[Surgical policy in treatment of patients with infected aortofemoral bifurcation allografts]. / Taktika khirurgicheskogo lecheniia bol'nykh s infektsiei aorto-bedrennykh bifurkatsionnykh alloprotezov.

Described in the article are the results of treating a total of 44 patients who endured repeat operations for infection of aortofemoral bifurcation allografts over the period between 2001 and 2018. These patients had previously undergone reconstructive operations using various synthetic grafts for lower limb ischaemia on the background of lower-limb artery atherosclerosis and infrarenal aortic aneurysms. Infection of synthetic vascular allografts in these patients was observed both in the immediate and remote postoperative periods. The dominating infection in 70% of patients was methicillin-resistant Staphylococcus aureus. The main objective risk factors for infection of bifurcation grafts were found to be as follows: stage III-IV chronic lower limb ischaemia (according to the Fontaine-Pokrovsky classification), diabetes mellitus, and prior operations on lower-limb arteries. Two of the 44 patients were operated on for reinfection after repeat aortofemoral bypass grafting. 30% of patients underwent repeat surgery with symptoms of sepsis. After meticulous additional examination and preoperative preparation the patients were subjected to secondary simultaneous operation, i.e., removal of the synthetic aortofemoral bifurcation prosthesis and aortofemoral bifurcation autovenous repeat reconstruction (repeat bypass grafting) in situ. Aortofemoral bifurcation grafts were formed using superficial femoral veins from both legs. Four patients died in the immediate postoperative period. Other short-term complications included arrosive bleeding with or without sepsis, amputation of one leg due to graft limb thrombosis, and development of peritonitis resulting from perforation of the jejunum. In the remote period, patency of autovenous grafts was confirmed in 37 patients. Of long-term complications, mention should be made of the following: formation of aneurysms of distal anastomoses and thrombosis of one of the limbs of the autovenous graft. The patients were successfully operated on now using synthetic grafts in infection-free conditions. Hence, a method of surgical decision-making in patients with infected aortofemoral bifurcation grafts is the use of the technique of complete removal of the infected synthetic graft with simultaneous in situ replacement using autovenous grafts from superficial femoral veins, active pre- and postoperative antibiotic therapy. Such policy made it possible to decrease the mortality rate to 9%, with a limb-salvage rate of 97.5% and long-term graft patency rate amounting to 92.5%.

[Clinical study of efficacy and safety of Aducil in patients with chronic lower limb ischaemia]. / Klinicheskoe issledovanie éffektivnosti i bezopasnosti Adutsila pri khronicheskoi ishemii nizhnikh konechnostei.

AIM: The study was aimed at assessing efficacy and safety of treatment with Aducil® (cilostazol) compared with Trental® 400 in patients with moderate-to-severe intermittent claudication due to peripheral atherosclerosis. PATIENTS AND METHODS: The study included a total of one hundred and forty-five 36-to-75-year-old patients. The participants were distributed into 2 groups according to the inclusion/exclusion criteria in a 2 to 1 proportion: patients in group 1 received Aducil® 100 mg BID, in group 2 - Trental® 400 TID for 12 weeks. 142 subjects completed the protocol. RESULTS: Analysis of the effectiveness of treatment according to the primary criterion showed a better effectiveness of Aducil® as compared with Trental® 400. Subjects who received Aducil® had a higher increase in the absolute maximum walking distance after 12 weeks of treatment as compared with those taking Trental® 400: 126±110 m versus 45±39 m, respectively (р<0.001). Subjects who received Aducil® had a statistically significant improvement in quality of life parameters such as physical and mental health components according to the SF-36 questionnaire after 12 weeks of treatment (р≤0.01). Subjects in Aducil® group had better quality of life with an increase from 34 to 40 points according to the physical component score, while patients in Trental® 400 group demonstrated minor positive changes (from 35 to 37 points); mean mental component score increased from 45 to 48 points in Aducil® group as compared with an increase from 45 to 47 points in Trental® 400 group. While self-reported physical health status was similar between the groups at baseline, subjects in Aducil® group reported better physical functioning after treatment (р=0.016). Two adverse events were registered in two subjects in Aducil® group. CONCLUSION: Analysis of the study endpoints demonstrated that Aducil® had better treatment effectiveness in patients with chronic lower limb ischemia stage IIB according to the classification of A.V. Pokrovsky-Fontaine as compared with Trental® 400, while the safety profile and drug tolerance were similar between the two.

[Surgical treatment of a patient presenting with an infected aortofemoral bifurcation prosthesis]. / Khirurgicheskoe lechenie bol'nogo s infitsirovannym aorto-bedrennym bifurkatsionnym protezom.

Described herein is a clinical case report regarding successive treatment of a patient presenting with total infection of an aortofemoral bifurcation vascular prosthesis and a purulent fistula in the left iliac-inguinal region. The patient was subjected to removal of the infected aortofemoral bifurcation prosthesis, followed by autovenous aortofemoral bifurcation prosthetic repair. There were no pyo-haemorrhagic complications in the postoperative period. The wounds of the femurs and in the inguinal regions healed with second intention. Check-up computed tomography performed 3 months postoperatively demonstrated satisfactory patency of the autovenous graft and no retroperitoneal formations.

[Radiofrequency ablation in comprehensive surgical treatment of patients with varicose veins of lower limbs]. / Radiochastotnaia obliteratsiia v kompleksnom khirurgicheskom lechenii bol'nykh s varikoznoi bolezn'iu nizhnikh konechnostei.

Analysed herein are the results of using radiofrequency ablation (RFA) in comprehensive surgical treatment of patients presenting with varicose veins of the lower extremities. The study included a series of ninety-eight 28-to-60-year-old patients (with a total of 105 operations performed) suffering from varicose veins of the lower limbs. Of these, there were 10 men (10.3%) and 88 women (89.7%). Venous disease of clinical class C2 according to the CEAP classification was diagnosed in 80 patients, that of class C3 in 17, and that of class C4a in 1 patient. The procedure of RFA was performed by means of the VNUS device model RF62. The impact was exerted in an automatic mode, maintaining the catheter's temperature at 120° C during a 20-second treatment cycle for each 7 cm of the vein's length. In all cases, each 7-cm-long venous segment to be treated was acted upon 4 times. Forty-five patients after RFA underwent ultrasonographic monitoring performed first on POD 7 and then at 3, 6, 12 and 24 months. Recanalization of the trunk of the great saphenous vein (GSV) was registered in 3 (2.8%) cases at terms up to 3 months after the operation. In 2 cases recanalization turned out to be provoked by an incompetent perforant vein in the lower third of the femur. Seven (6.6%) patients with a large diameter of the great saphenous vein were found to develop post-closure hyperpigmentation which resolved spontaneously 8 months later. The remaining patients, with strict adherence to the indications for RFA, demonstrated complete obliteration of the vessel treated, with no recanalization observed ultrasonographically 10-12 months after the procedure. An additional experimental study with a morphological analysis confirmed appropriateness of carrying out four 20-second treatment cycles of RFA in each segment of the vein. A conclusion was made that RFA used in comprehensive surgical treatment for varicose veins of the lower limbs makes it possible to attain good therapeutic and cosmetic results that persist over time, if conducted in compliance with the mentioned fundamentally essential peculiarities of performing the procedure.

[Analysis of the clinical application of epidermal growth factor ("Heberprot-P") and bioplastic material ("Collost") in treatment of skin and soft tissues defects in patients with diabetic foot syndrome].

RELEVANCE: Currently, there is increasing the number of diabetic foot patients with tissues defects. The local treatment of this pathology against the backdrop of diabetic angiopathy and polyneuropathy is a topical issue. AIM: Treatment of wound defects in patients with neuroischemic form of diabetic foot syndrome; study of the effectiveness of collagen implants and gene-therapy technologies in wound closure. MATERIAL AND METHODS: The comparative study was conducted for analyzing clinical effects of "Heberprot-P" and bioplastic material "Collost" on wound healing process in patients with verified diagnosis "diabetic foot syndrome" on the base of City Clinical Hospital №81(Moscow) and "Diabetic Foot" center (Kazan). RESULTS: The article shows the availability, methodology, results of combination treatment of wound defects of lower limbs in DFS patients with gen-therapy methods and bioplastic materials based on native type I collagen. CONCLUSION: The use of bioplastic materials based on native type I collagen for treatment of tissue defects in patients with diabetic foot is preferably than the use of epidermal growth factor.

[Outcomes of reconstructive operations in gerontological patients with diabetic foot syndrome].

The authors share herein their experience in treating a total of two hundred and forty-six patients presenting with an ischaemic form of diabetic foot syndrome on the background of secondary to occlusion ofmajor arteries. The patients'average age amounted to 74 years. According to the findings of ultrasonographic angioscanning and radiopaque aorto- arteriography, 62.3 % of the patients were diagnosed as having bilateral lesions of the arterial bed and only 37.7 % of the patients had lesions of the major vessels on one side. Reconstructive operations on the aortoiliac-femoral zone were performed in sixty-nine (28 %) patients, distal reconstruction in one hundred and twenty-seven (52 %) patients, multi-storey reconstructions in eighteen (7 %), and prolundoplasty in thirty-two (13 %) patients. Direct revascularization of lower extremities made it possible to save the supporting foot in 89 % of the patients undergoing proximal reconstructions and in 83 % of the patients subjected to distal reconstructions, as well as to decrease the rate of high amputations to 11 %.

[Distal reconstructions under critical lower limb ischemia in elderly patients].

Performong reconstructive operations on arteriae is the only way to avoid limb amputation in patients with critical limb ischemia. Whereas reconstructive manipulations on distal arteriae, especially in patients older then 75 years, are often entailed by thrombotic complications. High peripheric vessel resistance is considered to be the crucial factor of the bypass thrombosis. The conducted study demonstrated the efficacy of the use of vena saphena magna collateral tributaries as bypass unload collectors. Femoral distal autovenous in situ reconstruction decreases vessel resistance. Due to the arterial reconstruction with bypass unload using unligated autovenous tributaries the cumulative bypass patency was 75,1% a year after the procedure. 5-year cumulative bypass patency was 53,8%. 5 - year lethality was 28,6%.

[Autovenous bypass in situ in distal occlusions of the arteries]. / Autovenoznoe shuntirovanie in situ pri distal'nykh okkliuziiakh arterii.

In patients with bad distal bed and blood flow along the bypass two functioning venous collaterals were left with the diameter less than 1 mm, with the blood flow volume 100-150 ml/min one collateral was left, if the volume was 150-200 ml/min it was not necessary to make an arterio-venous output. One-two functioning collaterals left did not influence the volume and linear velocity of blood flow along the bypass and the parameters of hemodynamics. 78 patients (91%) were discharged with the functioning bypasses and decreased ischemia. A year later thrombosis of the bypass was noted in 6 (14%) of 43 follow-up patients, stepwise liquidation of one or two collaterals was fulfilled in 5 patients due to a more than 1 mm dilatation. Prognostically the blood flow in the zone of a distal anastomosis less than 100 ml/min is thought to be most critical.

[Treatment of pyonecrotic complications in diabetic macroangiopathy]. / Lechenie gnoino-nekroticheskikh oslozhnenii pri diabeticheskoi makroangiopatii.

Results of treatment of 104 patients aged from 47 to 82 years with stage IV talocrural ischemia (by A.V. Pokrovsky) due to diabetic macroangiopathy were analyzed. Significant depression of immune status was revealed: number of T- and B-lymphocytes decreased by 40-50%, phagocytosis--by 65-75%, number of immunoglobulins--by 25-30%. The majority of the patients had endotoxicosis, hypercoagulation and hyperlipidemia; the correction of it by hemosorption and plasmapheresis was performed depending on the disease stage. 90 patients underwent surgery. Reconstruction in aorto-ileo-femoral zone was performed in 57 patients (in 34--with good results), in femoro-popliteo-femoral zone--in 33 patients (in 19--with good results). The "Gore-Tex" grafts were the plastic material for reconstruction, but autovein in situ was also used in femoro-popliteal zone.

[Surgical treatment of middle-aged and elderly patients with chronic ischemia and distal occlusions]. / Khirurgicheskoe lechenie bol'nykh pozhilogo i starcheskogo vozrasta s khronicheskoi ishemiei pri distal'nykh okkliuziiakh.

Operative treatment for critical ischemia was performed on 346 elderly and senile patients. An assessment of the distal bed and outflow pathways has shown the conditions for the reconstruction of the vessels to be unfavorable in 257 (74%) patients. Femoro-proximal-popliteal shunts were made in 82 patients with good effect in 74 of them. Femoro-distal-popliteal and tibial shunts were made in 62 patients with good effect in 52. In 12 patients out of 20 with the isolated plasty of the profound femoral artery better blood flow and arrest of pains in rest were noted. Lumbar sympathectomy was performed in 142 (41%) patients, in 46 of them it was combined with continuous intraarterial infusion and in 20 patients--in combination with the rotor osteotrepanation on the femur and shin. Good results after sympathectomy were noted in 102 patients.