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RESUMO

The dynamics of gene expression of two proteins, TLR9 (one of the key receptors recognizing CpG repeats of herpes virus DNA) and ß-defensin 2 (antibacterial peptide), was studied on the model of herpetic keratitis in C57Bl/6 and BALB/c mice. New data on differences in TLR9 gene expression in mice of the two strains infected with the virus were obtained. Reduced TLR9 gene expression in the cornea of C57Bl/6 mice was associated with their high sensitivity to infection caused by herpes simplex 1 virus.

Assuntos

Córnea/metabolismo , Expressão Gênica , Ceratite Herpética/genética , Ceratite Herpética/imunologia , Receptor Toll-Like 9/genética , beta-Defensinas/genética , Sequência de Aminoácidos , Animais , Córnea/imunologia , Córnea/virologia , Herpes Simples , Imunidade Inata , Ceratite Herpética/metabolismo , Ceratite Herpética/virologia , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos C57BL , Dados de Sequência Molecular , RNA Mensageiro/genética , RNA Mensageiro/metabolismo , Receptor Toll-Like 9/química , Receptor Toll-Like 9/metabolismo , beta-Defensinas/metabolismo

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