[Effect of trans-ACPD, a specific agonist of glutamate interacting with metabotropic receptors, on synaptic transmission in the rat hippocampus]. / Vliianie trans-ASPD--spetsificheskogo agonista glutamata, vzaimodeistvuiushchego s metabotropnymi retseptorami, na sinapticheskuiu peredachu v gippokampe krys.

Trans-ACPD, a cyclic analogue of glutamate, has been studied for its influence on field potentials and excitatory postsynaptic currents (EPSCs) in the CA1 layer. Being applied in concentration 50 microM and above, trans-ACPD completely and reversibly inhibited excitatory postsynaptic field potentials but has no effect on EPSCs. Trans-ACPD in the same concentration reversibly reduced the amplitude of antidromic population spike in the CA1 layer, but has an insignificant effect on antidromic population spike in the CA3 layer.

[Analysis of synaptic transmission in rat hippocampal slices using a modified method of potential fixation]. / Issledovanie sinapticheskoi peredachi v srezakh gippokampa krys s primeneniem modifitsirovannoi metodiki fiksatsii potentsiala.

A new approach for the whole-cell recording in slices is suggested as simpler and less expensive one than those known before. Electrophysiological characteristics of excitatory postsynaptic currents are obtained. Two types of glutamate receptors are shown to be involved. The kynurenic acid is proved to exert more prominent effect on the NMDA-receptor mediated current. Biphasic action of adenosine, a wide spread neuromodulator, on synaptic transmission is shown.