Time-Frequency Analysis of Cardiovascular and Cardiorespiratory Interactions During Orthostatic Stress by Extended Partial Directed Coherence.

In this study, the linear method of extended partial directed coherence (ePDC) was applied to establish the temporal dynamic behavior of cardiovascular and cardiorespiratory interactions during orthostatic stress at a 70° head-up tilt (HUT) test on young age-matched healthy subjects and patients with orthostatic intolerance (OI), both male and female. Twenty 5-min windows were used to analyze the minute-wise progression of interactions from 5 min in a supine position (baseline, BL) until 18 min of the orthostatic phase (OP) without including pre-syncopal phases. Gender differences in controls were present in cardiorespiratory interactions during OP without compromised autonomic regulation. However in patients, analysis by ePDC revealed considerable dynamic alterations within cardiovascular and cardiorespiratory interactions over the temporal course during the HUT test. Considering the young female patients with OI, the information flow from heart rate to systolic blood pressure (mechanical modulation) was already increased before the tilt-up, the information flow from systolic blood pressure to heart rate (neural baroreflex) increased during OP, while the information flow from respiration to heart rate (respiratory sinus arrhythmia) decreased during the complete HUT test. Findings revealed impaired cardiovascular interactions in patients with orthostatic intolerance and confirmed the usefulness of ePDC for causality analysis.

Effect of considering constant variance time-frequency autoregressive models for HRV analysis.

Time-varying autoregressive modeling may consider the driving noise variance as a constant. In this work, the properties of the autoregressive driving noise variance of heart rate variability, with different stationary physiological conditions (resting in supine and sitting; exercise) are obtained. The effect of constant variance consideration for ramp exercise and recovery (a nonstationary condition) is also evaluated by the comparison of the time-varying absolute spectral parameters obtained by parametric estimation, allowing or not the modeling of time-varying noise variance, and a non-parametric time-frequency analysis. The driving noise variance presented a direct non-linear relationship with the heart period for the stationary maneuvers (r=0.91), while for the nonstationary condition, the use of a constant driving noise resulted in bias for the estimation of heart rate variability spectral parameters. A time-varying driving noise variance should be considered.