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1.
JTCVS Open ; 11: 62-71, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36172405

RESUMO

Objective: The utilization of transcatheter aortic valve replacement (TAVR) technology has exceeded that of traditional surgical aortic valve replacement (SAVR). In addition, the role of minimum surgical volume requirements for TAVR centers has recently been disputed. The present work evaluated the association of annual institutional SAVR caseload on outcomes following TAVR. Methods: The 2012-2018 Nationwide Readmissions Database was queried for elective TAVR hospitalizations. The study cohort was split into early (Era 1: 2012-2015) and late (Era 2: 2016-2018) groups. Based on restricted cubic spline modeling of annual hospital SAVR caseload, institutions were dichotomized into low-volume and high-volume centers. Multivariable regressions were used to determine the influence of high-volume status on in-hospital mortality and perioperative complications following TAVR. Results: An estimated 181,740 patients underwent TAVR from 2012 to 2018. Nationwide TAVR volume increased from 5893 in 2012 to 49,983 in 2018. After adjustment for relevant patient and hospital factors, high-volume status did not alter odds of TAVR mortality in Era 1 (adjusted odds ratio, 0.94; P = .52) but was associated decreased likelihood of mortality in Era 2 (adjusted odds ratio, 0.83; P = .047). High-volume status did not influence the risk of perioperative complications during Era 1. However, during Era 2, patients at high-volume centers had significantly lower odds of infectious complications, relative to low-volume hospitals (adjusted odds ratio, 0.78; P = .002). Conclusions: SAVR experience is associated with improved TAVR outcomes in a modern cohort. Our findings suggest the need for continued collaboration between cardiologists and surgeons to maximize patient safety.

2.
Ann Thorac Surg ; 113(3): 783-792, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-33878310

RESUMO

BACKGROUND: Surgical reexploration after cardiac surgery has been associated with increased in-hospital complications and mortality in limited series. The present study examined trends in reoperation and the impact of reoperation on clinical outcomes and resource use in a nationally representative cohort. The study sought to determine patient and hospital factors associated with reexploration and reoperative mortality, defined as failure to rescue surgical (FTR-S). METHODS: Adult hospitalizations entailing cardiac operations (coronary artery bypass or valve) were identified using the 2005 to 2018 National Inpatient Sample. Procedures were tabulated using International Classification of Diseases codes. Hospitals were ranked into tertiles according to risk-adjusted mortality, with the lowest stratified as high performing. Multivariable regression models examined factors associated with reexploration, as well as clinical outcomes, including FTR-S and resource use. RESULTS: Of an estimated 3,490,245 hospitalizations, 78,003 (2.23%) required reexploration with decreasing incidence over time. Valvular procedures, preoperative intraaortic balloon pump use, and liver disease were associated with a greater likelihood of reexploration. Reoperation was associated with increased odds of mortality (adjusted odds ratio [AOR], 3.86; 95% confidence interval [CI], 3.61 to 4.12), perioperative complications, and resource use. Increasing time from index operation to reexploration was associated with higher odds of mortality (AOR,1.10/day; 95% CI, 1.07 to 1.12). High-performing hospitals were associated with lower odds of reexploration (AOR, 0.88; 95% CI, 0.82 to 0.95) and FTR-S (AOR, 0.29; 95% CI, 0.23 to 0.35). CONCLUSIONS: Surgical reexploration after cardiac surgery has declined over time. High-performing hospitals demonstrated lower rates of reexploration and subsequent FTR-S. Although unable to identify specific practices, this study highlights the presence of significant variation in takeback rates, and further study of underlying factors is warranted.


Assuntos
Procedimentos Cirúrgicos Cardíacos , Adulto , Ponte de Artéria Coronária , Mortalidade Hospitalar , Humanos , Incidência , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/cirurgia , Reoperação , Estados Unidos/epidemiologia
3.
Ann Thorac Surg ; 113(4): 1274-1281, 2022 04.
Artigo em Inglês | MEDLINE | ID: mdl-33882292

RESUMO

BACKGROUND: Expedited discharge (within 24 hours) after lung resection has received scrutiny because of concerns for higher readmissions and paradoxically increased costs. The present study examined the impact of expedited discharge on hospitalization costs and unplanned readmissions by using a nationally representative sample. In addition, the study sought to determine interhospital practice variation. METHODS: Adults undergoing elective lobar or sublobar resection were identified using the 2016 to 2018 Nationwide Readmissions Database, and patients with a postoperative duration of hospitalization longer than 5 days or those who experienced any perioperative complication were excluded. Patients were classified as Expedited if their postoperative hospitalization duration was 0 or 1 day and otherwise were classified as Routine. Inverse probability of treatment weighing was used to adjust for intergroup differences. Hospitals were ranked according to risk-adjusted early discharge rates. Multivariable regression models were developed to assess the association of expedited discharge on nonelective 30-day readmissions, as well as associated mortality and costs. RESULTS: Of an estimated 84,152 patients, 13,834 (16.4%) comprised the Expedited group. Compared with the Routine group, the Expedited patients were younger and less likely to have chronic obstructive pulmonary disease and to have undergone open procedures. After adjustment, early discharge was associated with lower incremental costs (ß coefficient: -$3.6K; 95% confidence interval, -4.4 to -2.8), as well as similar readmissions (odds ratio, 0.89; 95% confidence interval, 0.70 to 1.13) and related-mortality. Nearly one-half (48.1%) of all hospitals performed zero early discharges. CONCLUSIONS: Expedited discharge after lung resection is a feasible management strategy and is associated with decreased costs and similar readmission risk compared with the norm. Select individuals should be strongly considered for expedited discharge after lung resection.


Assuntos
Readmissão do Paciente , Procedimentos Cirúrgicos Pulmonares , Adulto , Hospitalização , Humanos , Pulmão , Alta do Paciente , Complicações Pós-Operatórias/epidemiologia , Estudos Retrospectivos , Fatores de Risco
4.
J Intensive Care Med ; 37(4): 535-542, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33783248

RESUMO

PURPOSE: Safety net hospitals (SNH) have been associated with inferior surgical outcomes and increased resource use. Utilization and outcomes for extracorporeal membrane oxygenation (ECMO), a rescue modality for patients with respiratory or cardiac failure, may vary by safety net status. We hypothesized SNH to be associated with inferior outcomes and costs of ECMO in a national cohort. MATERIALS AND METHODS: The 2008-2017 National Inpatient Sample was queried for ECMO hospitalizations and safety net hospitals were identified. Multivariable regression was used to perform risk-adjusted comparisons of mortality, complications and resource utilization at safety net and non-safety net hospitals. RESULTS: Of 36,491 ECMO hospitalizations, 28.2% were at SNH. On adjusted comparison SNH was associated with increased odds of mortality (AOR: 1.23), tracheostomy use (AOR: 1.51), intracranial hemorrhage (AOR: 1.39), as well as infectious complications (AOR: 1.21, all P < .05), with NSNH as reference. SNH was also associated with increased hospitalization duration (ß=+4.5 days) and hospitalization costs (ß=+$32,880, all P < .01). CONCLUSIONS: We have found SNH to be associated with inferior survival, increased complications, and higher costs compared to NSNH. These disparate outcomes warrant further studies examining systemic and hospital-level factors that may impact outcomes and resource use of ECMO at SNH.


Assuntos
Oxigenação por Membrana Extracorpórea , Mortalidade Hospitalar , Hospitais , Humanos , Pacientes Internados , Estudos Retrospectivos , Provedores de Redes de Segurança , Estados Unidos/epidemiologia
5.
Ann Thorac Surg ; 114(2): 426-433, 2022 08.
Artigo em Inglês | MEDLINE | ID: mdl-34437854

RESUMO

BACKGROUND: Despite minimum volume recommendations, the majority of esophagectomies are performed at centers with fewer than 20 annual cases. The present study examined the impact of institutional esophagectomy volume on in-hospital mortality, complications, and resource use after esophageal resection. METHODS: The 2010-2018 Nationwide Readmissions Database was queried to identify all adult patients undergoing esophagectomy for malignancy. Hospitals were categorized as a high-volume hospital (HVH) if performing at least 20 esophagectomies annually and as a low-volume hospital (LVH) if performing fewer than 20 esophagectomies annually. Multivariable models were developed to study the impact of volume on outcomes of interest, which included in-hospital mortality, complications, duration of hospitalization, inflation adjusted costs, readmissions, and nonhome discharge. RESULTS: Of an estimated 23,176 hospitalizations, 45.6% occurred at HVHs. Incidence of esophagectomy increased significantly along with median institutional caseload over the study period, while the proportion on hospitals considered HVHs remained steady at approximately 7.4%. After adjusting for relevant patient and hospital characteristics, HVH status was associated with decreased mortality (AOR, 0.65), length of stay (ß = -1.83), pneumonia (AOR, 0.69), prolonged ventilation (AOR, 0.50), sepsis (AOR, 0.80), and tracheostomy (AOR, 0.66) but increased odds of nonhome discharge (AOR, 1.56; all P < .01), with LVH status as reference. CONCLUSIONS: Many clinical outcomes of esophagectomy are improved with no increment in costs when performed at centers with an annual caseload of at least 20, as recommended by patient advocacy organizations. These findings suggest that centralization of esophageal resections to high-volume centers may be congruent with value-based care models.


Assuntos
Neoplasias Esofágicas , Esofagectomia , Adulto , Procedimentos Cirúrgicos Eletivos , Neoplasias Esofágicas/cirurgia , Mortalidade Hospitalar , Hospitais com Alto Volume de Atendimentos , Hospitais com Baixo Volume de Atendimentos , Humanos , Estudos Retrospectivos
6.
Surgery ; 171(2): 541-548, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-34294450

RESUMO

BACKGROUND: Although patients with opioid use disorder have been shown to be more susceptible to traumatic injury, the impact of opioid use disorder after trauma-related admission remains poorly characterized. The present nationally representative study evaluated the association of opioid use disorder on clinical outcomes after traumatic injury warranting operative intervention. METHODS: The 2010 to 2018 Nationwide Readmissions Database was used to identify adult trauma victims who underwent major operative procedures. Injury severity was quantified using International Classification of Diseases Trauma Mortality Prediction Model. Entropy balancing was used to adjust for intergroup differences. Multivariable regression models were developed to assess the association of opioid use disorder on in-hospital mortality, perioperative complications, resource utilization, and readmissions. RESULTS: Of an estimated 5,089,003 hospitalizations, 54,097 (1.06%) had a diagnosis of opioid use disorder with increasing prevalence during the study period. Compared with others, opioid use disorder had a lower proportion of extremity injuries and falls but greater predicted mortality measured by Trauma Mortality Prediction Model. After adjustment, opioid use disorder was associated with decreased odds of in-hospital mortality (adjusted odds ratio: 0.61; 95% confidence interval, 0.53-0.70) but had greater likelihood of pneumonia, infectious complications, and acute kidney injury. Additionally, opioid use disorder was associated with longer hospitalization duration as well as greater index costs and risk of readmission within 30 days (adjusted odds ratio: 1.36; 95% confidence interval, 1.25-1.49). CONCLUSION: Opioid use disorder in operative trauma has significantly increased in prevalence and is associated with decreased in-hospital index mortality but greater resource utilization and readmission.


Assuntos
Transtornos Relacionados ao Uso de Opioides/complicações , Complicações Pós-Operatórias/epidemiologia , Procedimentos Cirúrgicos Operatórios/efeitos adversos , Ferimentos e Lesões/cirurgia , Adulto , Idoso , Bases de Dados Factuais/estatística & dados numéricos , Feminino , Custos de Cuidados de Saúde/estatística & dados numéricos , Mortalidade Hospitalar , Humanos , Escala de Gravidade do Ferimento , Tempo de Internação/economia , Tempo de Internação/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Transtornos Relacionados ao Uso de Opioides/epidemiologia , Readmissão do Paciente/economia , Readmissão do Paciente/estatística & dados numéricos , Complicações Pós-Operatórias/economia , Complicações Pós-Operatórias/etiologia , Prevalência , Estudos Retrospectivos , Procedimentos Cirúrgicos Operatórios/estatística & dados numéricos , Fatores de Tempo , Ferimentos e Lesões/diagnóstico
7.
Surg Open Sci ; 6: 45-50, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34632355

RESUMO

BACKGROUND: Although significant racial disparities in the surgical management of lower extremity critical limb threatening ischemia have been previously reported, data on disparities in lower extremity acute limb ischemia are lacking. METHODS: The 2012-2018 National Inpatient Sample was queried for all adult hospitalizations for acute limb ischemia (N = 225,180). Hospital-specific observed-to-expected rates of major lower extremity amputation were tabulated. Multivariable logistic and linear models were developed to assess the impact of race on amputation and revascularization. RESULTS: Nonwhite race was associated with significantly increased odds of overall (adjusted odds ratio: 1.16, 95% confidence interval 1.06-1.28) and primary (adjusted odds ratio: 1.34, 95% confidence interval 1.17-1.53) major amputation, decreased odds of revascularization (adjusted odds ratio 0.79, 95% confidence interval 0.73-0.85), but decreased in-hospital mortality (adjusted odds ratio: 0.86, 95% confidence interval 0.74-0.99). The nonwhite group incurred increased adjusted index hospitalization costs (ß: +$4,810, 95% confidence interval 3,280-6,350), length of stay (ß: + 1.09 days, 95% confidence interval 0.70-1.48), and nonhome discharge (adjusted odds ratio: 1.15, 95% confidence interval 1.06-1.26). CONCLUSION: Significant racial disparities exist in the management of and outcomes of lower extremity acute limb ischemia despite correction for variations in hospital amputation practices and other relevant hospital and patient characteristics. Whether the etiology lies primarily in patient, institution, or healthcare provider-specific factors has not yet been determined. Further studies of race-based disparities in management and outcomes of acute limb ischemia are warranted to provide effective and equitable care to all.

8.
J Surg Res ; 267: 124-131, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34147002

RESUMO

Background Prior work has demonstrated inferior outcomes for a multitude of medical and surgical conditions at hospitals with high burdens of underinsured patients (safety-net). The present study aimed to evaluate trends in incidence, clinical outcomes and resource utilization in the surgical management of necrotizing soft-tissue infections (NSTI) at safety-net hospitals. Materials and methods Adults requiring surgical debridement/amputation following NSTI-related hospitalizations were identified in the 2005-2018 National Inpatient Sample. Safety-net status (SNH) was assigned to institutions in the top tertile for annual proportion of underinsured patients. Logistic multivariable regression was utilized to evaluate the association of SNH with mortality, hospitalization duration (LOS), costs and discharge disposition. Results Of an estimated 212,692 patients, 76,719 (36.1%) were managed at SNH. The annual incidence of NSTI admissions increased overall while associated mortality declined. After adjustment, SNH status was associated with greater odds of mortality (adjusted odds ratios: 1.14, 95% CI: 1.03-1.26), LOS (ß: +1.8 d, 95% CI: 1.3-2.2) and costs (ß: +$4,400, 95% CI: 2,900-5,800). SNH patients had similar rates of amputation but lower likelihood of care facility or home health discharge. Conclusion With a rising incidence and overall reduction in mortality, safety-net hospitals persistently exhibit greater mortality and resource use for surgical NSTI admissions. Variation in access, disease presentation and timeliness of operative intervention may explain the observed findings.


Assuntos
Fasciite Necrosante , Infecções dos Tecidos Moles , Adulto , Fasciite Necrosante/complicações , Fasciite Necrosante/epidemiologia , Fasciite Necrosante/cirurgia , Hospitalização , Hospitais , Humanos , Pacientes Internados , Estudos Retrospectivos , Provedores de Redes de Segurança , Infecções dos Tecidos Moles/complicações , Infecções dos Tecidos Moles/epidemiologia , Infecções dos Tecidos Moles/cirurgia
9.
Clin Transplant ; 35(8): e14389, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34154036

RESUMO

INTRODUCTION: The effect of the 2018 adult heart allocation policy change at an institution-level remains unclear. The present study assessed the impact of the policy change by transplant center volume. METHODS: The United Network for Organ Sharing database was queried for all adults undergoing isolated heart transplantation from November 2016 to September 2020. Era 1 was defined as the period before the policy change and Era 2 afterwards. Hospitals were divided into low-(LVC) medium-(MVC) and high-volume (HVC) tertiles based on annual transplant center volume. Competing-risks regressions were used to determine changes in waitlist death/deterioration, while post-transplant mortality was assessed using multivariable Cox proportional-hazards models. RESULTS: A total of 3531 (47.0%) patients underwent heart transplantation in Era 1 and 3988 (53.0%) in Era 2. At LVC, Era 2 patients were less likely to experience death/deterioration on the waitlist (subhazard ratio .74, 95% CI .63-.88), while MVC and HVC patients experienced similar waitlist death/deterioration across eras. After adjustment, transplantation in Era 2 was associated with worse 1-year mortality at MVC (hazard ratio, HR, 1.42 95% CI 1.02-1.96) and HVC (HR 1.42, 95% CI 1.02-1.98) but not at LVC. CONCLUSION: Early analysis shows that LVC may be benefitting under the new allocation scheme.


Assuntos
Transplante de Coração , Transplantes , Adulto , Humanos , Políticas , Modelos de Riscos Proporcionais , Listas de Espera
10.
Surgery ; 170(1): 304-310, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-33941388

RESUMO

BACKGROUND: While coding-based frailty tools may readily identify at-risk patients, they have not been adopted into screening guidelines for endovascular abdominal aortic aneurysm repair or thoracic endovascular aortic repair at the national level. We aimed to characterize the impact of frailty on clinical outcomes and resource use after endovascular aneurysm repair and thoracic endovascular aortic repair using a nationally representative cohort. METHODS: The 2005 to 2018 National Inpatient Sample was queried to identify all adults undergoing elective endovascular abdominal aortic aneurysm repair or thoracic endovascular aortic repair. Patients were considered "frail" if they suffered from any frailty-defining diagnoses in the Johns Hopkins Adjusted Clinical Groups. Multivariable regression models were used to identify independent associations with outcomes of interest including in-hospital mortality, nonhome discharge, and hospitalization costs. RESULTS: Of an estimated 301,869 patients, 273,415 (90.6%) underwent endovascular aneurysm repair and the remainder thoracic endovascular aortic repair. Frailty prevalence was lower in the endovascular aneurysm repair cohort (2.3%) compared with thoracic endovascular aortic repair (4.7%). After adjustment, frailty was associated with higher in-hospital mortality (endovascular aneurysm repair odds ratio 4.0; thoracic endovascular aortic repair odds ratio 2.5), nonhome discharge rates (endovascular aneurysm repair odds ratio 7.2; thoracic endovascular aortic repair odds ratio 4.2), and predicted costs (endovascular aneurysm repair ß coefficient +$10.6K; thoracic endovascular aortic repair ß coefficient +$38.2K) for both cohorts. CONCLUSION: Given that frailty portends inferior outcomes for both endovascular aneurysm repair and thoracic endovascular aortic repair, its inclusion in existing risk models may better inform shared decision-making.


Assuntos
Aorta Torácica/cirurgia , Aneurisma Aórtico/cirurgia , Procedimentos Endovasculares , Fragilidade/complicações , Resultado do Tratamento , Idoso , Aneurisma da Aorta Abdominal/cirurgia , Procedimentos Cirúrgicos Eletivos , Procedimentos Endovasculares/efeitos adversos , Feminino , Idoso Fragilizado , Mortalidade Hospitalar , Humanos , Masculino , Razão de Chances , Complicações Pós-Operatórias/etiologia , Medição de Risco/métodos , Fatores de Risco
11.
Surgery ; 170(1): 257-262, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-33775395

RESUMO

BACKGROUND: Surgical re-exploration after lung resection remains poorly characterized, although institutional series have previously reported its association with greater mortality and complications. The present study sought to examine the impact of institutional lung-resection volume on the incidence of and short-term outcomes after surgical re-exploration. METHODS: The 2007 to 2018 National Inpatient Sample was used to identify all adults who underwent lobectomy or pneumonectomy. Hospitals were divided into tertiles based on institutional lung-resection caseload. Multivariable regressions were used to identify associations between independent covariates on clinical outcomes. RESULTS: Of an estimated 329,273 patients, 3,592 (1.09%) were re-explored with decreasing incidence over time. Open and minimal access pneumonectomy among other factors were associated with greater odds of reoperation. Those re-explored had greater odds of mortality and complications as well as increased duration of stay and adjusted costs. Although risk of re-exploration was similar across hospital tertiles, reoperative mortality was significantly lower at high-volume hospitals. CONCLUSION: Re-exploration after lung resection is uncommon; however, when occurring, it is associated with worse clinical outcomes. After re-exploration, high-volume center status was associated with reduced odds of mortality relative to low volume. Failure to rescue at lower-volume centers suggests the need for optimization of perioperative factors to decrease incidence of reoperation.


Assuntos
Pneumopatias/cirurgia , Pneumonectomia/mortalidade , Reoperação/mortalidade , Idoso , Feminino , Hospitais com Alto Volume de Atendimentos , Hospitais com Baixo Volume de Atendimentos , Humanos , Pneumopatias/mortalidade , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Análise de Regressão , Reoperação/estatística & dados numéricos , Falha de Tratamento , Estados Unidos/epidemiologia
12.
Chest ; 160(1): 165-174, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-33617805

RESUMO

BACKGROUND: Despite the frequency and cost of hospitalizations for acute respiratory failure (ARF), the literature regarding the impact of hospital safety net burden on outcomes of these hospitalizations is sparse. RESEARCH QUESTION: How does safety net burden impact outcomes of ARF hospitalizations such as mortality, tracheostomy, and resource use? STUDY DESIGN AND METHODS: This was a retrospective cohort study using the National Inpatient Sample 2007-2017. All patients hospitalized with a primary diagnosis of ARF were tabulated using the International Classification of Diseases 9th and 10th Revision codes, and safety net burden was calculated using previously published methodology. High- and low-burden hospitals were generated from proportions of Medicaid and uninsured patients. Trends were analyzed using a nonparametric rank-based test, whereas multivariate logistic and linear regression models were used to establish associations of safety net burden with key clinical outcomes. RESULTS: Of an estimated 8,941,334 hospitalizations with a primary diagnosis of ARF, 33.9% were categorized as occurring at low-burden hospitals (LBHs) and 31.6% were categorized as occurring at high-burden hospitals (HBHs). In-hospital mortality significantly decreased at HBHs (22.8%-12.6%; nonparametric trend [nptrend] < .001) and LBHs (22.0%-10.9%; nptrend < .001) over the study period, as did tracheostomy placement (HBH, 5.6%-1.3%; LBH, 3.5%-0.8%; all nptrend <.001). After adjustment for patient and hospital factors, an HBH was associated with increased odds of mortality (adjusted OR [AOR], 1.11; 95% CI, 1.10-1.12) and tracheostomy use (AOR, 1.33; 95% CI, 1.29-1.37), as well as greater hospitalization costs (ß coefficient, +$1,083; 95% CI, $882-$1,294) and longer lengths of stay (ß coefficient, +3.3 days; 95% CI, 3.2-3.3 days). INTERPRETATION: After accounting for differences between patient cohorts, high safety net burden was associated independently with inferior clinical outcomes and increased costs after ARF hospitalizations. These findings emphasize the need for health care reform to ameliorate disparities within these safety net centers, which treat our most vulnerable populations.


Assuntos
Recursos em Saúde/estatística & dados numéricos , Custos Hospitalares/tendências , Insuficiência Respiratória/epidemiologia , Provedores de Redes de Segurança/economia , Doença Aguda , Idoso , Feminino , Seguimentos , Mortalidade Hospitalar/tendências , Humanos , Masculino , Medicaid/economia , Insuficiência Respiratória/economia , Insuficiência Respiratória/terapia , Estudos Retrospectivos , Estados Unidos/epidemiologia
13.
J Transl Med ; 9: 65, 2011 May 16.
Artigo em Inglês | MEDLINE | ID: mdl-21575250

RESUMO

BACKGROUND: The differential diagnosis for hereditary ataxia encompasses a variety of diseases characterized by both autosomal dominant and recessive inheritance. There are no curative treatments available for these neurodegenerative conditions. This open label treatment study used human umbilical cord blood-derived mononuclear cells (CBMC) combined with rehabilitation training as potential disease modulators. METHODS: 30 patients suffering from hereditary ataxia were treated with CBMCs administered systemically by intravenous infusion and intrathecally by either cervical or lumbar puncture. Primary endpoint measures were the Berg Balance Scale (BBS), serum markers of immunoglobulin and T-cell subsets, measured at baseline and pre-determined times post-treatment. RESULTS: A reduction of pathological symptoms and signs was shown following treatment. The BBS scores, IgG, IgA, total T cells and CD3+CD4 T cells all improved significantly compared to pre-treatment values (P < 0.01~0.001). There were no adverse events. CONCLUSION: The combination of CBMC infusion and rehabilitation training may be a safe and effective treatment for ataxia, which dramatically improves patients' functional symptoms. These data support expanded double blind, placebo-controlled studies for these treatment modalities.


Assuntos
Transplante de Células , Sangue Fetal/citologia , Leucócitos Mononucleares/transplante , Degenerações Espinocerebelares/terapia , Adulto , Idoso , Feminino , Humanos , Imunoglobulinas/imunologia , Masculino , Pessoa de Meia-Idade , Degenerações Espinocerebelares/imunologia , Subpopulações de Linfócitos T/imunologia , Resultado do Tratamento , Adulto Jovem
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