RESUMO
The results of comprehensive study of clinical, hematological, immunological, and bacteriological parameters in irradiated rats and dogs are presented. There is a growth of the automicroflora with decreases in leukocytes by 30-40%, lysozyme, beta-lysine, phagocytosis, total serum bactericidal activity by 10-20%. The appearance of pathogenic properties and resistance of Escherichia coli to antibiotics was observed with 60-70% reductions in the activity of nonspecific antiinfectious resistance and with 75-85% falls in neutrophils. This causes clinical manifestations of infectious complications. The appearance of hemolytic properties of Escherichia coli promotes the development of hemorrhagic complications at the sites of its natural habitation. The changes found in different periods after irradiation in the hematologic, immunological, and particularly bacteriological parameters may be criteria for predicting infectious complications and using therapeutical features in time.
Assuntos
Infecções por Escherichia coli/diagnóstico , Lesões Experimentais por Radiação/complicações , Animais , Antibacterianos/uso terapêutico , Anticorpos Antibacterianos/imunologia , Anticorpos Antibacterianos/efeitos da radiação , Contagem de Colônia Microbiana , Cães , Escherichia coli/crescimento & desenvolvimento , Escherichia coli/imunologia , Escherichia coli/efeitos da radiação , Infecções por Escherichia coli/tratamento farmacológico , Infecções por Escherichia coli/etiologia , Seguimentos , Linfócitos/imunologia , Linfócitos/efeitos da radiação , Masculino , Prognóstico , Lesões Experimentais por Radiação/imunologia , RatosRESUMO
The bone marrow eosinophils of rats subjected to irradiation are capable of secreting a peroxidase system obtained by neutrophils and endotheliocytes. As a result, there appear heterophil granulocytes in the peripheral blood.
