Assessment of validity and predictability of the FiO2-SpO2 transfer-function in preterm infants.

In this paper an investigation of the gain, delay, and time-constant parameters of the transfer function describing the relation between fraction of inspired oxygen (FiO2) and oxygen saturation in the blood (SpO2) in preterm infants is presented. The parameters were estimated following FiO2 adjustments and goodness of fit was used to assess the validity of the model when using an assumed first-order transfer function. For responses identified to be first-order, the estimated parameters were then clustered to identify areas where they tended to be concentrated. Each group described an operating region of the transfer function; thus, predicting the right operating region could potentially assist a range-based robust inspired oxygen controller to provide more optimal control by adapting itself to different clusters. Accordingly, the samples were assigned labels based on their cluster associations and 14 features available at the time of each adjustment were used as inputs to an artificial neural network to classify the clustered samples. The validity study suggested that 37% of the adjustments were followed by first-order responses. Prediction studies on the first-order responses indicated that the clusters could be predicted with an average accuracy of 64% when the parameters were divided into two groups.

Investigation of catheter curvature and genetic algorithms in conductance catheter optimization.

Catheter curvature affects accuracy of intra-ventricular blood volume measurement when using conductance catheter techniques, especially with irregular geometries, such as in the right ventricle. To investigate this effect, we present results from using different curved catheter configurations and different numbers of electrodes in a simple Finite Element model. It was found that there is an apparent increase in accuracy with curvature, due to greater linearity in the field in the region of the measurement electrodes, which are located farther from the source electrodes as curvature increases. Also, optimization using Genetic Algorithms is presented as a method to find the optimal distribution of measurement electrodes. We plan to extend these results to develop improved electrode configurations for using in blood volume measurement in the right ventricle.

Short-term effects of severe dietary carbohydrate-restriction advice in Type 2 diabetes--a randomized controlled trial.

OBJECTIVE: This study sought to examine the effects of a 3-month programme of dietary advice to restrict carbohydrate intake compared with reduced-portion, low-fat advice in obese subjects with poorly controlled Type 2 diabetes. RESEARCH DESIGN AND METHODS: One hundred and two patients with Type 2 diabetes were recruited across three centres and randomly allocated to receive group education and individual dietary advice. Weight, glycaemic control, lipids and blood pressure were assessed at baseline and 3 months. Dietary quality was assessed at the end of study. RESULTS: Weight loss was greater in the low-carbohydrate (LC) group (-3.55 +/- 0.63, mean +/- sem) vs. -0.92 +/- 0.40 kg, P = 0.001) and cholesterol : high-density lipoprotein (HDL) ratio improved (-0.48 +/- 0.11 vs. -0.10 +/- 0.10, P = 0.01). However, relative saturated fat intake was greater (13.9 +/- 0.71 vs. 11.0 +/- 0.47% of dietary intake, P < 0.001), although absolute intakes were moderate. CONCLUSIONS: Carbohydrate restriction was an effective method of achieving short-term weight loss compared with standard advice, but this was at the expense of an increase in relative saturated fat intake.

The effect of fiber orientation on volume measurement using conductance catheter techniques.

Estimation of parallel conductance using the impedance electrode technique is usually done assuming isotropic conditions. This may not be the best solution since the myocardium is an anisotropic material. This paper exposes the effect of fiber orientation for volume measurement using a conductor model with asymmetrical source electrodes. Simulation results show calculated volumes between surrounding materials with and without myocardial fiber orientation included in the model. We plan to extend these study results to the real heart for developing conductance catheter techniques for use in blood volume measurements in the right ventricle.

A technique for the assessment of sailboard harness line force.

Even though sailboarding is a popular sport with many thousands of participants worldwide the forces experienced whilst sailboarding on water have not been documented. Harness line force is one of the key forces acting when sailboarding. The aim of this paper is to outline a method for measuring this force and to document its magnitude when sailboarding in a range of wind strengths (12 knots to 30 knots) using two different sail sizes (6.5 m2 in lighter winds and 5.0 m2 in stronger ones). A sailboard harness spreader bar was instrumented with a force transducer, amplifier and datalogger, to enable measurement of harness line force while sailboarding. Using this instrumented spreader bar an expert sailboarder sailed in a figure of eight fashion around two buoys lying across the wind. Average harness force measured during each leg of the figure of eight course was 381.6 +/- 43.2 N when using the 5 m2 sail and 415.0 +/- 66.7 N when using the 6.5 m2 sail. The average gybing time was 9.9 +/- 2.0 seconds when using the 5 m2 sail and significantly higher (p = 0.035) 12.2 +/- 1.3 seconds when using the 6.5 m2 sail. The results from this paper indicate that downsizing sail area to cope with the increased wind strength maintains harness force within a manageable range. For the subject in question the average harness line force was approximately 4.9 N/kg body weight.

Performance of sealants applied to first permanent molars in a dental school setting.

PURPOSE: The purpose of this study was to assess the performance of sealants placed by senior dental students as part of a comprehensive dental care program that included periodic patient recall. METHODS: The dental records of 100 patients ranging in age from 6 to 13 years were selected for review to determine the treatments provided for first permanent molars over time. Criteria for inclusion were: 1) at least five documented recall examinations and 2) all four first permanent molars had to have been treated with an occlusal pit and fissure sealant. The data collected included: 1) the age of the patient at the time of initial sealant placement; 2) the subsequent treatment provided to the first permanent molars, including retreatment with sealant or restoration and the date the services were provided; 3) the last date of follow-up examination in the pediatric dental program. RESULTS: A total of 400 molars were followed for an average of 54 months. Fifty-two percent of all molars received no further treatment after initial placement of sealant. Approximately 35% received retreatment with sealant only. The total number of molars receiving sealant material only was 343 (86%). The total number of teeth that were judged to require restoration was 57 (14%). No relationship was noted between the patient's age at placement of the occlusal sealant and sealant performance. CONCLUSION: In a dental school clinic, occlusal sealants were effective at preventing caries in a comprehensive care program that included periodic recall.