[Endogenous sex hormone testosterone and haemostatic factors in young men after myocardial infarction].

OBJECTIVES: To compare levels of haemostatic factors and sex hormones in young men after myocardial infarction, to study relationship between sex hormones and factors of hemostasis. METHODS: We studied 32 men aged 30-50 years with diagnosis of myocardial infarction. Patients were divided into 2 groups according to age: group 1 - 11 patients aged 30-39 years, group 2 - 21 patients aged of 40-50 years. Levels of sex hormones were measured by IFA. Level of fibrinogen, prothrombin index, plasma recalcification time, fibrinolytic activity, indices of aggregation and disaggregation were also determined. RESULTS: Testosterone level in the group I was more decreased in comparison with the Group 2 and level of fibrinogen was higher in the group 1 (3.9+/-0,7) in comparison with the group II (3.1+/-0.8; p<0.05). Pearsons correlation between estradiol and fibrinogen in the group 1 was 0.613 (p<0.05). No such relationship was found in the group 2. Pearsons correlation between testosterone and prothrombin index was 0,477 (p<0.009). CONCLUSION: Endogenous testosterone level is one of the factors which influence haemostatic system, but this effect is not well-defined and requires further study.

[Various neurohumoral aspects of hemodynamic changes in patients with hypertension after correction of electrolyte disorders]. / Nekotorye neirogumoral'nye aspekty gemodinamicheskikh sdvigov u bol'nykh gipertonicheskoi bolezn'iu pri korrektsii élektro- litnykh narushenii.

Changes in activity of sympathetic-adrenal and + renin-angiotensin-aldosterone systems (SAS and RAAS), hemodynamics and electrolyte metabolism when correcting sodium balance in consideration of their "salt sensitivity" were studied in 83 hypertension stage I and II patients. In moderate restriction of sodium chloride response of the patients was not uniform. "Salt--sensitive" subjects responded positively with improvement of central and peripheral hemodynamics, electrolyte balance in enhanced activity of SAS and RAAS. In salt nonresponders and in paradoxical sensitivity SAS and RAAS show activation, most distinct in paradoxical sensitivity, and worse central and peripheral hemodynamics, electrolyte imbalance.

[Changes in vascular reactivity during the noradrenaline test in patients with hypertension]. / Izmeneniia sosudistoi reaktivnosti pri provedenii proby s noradrenalinom u bol'nykh gipertonicheskoi bolezn'iu.

To study vascular responses and to choose a differential therapy, 51 patients with hypertensive disease underwent a pressor test combined with intravenous epinephrine. The test revealed two types of blood pressure control. In type I responses (normotensive responses), there was a good antihypertensive effect shown by beta-adrenoblockers and/or a course of physical trainings. In type II (hypertensive responses), alpha-adrenoblockers and diuretics proved to be more effective. A relationship was found between the type of responses and the activity of the renin-aldosterone system.

[Changes in the functional activity of the sympathetico-adrenal system after correction of electrolyte metabolism in patients with hypertension]. / Izmenenie funktsiona'lnoi aktivnosti simpatiko-adrenalovoi sistemy pri korrektsii élektrolitnogo obmena u bo'lnykh gipertonicheskoi bolez'niu.

Parameters of the sympathoadrenal system were studied in 81 patients with I-II stages essential hypertension. Their changes were analysed depending on the disease stage; study also included the interrelation between electrolyte metabolism, and sympathoadrenal and renin-aldosterone systems. Moderate consumption of common salt in "salt-sensitive" patients caused a significant decrease in the activity of the sympathoadrenal system, while in "salt nonsensitive", patients with paradoxical reaction this correction of salt regimen of nutrition activated the sympathoadrenal system. Thus, use of this non-pharmacological method of treatment with limitation of common salt in essential hypertension patients requires a differential approach, depending on "salt sensitivity".

[Clinical effectiveness and a change in the tolerance for physical loading in hypertension patients with a moderate limitation of table salt consumption]. / Klinicheskaia éffektivnost' i izmenenie tolerantnosti k fizicheskim nagruzkam u bol'nykh gipertonicheskoi bolezn'iu pri umerennom ogranichenii potrebleniia povarennoi soli.

Salt sensitivity was measured in 38 patients with first- and second-stage essential hypertension. Patients with high salt sensitivity were identified, in whom moderately limited (to 6 or 5 g daily) dietary salt consumption produced a hypotensive effect. A combination of low-sodium diet and hypotensive drugs in salt-sensitive patients allows diminished dosage of medication. Moderately-limited dietary salt uptake was shown to increase exercise tolerance in patients with essential hypertension.

[Changes in the hemodynamics and cardiac function of hypertension patients on moderate limited consumption of table salt]. / Izmenenie gemodinamiki i funktsional'nogo sostoianiia serdtsa pri umerennom ogranichenii potrebleniia povarennoi soli u bol'nykh gipertonicheskoi bolezn'iu.

A total of 50 patients with essential hypertension, I-II stages, were investigated to study changes in peripheral and intracardiac hemodynamics and myocardial contractility in moderate restriction of sodium chloride in "salt-sensitive" patients (SSP). In such patients (84% of all examinees) with mild arterial hypertension moderate restriction of SC consumption causes a sufficient antihypertensive effect determined by considerable improvement of peripheral hemodynamic indices and improvement of myocardial pump function and contractility, and in patients with moderate and severe hypertension it potentiates an antihypertensive effect and influence of drug therapy on hemodynamics. In non-SSP moderate restriction in SC consumption was ineffective. A sufficient antihypertensive effect in them resulted from the use of drug therapy at higher dosage than in SSP.