1.
Mini Rev Med Chem
; 4(4): 361-9, 2004 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15134539
RESUMO
The reaction of NDP kinase was studied in vitro with several antiviral derivatives, using kinetic steady state and presteady state analysis. The enzyme is highly efficient with natural nucleotides but most of the analogs are slow substrates. The catalytic efficiency, also related to the affinity of the analog, is mainly dependent on the presence of a 3'-OH group on the ribose moiety.