuring showed SH patients to develop vascular and tubulointerstitial disorders along with glomerular hyalinosis indicative of AP rise with progressing sclerotic involvement specific for various morphological forms. This is confirmed by a significant correlation between glomerular hyalinosis and AP in MSPG with SH and MPG with SH, while in other morphological forms these are absent. The results suggest dissimilar mechanisms of SH progression in various CGN morphological patterns.

[The transport of sodium, water and active osmotic substances in different parts of the nephron of patients with chronic glomerulonephritis and hypertension]. / Transport natriia, vody i osmoticheskikh aktivnykh veshchestv v razlichnykh uchastkakh nefrona u bol'nykh khronicheskim glomerulonefritom i gipertonicheskoi bolezn'iu.

The lithium test was conducted to evaluate transport of water, sodium and osmotic active substances in 46 chronic glomerulonephritis (CG) patients. Sixteen CG patients entered group 1. All of them had secondary hypertension (SH). Twelve CG patients with SH symptoms of moderate reduction of endogenic creatinine clearance were assigned to group 2. Twelve patients of group 3 had CG and isolated urinary syndrome. Group 4 consisted of 6 patients with essential hypertension. As shown by the test, association of SH and CG is not an essential factor for renal transport of sodium, water and electrolytes. Some shifts in the transport in group 2 are attributed to reduced number of functioning nephrons. The tendency to enhanced lithium clearance was registered in group 4. This may reflect an increased supply of sodium, water and osmotic active substances to the uriniferous tubules.

[The morphofunctional parallels in arterial hypertension in patients with chronic glomerulonephritis]. / Morfofunktsional'nye paralleli pri arterial'noi gipertonii u bol'nykh khronicheskim glomerulonefritom.

A study was made of the structural rearrangement of renal tissues in intravital nephrobiopsy specimens and of the functioning of the renin-angiotensin-aldosterone system and kallikrein-synthetic function in patients with mesangioproliferative (MSPGN) and membranous proliferative glomerulonephritis (MPGN). The morphological changes were revealed. The patients with associated MSPGN and secondary hypertension (SH) mostly demonstrated emptying and hyalinosis of arteries, whereas those with associated MPGN and SH manifested for the most part the derangement of the tubulointerstitial structures. In patients with MPGN, the levels of total renin (TR) and inactive renin (IR) were significantly higher than in those suffering from MSPGN. This can be regarded as risk factor of earlier development of SH. In MPGN patients, the content of TR and IR as well as that of active renin (AR) did not depend on the clinical pattern of chronic glomerulonephritis. As compared to MSPGN patients with isolated urinary syndrome, those with associated MSPGN and SH had a higher AR level, which agreed well with systolic and mean arterial pressure. Apparently, the latter one is implicated in the mechanism of SH in MSPGN. In associated MPGN and SH, kallikreinuria was found to be lowest, which may be the consequence of tubulointerstitial lesions. Discoordination of the renin-angiotensin and kallikrein systems is likely to be one of the causes of earlier formation and severe course of SH in the morphological pattern under consideration.

[The morphofunctional parallels in arterial hypertension in patients with chronic glomerulonephritis]. / Morfofunktsional'nye paralleli pri arterial'noi gipertensii u bol'nykh khronicheskim glomerulonefritom.

The restructure of renal tissue in intravital nephric biopsy specimens, renin-angiotensin-aldosterone together with kallikrein synthetic functions were studied and compared in patients with mesangioproliferative and membranoproliferative glomerulonephritis (MsPGN and MPGN). The characteristics of the morphological changes were defined. In MsPGN with secondary hypertension (SH), nephronic wasting and hyalinosis of arteries were mostly detectable whereas MPGN with SH was primarily marked by the derangement of the tubulointerstitial structures. In MPGN, the levels of total and inactive renin (TR and IR) were significantly higher than in MsPGN. This can be regarded as risk factor of early development of SH. The content of TR and IR and in addition that of active renin (AR) in MRGN did not depend on the clinical form of chronic glomerulonephritis. As compared to MsPGN with an isolated urinary syndrome, in MsPGN with SH, AR was prevalent, while its level correlated well with systolic and the mean arterial pressure. AR may be implicated in the mechanism of SH in MsPGN. In MPGN with SH, kallikreinuria was found to be extremely low, which may be consequent to tubulointerstitial injuries. The discoordination of the renin-angiotensin and kallikrein system may be one of the causes of earlier formation and the grave course of SH in the morphological pattern under consideration.

[Development cycle of cattle sarcosporidia]. / O tsikle razvitiia sakosporidii krupnogo rogatogo skota.

To establish the circulation of bovine sarcosporidia among wild animals of Uzbekistan foxes and young wolves were fed with bovine hearts and oesophaguses containing cysts of Sarkocystis bovicanis (= S. fusiformis). These animals were proved to be the final hosts of this species in nature. The prepatent period of S. bovicanis was found to be 7-8 and 7-9 days in foxes and young wolves, respectively and the patent one 33 and 28-34 days, respectively.