RESUMO
The influence of the calcium-entry blockers, verapamil, nifedipine and diltiazem on hydrochlorothiazide-induced diuresis was determined in hydrated conscious rats. Nifedipine significantly inhibited hydrochlorothiazide-induced 5-h excreted urine volume and urinary sodium with little effect on potassium excretion. Both verapamil and diltiazem significantly enhanced urinary sodium excretion with no effect on either urine volume or potassium excretion. These results are of interest in view of the current use of nifedipine as an anti-hypertensive agent, alone or in combination with a thiazide diuretic.
Assuntos
Bloqueadores dos Canais de Cálcio/farmacologia , Diurese/efeitos dos fármacos , Hidroclorotiazida/antagonistas & inibidores , Animais , Diltiazem/farmacologia , Feminino , Nifedipino/farmacologia , Potássio/urina , Ratos , Ratos Endogâmicos , Sódio/urina , Verapamil/farmacologiaRESUMO
The influence of the calcium-entry blockers, verapamil, nifedipine and diltiazem on hydrochlorothiazide-induced diuresis was determined in hydrated conscious rats. Nifedipine significantly inhibited hydrochlorothiazide-induced 5-h excreted urine volume and urinary sodium with little effect on potassium excretion. Both verapamil and diltiazem significantly enhanced sodium excretion with no effects on either urine colume or potassium excretion. These results are of interest in view of the current use of nifedipine as an anti-hypertensive agent, alone or in combination with a thiazide diuretic
Assuntos
Ratos , Animais , Feminino , Bloqueadores dos Canais de Cálcio/farmacologia , Diurese/efeitos dos fármacos , Hidroclorotiazida/antagonistas & inibidores , Potássio/urina , Sódio/urinaRESUMO
The effects of the aqueous extract of Astronium urundeuva Engl. on aspirin and restraint plus histamine-induced ulceration in rats are described. The extract significantly inhibited aspirin-induced gastric lesions as well as restraint plus histamine-induced ulceration in rats.
Assuntos
Úlcera Péptica/tratamento farmacológico , Plantas Medicinais , Animais , Aspirina , Ácido Gástrico/metabolismo , Histamina , Úlcera Péptica/etiologia , Extratos Vegetais/uso terapêutico , Ratos , Ratos Endogâmicos , Restrição FísicaRESUMO
The effects of the aqueous extract of Astronium urundeuva Engl. on aspirin and restraint plus hustmine-induced ulceration in rats are described. The extract significantly inhibited aspirin-induced gastric lesions as well restraint plus histamine-induced ulceration in rats
Assuntos
Ratos , Animais , Plantas Medicinais , Úlcera Péptica/tratamento farmacológico , Ácido Gástrico , Aspirina , Histamina , Extratos Vegetais/uso terapêutico , Ratos Endogâmicos , Restrição Física , Úlcera Péptica/etiologiaRESUMO
Cholinesterase activity was detected in the ascitic fluid of Ehrlich tumour and studied in a comparative manner in relation to that found in mice plasma. Enzymes from both sources were characterized with respect to optimum pH, substrate concentration and quinidine inhibition. After gel filtration by Sephadex G-200 and Sepharose 6B, two enzyme forms were observed in ascitic fluid as well as in mice plasma: a large form (L) and a small form (S) presenting molecular weights of 191 000, and 224 000 daltons for L forms and 71 000 and 69 000 daltons for S forms respectively. Concanavalin A interacts with both molecular forms, suggesting a glycoprotein nature for these enzymes.
