[Mammary secretion: retrospective study of diagnostic and therapeutic problems]. / La mammella secernente: studio retrospettivo di problemi diagnostici e terapeutici.

Nipple secretion is an important clinical symptom in the context of breast pathology second only, in terms of incidence and diagnostic role, to the presence of a mammary nodule. Its importance derives from its possible association with cancer (from 3% to 47%) of which it may be the earliest sign, even if it is most often in relation to a benign pathology. The authors report their experience from 1988 to the present in 60 cases of mammary secretion out of 1200 patients attending the clinic.

[Experience with more than 200 cases of breast biopsy after preoperative spatial localization without radiostereotaxic equipment]. / Esperienze in oltre 200 casi di biopsia mammaria previa localizzazione spaziale pre-chirurgica senza sistema radiostereotassico.

The use of mammography as a screening examination has considerably increased our ability to detect non-palpable breast lesions less than 1 cm phi. A conclusive diagnosis frequently requires surgical biopsy. However, breast lesions can be localized prior to surgical biopsy by placing a wire in the lesion, with/without the use of stereotaxic equipment. Our method for lesion localization consisted in acquiring two orthogonal radiographs (cranio-caudal and latero-lateral) centered on the nipple. We used 20-21 G needles, 6-10 cm long, with curved-end wire. Mammographic findings possibly suggesting cancer were: microcalcifications, nodules, spiculated opacities, and architectural distortions. From January 1987 to January 1990, 223 patients were submitted to needle localization of breast lesions under mammographic guidance and without stereotaxic equipment. Sixty-seven cases (30%) were positive for malignancy, with a 2.3:1 benign/malignant ratio. Patients' age ranged 30-70 years, but most of them were 50-60 years old. No significant complications were observed: in one case only the hook wire broke, within breast parenchyma, which was at any rate resected together with the surgical specimen.

[The Peutz-Jeghers syndrome. Study of 2 familial cases]. / La sindrome di Peutz-Jeghers. Considerazioni su due casi familiari.

Two new familial cases of Peutz-Jeghers syndrome are reported. The cases present a number of original aspects with regard to anomalous transmission of the defect, the common finding of a single ileal polyp and associated malformations in the first of the two cases. The clinical aspects of the disease are discussed together with the histology of the polyps in relation to their possibility or otherwise of degenerating. Finally, the various surgical techniques indicated for the treatment of this rare condition are examined.