RESUMO
Naringenin belongs to the flavanones and is mainly found in fruits (grapefruit and oranges) and vegetables. Naringenin exhibits lipid-lowering and insulin-like characteristics and is used to treat osteoporosis, cancer and cardiovascular disorders. Their incorporation into drug formulations offers several advantages, including enhanced solubility, improved bioavailability and targeted delivery. Naringin-based formulations are beneficial in cancer, for example controlling breast and prostate cancer by inhibition of CYP19. Naringin suppresses the PI3K/AKT signalling pathway, it triggers autophagy, which effectively halts the proliferation of gastric cancer cells. Naringin and naringenin co-administration or pre-administration has enhanced the target drug's potency and produced a synergistic effect. This published study demonstrates the potential applications of Naringin and Naringenin as recognized bio-enhancers.
This work investigates the possible uses of Naringenin, a substance found in fruits such as grapefruit and oranges. Naringenin has some exciting qualities it can help lower lipids (fats), act similarly to insulin, and has the potential to fight cancer. Because of these properties, it could be helpful in treating conditions like osteoporosis, cancer, and heart problems. When we include Naringenin in medicine formulations, it can have benefits such as being easier to dissolve, getting absorbed better by the body, and reaching specific target areas effectively.
