Use of natural antioxidants for the correction of changes in general and local parameters of lipid peroxidation and antioxidant defense system during experimental eye burn.

The effect of natural antioxidants in grade III chemical eye burn was studied in experiments on rabbits at various stages of burn disease. The use of histochrome, Gingko Biloba, and diquertin in combination with complex drug therapy decelerated the decrease in the antioxidant potential of tear fluid and blood plasma. This treatment was also followed by a decrease in the concentration of end products of free radical oxidation.

Antioxidant potential of tear fluid and blood plasma in rabbits with grade III chemical eye burn at various stages of burn disease.

The antioxidant potential of tear fluid and plasma in rabbits with chemical eye burn of grade III was measured at various stages of burn disease. Eye burns were accompanied by depletion of the antioxidant system in tear fluid and plasma and impairment of antioxidant defense in the whole organism. These changes contribute to activation of free radical lipid peroxidation. The pathological changes in the organism and eye were most pronounced at the stage of trophic disturbances.

Effect of natural antioxidants on antioxidant activity and lipid peroxidation in eye tissue of rabbits with chemical burns.

Chemical eye burns were accompanied by free radical oxidation of lipids and dysfunction of the antioxidant protection system. The decrease in antioxidant activity of blood plasma reflected a generalized type of these processes. The concentration of thiobarbituric acid-reactive substances increased in blood plasma from rabbits with eye burns. The severity of disturbances was maximum at the stage of trophic disorders. Combination therapy with antioxidants and standard pharmaceuticals effectively inhibited lipid peroxidation in eye tissue of experimental animals.

[Specific features of the pathogenesis of epichlorohydrin eye burns and their treatment (an experimental clinico-morphological study)]. / Osobennosti patogeneza ozhogov glaz épikhlorgidrinom i ikh lechenie (éksperimental'noe kliniko-morfologicheskoe issledovanie).

Specific features in the pathogenesis of ocular burns with a solution of an organic product, epichlorohydrin, are analyzed. Abnormalities in the vascular system anterior portion were revealed, related to the toxic effect of the agent on tissue vessels and to enhanced permeability and involvement of not only the cornea, but (and even more so) of the iris, where necrotic changes and hemorrhages eventuating in iris atrophy were detectable. Contrykal (hordox) therapy promoted a drastic inhibition of leukocytic and lymphocytic migration into burnt tissue, this resulting in a month in the formation of gentle cicatricial tissue with negligible residual inflammatory infiltration in the burn wound. Iris changes still persisted, since the drug appeared to have no effect on this process.

[The clinico-morphological validation of the pathogenetic treatment of industrial eye burns]. / Kliniko-morfologicheskoe obosnovanie patogeneticheskogo lecheniia promyshlennykh ozhogov glaz.

The paper generalizes and analyses experimental results obtained in 60 eyes of 30 rabbits after induced burn by means of epichlorhydrine that is widely used in chemical industry and produces industrial burns of the eye in 20% of all burns in the town of Sumgait. Clinico-morphologic researches allowed to reveal peculiarities of pathogenesis of severe eye burns produced by epichlorhydrine causing toxic lesions of the iris and to substantiate effectiveness of hordox used in such cases, that has not only antiproteolytic, but also antiinflammatory, cytotoxic action on the burn process.