RESUMO
Introduction: This study aimed to investigate the impact of a 10-week Core Stability Training (CST) compared to Traditional Strength Training (TST) on the balance abilities of adolescent male basketball players. Methods: Subjects (age: 15.70 ± 0.75, height: 178.4 ± 8.31, weight: 66.55 ± 8.34) were randomly assigned to either the Core Stability Training group or the Traditional Strength Training group. Three selected balance assessment indicators included the Single-leg Standing with Eyes Closed Test, Star Excursion Balance Test, and Core Four-Direction Endurance Test. Results: 1) The scores were significantly different in both groups before and after the Single-leg Standing with Eyes Closed Test; (p < 0.01, d = 1.692, d = 1.837); 2) In the Star Excursion Balance Test, the scores of the experimental group showed significant difference (p < 0.05) or highly significant difference (p < 0.01) with an average effect size of (d = 1.727) when the left or right foot supported in the other directions before and after the training. However, there was no significant difference in scores in the c direction when the left foot supported (p > 0.05, d = 0.954); 3) In the Core Four-Direction Endurance Test, there were no significant differences in scores for the control group before and after training (p > 0.05, d = 0.567), while the experimental group showed significant differences in scores before and after training (p < 0.05, d = 1.889). Discussion: Both CST and TST were effective in enhancing the balance abilities of adolescent basketball players. CST, in particular, demonstrated improvements in dynamic balance and agility across multiple planes. Basketball coaches are encouraged to consider incorporating CST training programs into their overall training plans for optimal balance enhancement.
RESUMO
With great interest, we read the recent article entitled "Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk in Chinese population: a meta-analysis of 22 case-control studies" published online in Tumor Biology, 2014, 35: 1695-1701. This article suggests that methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism was significantly associated with breast cancer risk in Chinese population. The result is encouraging. Nevertheless, three key issues in this meta-analysis are worth noticing.
Assuntos
Neoplasias da Mama/genética , Estudos de Associação Genética , Metilenotetra-Hidrofolato Redutase (NADPH2)/genética , Povo Asiático , Neoplasias da Mama/patologia , China , Feminino , Predisposição Genética para Doença , Genótipo , Humanos , Polimorfismo de Nucleotídeo Único , Fatores de RiscoRESUMO
The purpose of this study was to explore the expression of TG-interacting factor (TGIF) in lung carcinogenesis. Malignant transformation of human bronchial epithelial (16HBE) cell was established by benzo(a)pyrene (BaP) treatment. Soft agar assay and tumor formation assay in nude mice were applied. Tumorigenesis experiment in vivo was done by BaP treatment. Western blotting, immunohistochemistry, and quantitative polymerase chain reaction were used to detect TGIF expression. We observed a higher level of TGIF messenger RNA (mRNA) in lung cancer tissues than that in paracancerous tissues. We observed significantly higher levels of TGIF mRNA and protein in A549 and H1299 cell lines than that in 16HBE cell. Increased expressions of TGIF protein and mRNA were observed in 16HBE cells induced by BaP treatment as compared to those in solvent control group. We observed significantly higher levels of TGIF mRNA and protein in 16HBE-BaP cells than that in 16HBE-control cells. We observed significantly higher levels of TGIF mRNA and protein in mice lung tissues treated with BaP than that in control group. Our results suggested that elevated expression of TGIF was involved in lung carcinogenesis.
Assuntos
Carcinogênese/genética , Proteínas de Homeodomínio/biossíntese , Neoplasias Pulmonares/genética , Neoplasias Pancreáticas/genética , Proteínas Repressoras/biossíntese , Animais , Apoptose/genética , Benzo(a)pireno/toxicidade , Brônquios/efeitos dos fármacos , Brônquios/patologia , Carcinogênese/patologia , Linhagem Celular Tumoral , Proliferação de Células/genética , Regulação Neoplásica da Expressão Gênica , Proteínas de Homeodomínio/genética , Humanos , Neoplasias Pulmonares/induzido quimicamente , Neoplasias Pulmonares/patologia , Camundongos , Neoplasias Pancreáticas/patologia , Proteínas Repressoras/genética , Ensaios Antitumorais Modelo de XenoenxertoRESUMO
Recently, we have read with great interest the article entitled "The association between polymorphisms in the leptin receptor (LEPR) gene and risk of breast cancer: a systematic review and pooled analysis" published online by Wang et al. (Breast Cancer Res Treat 136:231-239, 2012). This article suggests that the A allele of LEPR gene rs1137101 variant was low-penetrant risk factor for developing breast cancer. The result is encouraging. Nevertheless, several key issues are worth noticing.
