1.
J Pharm Sci
; 67(10): 1367-70, 1978 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-702281
RESUMO
The absolute configurations of the enantiomers of N,N,1-trimethyl-cis- and trans-1-phenyl-1,2,3,4-tetrahydro-3-naphthylamines (Ia and Ib) were assigned tentatively from the circular dichroism spectrum of a bridged ketone derived by cyclization of optically active 1-methyl-cis-1-phenyl-1,2,3,4-tetrahydro-3-naphthoic acid (IIa). Thus, (--)-IIa and the corresponding amine, (--)-Ia, were assigned the (2S, 4R)-configuration. Epimerization of (--)-IIa through its methyl ester yielded the trans-acid, (--)-IIb, which established the absolute configuration of (--)-IIb and the corresponding amine, (--)-Ib, as (2R, 4R).
Assuntos
Naftalenos , Tetra-Hidronaftalenos , Dicroísmo Circular , Conformação Molecular , Naftalenos/síntese química , Estereoisomerismo , Tetra-Hidronaftalenos/síntese química
2.
J Pharm Sci
; 61(6): 963-4, 1972 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-5046124
3.
Biochem Pharmacol
; 18(5): 979-91, 1969 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-5789796
4.
J Pharm Sci
; 57(3): 447-51, 1968 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-5655584