Glomerular filtration rate, cardiovascular risk factors and insulin resistance.

The aim of this paper was to study the estimated glomerular filtration rate (eGFR), its changes with age, and its association with systolic blood pressure (SBP) and diastolic BP (DBP), indicators of obesity, dyslipemia, insulin resistance and inflammation on a random population sample. BP, weight, size and waist circumference (WC) were recorded at home. Fasting morning blood samples were analysed. The eGFR was calculated with MDRD (eGFR-MDRD), Cockroft-Gault (eGFR-CG) adjusted to 1.73 m2 and reciprocal of serum creatinine (100/serum cretinine). A total of 1016 individuals, 722 females (41.97 +/- 0.66 years old) and 294 males (42.06 +/- 0.99 years old), completed the laboratory tests. The mean of 100/Scr was 115.13 +/- 0.60 (dl/mg), the mean eGFR-CG was 98.48 +/- 0.82 ml/min/1.73 m2; the mean eGFR-MDRD was 85.15 +/- 0.58 ml/min/1.73 m2. The eGFR-MDRD decreased with age and with the number of risk factors in both sexes. The eGFR-MDRD < 60 ml/min/1.73 m2 adjusted prevalence was 6.2 per 100 inhabitants (CI 95%, 4.7-7.7), 3.6 (CI 95%, 1.5-5.7) in males and 8.6 (CI 95%, 6.6-10.6) in females. The bivariate analysis showed that the eGFR-MDRD correlates inversely with age, SBP, DBP WC, BMI, serum glucose, serum total cholesterol, LDL cholesterol, serum triglycerides, serum uric acid and, in males, with C-reactive-protein. There was no correlation with either insulinemia or HOMA. The mean eGFR value, its association with cardiovascular risk factors and the prevalence of eGFR < 60 ml/min/1.73 m2 found in a rural population of Argentina are similar to those found in other parts of the world.

Glomerular filtration rate, cardiovascular risk factors and insulin resistance / Filtrado glomerular, riesgo cardiovascular y resistencia a la insulina

The aim of this paper was to study the estimated glomerular filtration rate (eGFR), its changes with age, and its association with systolic blood pressure (SBP) and diastolic BP (DBP), indicators of obesity, dyslipemia, insulin resistance and inflammation on a random population sample. BP, weight, size and waist circumference (WC) were recorded at home. Fasting morning blood samples were analysed. The eGFR was calculated with MDRD (eGFR-MDRD), Cockroft-Gault (eGFR-CG) adjusted to 1.73 m² and reciprocal of serum creatinine (100/serum cretinine). A total of 1016 individuals, 722 females (41.97 ± 0.66 years old) and 294 males (42.06 ± 0.99 years old), completed the laboratory tests. The mean of 100/Scr was 115.13 ± 0.60 (dl/mg), the mean eGFR-CG was 98.48 ± 0.82 ml/min/1.73 m²; the mean eGFR-MDRD was 85.15 ± 0.58 ml/min/1.73 m². The eGFR-MDRD decreased with age and with the number of risk factors in both sexes. The eGFR-MDRD < 60 ml/min/1.73 m² adjusted prevalence was 6.2 per 100 inhabitants (CI 95%, 4.7-7.7), 3.6 (CI 95%, 1.5-5.7) in males and 8.6 (CI 95%, 6.6-10.6) in females. The bivariate analysis showed that the eGFR-MDRD correlates inversely with age, SBP, DBP WC, BMI, serum glucose, serum total cholesterol, LDL cholesterol, serum triglycerides, serum uric acid and, in males, with C-reactive-protein. There was no correlation with either insulinemia or HOMA.The mean eGFR value, its association with cardiovascular risk factors and the prevalence of eGFR < 60 ml/min/1.73 m² found in a rural population of Argentina are similar to those found in other parts of the world.

El objetivo fue evaluar en una muestra poblacional aleatoria el filtrado glomerular estimado (FGe), sus cambios con la edad y su asociación con presión arterial sistólica (PAS) y diastólica (PAD), indicadores de obesidad, dislipemia, resistencia a la insulina e inflamación. En cada domicilio fueron medidos presión arterial, peso y talla y perímetro de la cintura (PC). Se analizaron muestras de sangre en ayunas y fue calculado el FGe usando las fórmulas de MDRD (FGe-MDRD) y Cockroft-Gault (FGe-CG) ajustado a 1.73 m², y la inversa de la creatinina sérica (100/CrS). Completaron el protocolo de laboratorio 1016 sujetos, 722 mujeres (41.97 ± 0.66 años) y 294 varones (42.06 ± 0.99 años). La media de 100/Crs fue 115.13 ± 0.60 (dl/mg), la del FGe-CG 98.48 ± 0.82 ml/min/1.73 m² y la del FGe-MDRD 85.15 ± 0.58 ml/min/1.73 m² (CI 95% 84.00-86.29). El FGe-MDRD disminuyó con la edad y con el número de factores de riesgo cardiovascular en ambos sexos. La prevalecencia ajustada de FGe-MDRD < 60 ml/min/1.73 m² fue 6.2 por 100 habitantes (CI 95%, 4.7-7.7); 3.6 (CI 95%, 1.5-5.7) en varones y 8.6 (CI 95%, 6.6- 10.6) en mujeres. El análisis bivariado mostró correlación inversa del FGe-MDRD con edad, PAS, PAD, PC, IMC, glucemia, colesterolemia total, colesterol-LDL, trigliceridemia, uricemia y, en varones, con la proteina-C-reactiva. No hubo correlación con insulinemia u HOMA. La media del FGe, su asociación con factores de riesgo cardiovascular y la prevalecencia de FGe < 60 ml/min/1.73 m² fueron similares a los hallados en otras partes del mundo.