[Repeated immune response in gnotobiotic rats]. / Osobennosti povtornogo immunnogo otveta u krys-gnotobiontov

Repeated immune response to diphtheria toxoid was investigated in monocontaminated rats. It was shown that repeated immunization of these animals led to a sufficiently intensive immune response by the secondary type, but it ended much earlier than in the usual animals (by the 12th day). A supposition is put forward that earlier termination of the secondary response in gnotobionts is caused by the absence in their lymph nodes of an additional differentiation of cell-precursors at the late periods of secondary immune response.

[Characteristics of the immunomorphological substrate in secondary immunization as dependent on the functional state of the hypothalamic nuclei]. / Ob osobennostiakh immuno-morfologicheskogo substrata pri vtorichnoi immunizatsii v zavisimosti ot funktsional'nogo sostoianiia iader gipotalamusa

The authors traced the morphological and serological shifts occurring in secondary immunological response against the background of destruction of the posterior hypothalamic nuclei. It was revealed in experiments on rabbits that in primary and secondary immunization carried out against the background of bilateral coagulation of the posterior hypothalamic nucleus the secondary immunological response was reduced in comparison with control. Depression occurred both on account of reduction of the number of cells-precursors, and in connection with disturbances of differentiation of the antibody-forming cells. When the primary immunization was conducted against the background of the intact brain, and destruction of the posterior hyfothalamic nuclei preceded the secondary immunization there occurred a change in the number of cells-precursors involved in differentiation, without disturbance of the differentiation itself.