[Features of biochemical changes in blood serum according to the form of progression of idiopathic and dysplastic coxarthrosis].

Carried out biochemical studies of blood serum (collagenase activity, glycosamineglicans and hydroxyproline fractions) of 72 patients with hip idiopathic osteoarthrosis and 30 patients with dysplastic osteoarthrosis of the iv-th stage in.accordance with J. H. Kellgren and J. S. Lavrence depending on the form of pathologic process progression. It has been proved that both with idiopathic and dysplastic coxartrosis metabolism of basic protein of osteochonrous tissue was broken both in catabolic and in synthetic phase of this process. The most deep changes 1 of biochemical values (collagenase, free and proteinbinded hydroxyprolines, the content of glycosamines) have been observed with rapid form of course progression of idiopathic and dysplastic coxarthrosis. Definite appropriateness promotesin.patients better understanding of coxarthrosis pathogenese, development of diagnostic and medical measures for patients with this severe orthopedic pathology.

[Mechanism of early metabolism disorders and immunological reactivity in children with Perthes disease]. / O mekhanizme rannikh narushenii obmena i immunologicheskoi reaktivnosti u detei s bolezn'iu Pertesa.

Submitted in the paper are data to the effect that parameters of certain biochemical indices for blood plasma and cell link of the immune system could allow some judgement about the character of the pathological process in children with Perthes disease. Autoimmune inflammation caused by foci of chronic infection in the organism aggravates the course of aseptic necrosis in the proximal portion of the thighbone or else is a trigger mechanism of its development.

[Cefzol level in the blood and tissues after its intramuscular and intravenous administration in patients with post-traumatic osteomyelitis]. / Soderzhanie kefzola v krovi i tkaniakh pri vnutrimyshechnom i vnutrivennom vvedeniiakh bol'nym posttravmaticheskim osteomielitom.

The authors present the results of their studies of the concentrations of kephsol in the bones, in the soft tissues and in the plasma (48 samples) of the patients with posttraumatic osteomyelitis in intramuscular and intravenous administration of the drug. It is pointed out that the administration of kephsol in the ways mentioned above may lead to the achievement of an effective concentration of the drug in the pathology focus area only for some types of staphylocci.