RESUMO
Hyaluronic acid (HA) plays a vital role in cellular processes and its contribution to physical and immunological barriers is considered to be an important property for the formulation of modern therapeutics. With the increasing demand for non-toxic and targeted therapy, HA-based materials could be utilized for biomedical applications due to their tendency to bio-mimic the hosts. Moreover, HA is a versatile compound in the fabrication of HA-based products such as hydrogels, nanofibers, and 3D materials. These have been implemented in various medical fields, such as bone and tissue regeneration, topical gels for wound healing, and cancer treatment via HA-loaded drug delivery approaches. Herein, we have discussed the characteristics of HA and its significance in drug delivery in addition to synergistic effects with other therapeutic compounds in the fields of nanomedicine, tissue engineering, and regenerative medicine.
Assuntos
Medicina Regenerativa , Engenharia Tecidual , Ácido Hialurônico/uso terapêutico , Nanomedicina , Hidrogéis/uso terapêuticoRESUMO
The hazardous risk posed by industrial effluent discharge into the ecosystem has raised a plethora of environmental issues, public health, and safety concerns. The effluents from industries such as tanning, leather, petrochemicals, pharmaceuticals, and textiles are create significant stress on the aquatic ecosystem, which induces significant toxicity, involved in endocrine disruptions, and inhibits reproductive functions. Therefore, this review presented an overall abridgment of the effects of these effluents and their ability to synergize with modern pollutants such as pharmaceuticals, cosmetic chemicals, nanoparticles, and heavy metals. We further emphasize the metal organic framework (MOF) based membrane filtration approach for remediation of industrial effluents in comparison to the traditional remediation process. The MOF based-hybrid membrane filters provide higher reusability, better adsorption, and superior removal rates through the implication of nanotechnology, while the traditional remediation process offers poorer filtration rates and stability.