RESUMO
Treatment of chronic hepatitis C is still unspecific. However, there is great expectancy concerning the new pegylated interferons. As there has been much controversy about the best parameters to determine whether treatment is effective, we analyzed several criteria currently used for evaluation, including serum alanine aminotransferase (ALT) normalization, viral load reduction and improvement of hepatic histology.
Assuntos
Avaliação de Medicamentos/métodos , Avaliação de Medicamentos/normas , Hepatite C Crônica/sangue , Hepatite C Crônica/tratamento farmacológico , Alanina Transaminase/sangue , Antivirais/uso terapêutico , Hepacivirus/genética , Hepacivirus/isolamento & purificação , Hepatite C Crônica/virologia , Humanos , Interferons/uso terapêutico , Fígado/patologia , Fígado/virologia , Carga ViralRESUMO
Treatment of chronic hepatitis C is still unspecific. However, there is great expectancy concerning the new pegylated interferons. As there has been much controversy about the best parameters to determine whether treatment is effective, we analyzed several criteria currently used for evaluation, including serum alanine aminotransferase (ALT) normalization, viral load reduction and improvement of hepatic histology.
