Attitudinal behaviour of agriculturalists towards pesticide use in Pir Panjal Range of Kashmir Himalayas.

BACKGROUND: Attainment of safety during pesticide spraying relies on the farmer's knowledge of pesticide use, attitude and sense of safety. However, such investigations are insufficient in the current study area. METHODS: The study is based on a primary survey of 384 orchardists about the myriad of aspects affecting the use of pesticides and their subsequent effects. RESULTS: The study revealed that knowledge, attitude, and perception had a weighted average index (WAI) and a standard deviation (SD) of 2.85 ± 1.17, 3.55 ± 1.34, and 3.81 ± 0.98 correspondingly. The findings reflect the farmers have a low to moderate level of knowledge, a moderate attitude toward pesticides, and a favourable perception on their utilization. Thus, for farmer personal protective equipment (PPE) use, it scored 2.77 ± 0.90 on the WAI scale, indicating that most farmers use PPEs 'rarely to occasionally' and that none use full protective gear. Furthermore, attitude and PPE usage exhibited a negative relationship with age, as younger people use PPE more than older ones. The findings were consistent for both farming experience and PPE usage. Moreover, there exists a positive association between age with perception and farming experience, knowledge with perception and PPE use, and attitude with perception. CONCLUSIONS: The coefficient of determination (R2) shows that 67.2% of the variability in farmers' PPE use was attributed to factors including knowledge, attitude, perception, and education. A favorable behavioral shift in pesticide usage may be achieved by enhancing farmers' knowledge, attitudes and perceptions, and adequate PPE usage.

Phytochemical and pharmacological review of Cinnamomum verum J. Presl-a versatile spice used in food and nutrition.

Cinnamomum verum is the widely used spice for its medicinal and culinary uses since ages. It is native to Sri Lanka and southern India but also distributed in many Asian, Caribbean, Australian and African countries. It is widely used in food preparations and industrial products like candies, chewing gums, mouthwash and toothpaste. It is also used to treat asthma, bronchitis, diarrhea, headache, inflammation and cardiac disorders. Cinnamaldehyde, eugenol, caryophyllene, cinnamyl acetate and cinnamic acid are the major compounds found in its essential oil. These compounds exhibit a wide range of pharmacological activities including antioxidant, antimicrobial, anti-inflammatory, anticancer, antidiabetic, wound healing, anti-HIV, anti-anxiety and antidepressant, etc. This review highlights its comprehensive and up-to-date information on taxonomy, ethnomedicinal uses, phytochemical composition, pharmacological and toxicity activities. Structure-activity relationship, mechanism of action and some research gaps has also been provided. Owing to its immense medicinal importance, more well-designed in-vivo and clinical studies are required.

Zingerone prevents lead-induced toxicity in liver and kidney tissues by regulating the oxidative damage in Wistar rats.

Among the heavy metal poisonings, lead is considered as a major toxic metal causing hematological, neurological, immunological, hepatic, and renal dysfunctions. Lead causes inhibition of ALAD leading to the ALA accumulation inside the cells. Lead also leads to disruption of the anti-oxidative enzyme system, organ function, and lipid membranes of the cell causing oxidative stress. Zingerone, a phenolic alkanone, is an active edible ingredient present in the ginger that possess varied pharmacological properties. The aim of our study was to evaluate the protective effect of zingerone in lead-induced toxicity in wistar rats. ALAD concentration was improved in kidney and liver tissues treated with zingerone. Protective effect of zingerone was observed in terms of significant improvement in kidney and liver histology, anti-oxidant enzyme activity (CAT, SOD, GPx, and GR), organ function parameters, lipid profile, and decreased level of LPO. Therefore, zingerone pretreatment can be a promising agent for alleviation of lead-induced oxidative damage in cells. PRACTICAL APPLICATIONS: Published reports have revealed that consumption of certain bioactive nutrients for example, flavonoids, mineral elements, and vitamins can offer defense from the environmental lead contamination. Zingerone is a strong anti-oxidant, with very less side effects and has exceptional property of scavenging free radicals, hence reducing the oxidative stresses. This fundamental property of zingerone can alone help in countering the heavy metal toxicity. Different groups have published reported numerous properties of zingerone but as per our understanding till date no study about alleviation of lead toxicity by zingerone in animal model has been undertaken. Hence, we conducted this research to explore the preventive effect of zingerone in lead induced kidney and liver toxicity. The outcome of our study shows potent anti-oxidant effect and ALAD modulatory property of zingerone which makes it suitable edible candidate for use in countering lead toxicity.

Hepatoprotective activity of LC-ESI-MS standardized Iris spuria rhizome extract on its main bioactive constituents.

The study was designed to evaluate the hepatoprotective activity of Iris spuria against paracetamol induced toxicity at two different doses 100 and 200 mg/kg. The extract showed significant protective activity (p>0.01) at both the doses in dose dependent manner. Administration of the plant extract restored the paracetamol induced elevated levels of serum marker and distorted hepatic tissue architecture. The lipid peroxides (LPO) and glutathione (GSH) levels were also restored towards normal in liver tissue significantly. The main chemical constituents of the extract identified by the liquid chromatography-tandem mass spectrometry (LC-ESI-MSMS) were found to be flavones and isoflavonoids. Tectoridin and iristectorigenin A were the principal compounds present in the methanolic extract of Iris spuria.