Assuntos
COVID-19/epidemiologia , Nível de Saúde , Hepatopatias/epidemiologia , Pandemias , Síndrome de Alagille/epidemiologia , Atresia Biliar/epidemiologia , COVID-19/diagnóstico , Criança , Doença Crônica , Suscetibilidade a Doenças , Displasia Ectodérmica/complicações , Feminino , Hepatite B Crônica/epidemiologia , Degeneração Hepatolenticular/epidemiologia , Humanos , Itália/epidemiologia , Deformidades Congênitas dos Membros/complicações , Cirrose Hepática/epidemiologia , Hepatopatias/etiologia , Masculino , Dermatoses do Couro Cabeludo/complicações , Dermatoses do Couro Cabeludo/congênito , Situs Inversus/complicaçõesRESUMO
OBJECTIVE: The objective of this study was to evaluate possible influences of parenteral nutrition on growth and bone development in preterms and to search for markers of bone status. STUDY DESIGN: Metacarpus bone transmission time (mc-BTT) was performed at birth, 21 days and 36 weeks of gestational age (GA) in preterms, receiving two different nutritional regimens, together with biochemical analysis. RESULT: A total of 234 patients were studied. Newborns with aggressive nutrition had significantly better growth rate and higher values of mc-BTT until discharge. Mc-BTT at day 21 correlates positively with nutritional intakes and phosphatemia; lower limb length positively correlated with mc-BTT (P<0.01). Newborns with low energy intake in the first week of life (<70 kcal kg(-1) per day) and low serum phosphate level (<1.4 mmol l(-1)) at 21 days had lower mc-BTT at 36 weeks of GA (P<0.01). CONCLUSION: Aggressive parenteral intakes in preterms improve growth and bone status in the short-medium term, suggesting that early nutrition could influence bone development.
Assuntos
Biomarcadores/sangue , Densidade Óssea , Desenvolvimento Ósseo/fisiologia , Doenças Ósseas , Doenças do Prematuro , Nutrição Parenteral/métodos , Fosfatos/sangue , Absorciometria de Fóton/métodos , Doenças Ósseas/sangue , Doenças Ósseas/diagnóstico , Doenças Ósseas/prevenção & controle , Intervenção Médica Precoce/métodos , Ingestão de Energia , Feminino , Humanos , Fenômenos Fisiológicos da Nutrição do Lactente , Recém-Nascido , Recém-Nascido Prematuro/crescimento & desenvolvimento , Doenças do Prematuro/sangue , Doenças do Prematuro/diagnóstico , Doenças do Prematuro/prevenção & controle , Itália , Masculino , Ossos Metacarpais/metabolismo , Ossos Metacarpais/patologiaAssuntos
Nutrição Parenteral/métodos , Nutrição Parenteral/normas , Adolescente , Glicemia/metabolismo , Cálcio/sangue , Criança , Pré-Escolar , Humanos , Lactente , Magnésio/sangue , Pediatria/normas , Fosfatos/sangue , Potássio/sangue , Estudos Retrospectivos , Sódio/sangue , Triglicerídeos/sangueRESUMO
OBJECTIVE: To study the possible influences of amino acid (AA) intakes on growth and bone status in preterms. STUDY DESIGN: Newborns, weighing <1250 g, received standard (S) or higher (H) parenteral AA intakes (3 or 4 g kg(-1) per day). Anthropometry, biochemistry and quantitative ultrasound (metacarpus bone transmission time (mcBTT), in µs) were measured prospectively. RESULT: A total of 55 patients in group S and 60 in group H were studied. Significantly better growth rate was found in the H group during the study without signs of intolerance. We found a significant decrease in mcBTT from birth to 21 days in the H group; nonetheless, mcBTT at 36 weeks of gestational age significantly positively correlated with early AA and energy intakes. A significant positive correlation between mcBTT and lower limb length (LLL) at 21 days was found. CONCLUSION: Early higher AA intakes improved growth without short-term AA intolerance. Nutritional parameters could influence bone growth. LLL was the anthropometric parameter that best correlated to bone status.