RESUMO
A case of preterm premature rupture of membranes (PROM) secondary to first trimester chorial biopsy is described. The newborn survived and physical and psychological development was normal at 1 year of age. On review of the literature, different attitudes may be found with regard to the treatment of PROM: some authors prefer expectant management while others defend extraction of the fetus when reasonable maturity is reached. In both cases the outcome is usually poor for the fetus.
Assuntos
Amostra da Vilosidade Coriônica/efeitos adversos , Ruptura Prematura de Membranas Fetais/etiologia , Recém-Nascido Prematuro/crescimento & desenvolvimento , Adulto , Cesárea , Feminino , Ruptura Prematura de Membranas Fetais/terapia , Maturidade dos Órgãos Fetais , Idade Gestacional , Humanos , Recém-Nascido , Pulmão/embriologia , Masculino , Idade Materna , Gravidez , Gravidez de Alto Risco , Fatores de TempoRESUMO
A prospective and double-blind study was undertaken to compare the effectiveness of two different treatments on two randomized groups of patients with threatened preterm labor. The first treatment consisted of the administration of ritodrine and a placebo; in the second, ritodrine was combined with indomethacin. 22 patients were evaluated in each group. The results obtained for gain in days, number of patients delivered at term, weight of newborns and number of recurrences in each group suggest that treatment with ritodrine and indomethacin is slightly but significantly more effective than treatment with ritodrine and placebo in prolonging pregnancy. No evidence has been found of possible unfavorable vascular effects of indomethacin in the fetus or the newborn.
Assuntos
Indometacina/uso terapêutico , Trabalho de Parto Prematuro/prevenção & controle , Ritodrina/uso terapêutico , Adulto , Ensaios Clínicos como Assunto , Método Duplo-Cego , Quimioterapia Combinada , Feminino , Morte Fetal , Humanos , Mortalidade Infantil , Recém-Nascido , Gravidez , Estudos Prospectivos , Distribuição AleatóriaRESUMO
To study the biogenesis of estrogens by the fetoplacental unit in late pregnancy, dehydroepiandrosterone sulfate was injected directly into the fetus and maternal blood sampled at intervals for 2 hours thereafter. There was no increase of estrone, estradiol, or estriol concentration in the maternal circulation.
