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1.
Mar Environ Res ; 197: 106478, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38594093

RESUMO

Increasing impacts of both fisheries and climate change have resulted in shifts in the structure and functioning of marine communities. One recurrent observation is the rise of cephalopods as fish recede. This is generally attributed to the removal of main predators and competitors by fishing, while mechanistic evidence is still lacking. In addition, climate change may influence cephalopods due to their high environmental sensitivity. We aim to unveil the effects of different anthropogenic and environmental drivers at different scales focusing on the cephalopod community of the Western Mediterranean Sea. We investigate several ecological indicators offering a wide range of information about their ecology, and statistically relating them with environmental, biotic and fisheries drivers. Our results highlight non-linear changes of indicators along with spatial differences in their responses. Overall, the environment drivers have greater effects than biotic and local human impacts with contrasting effects of temperature across the geographic gradient. We conclude that cephalopods may be impacted by climate change in the future while not necessary through positive warming influence, which should make us cautious when referring to them as generalized winners of current changes.


Assuntos
Cefalópodes , Ecossistema , Animais , Humanos , Cefalópodes/fisiologia , Mar Mediterrâneo , Mudança Climática , Pesqueiros
2.
Healthcare (Basel) ; 12(5)2024 Mar 06.
Artigo em Inglês | MEDLINE | ID: mdl-38470709

RESUMO

This study addresses the health-related quality of life (HRQoL) of Spanish nurses during the sixth wave of the COVID-19 pandemic, assessed through the EQ-5D and EQ-VAS indices. METHODS: This cross-sectional 334 study used online surveys, recruiting 305 Spanish nurses. RESULTS: Nurses generally perceived a good HRQoL. "Negative work-family interaction" is adversely associated with the EQ-VAS (ß = -0.337, 95% CI [-1.733, -0.723]) and EQ-5D (ß = -0.399, 95% CI [-0.021, -0.01]) indices, while "positive work-family interaction" shows a positive relationship with the EQ-VAS (ß = 0.218, 95% CI [0.381, 1.759]). The presence of a "paid supportive caregiver" is positively associated with the EQ-VAS (ß = 0.18, 95% CI [1.47, 12.3]) and EQ-5D (ß = 0.149, 95% CI [0.004, 0.117]) indices, but a higher "number of children" is negatively linked with the EQ-5D index (ß = -0.146, 95% CI [-0.061, -0.002]). In addition, living with a partner (EQ-VAS ß = 0.16, 95% CI [1.094, 14.67] and EQ-5D index ß = 0.174, 95% CI [0.018, 0.163]) and working a "rotating shift" (EQ-5D index ß = 0.158, 95% CI [0.005, 0.098]) are positively associated. CONCLUSIONS: These findings highlight the need to comprehensively address nurses' well-being, considering both their working conditions and their home environment, especially in crisis contexts such as the current pandemic.

3.
BMC Nurs ; 22(1): 245, 2023 Jul 27.
Artigo em Inglês | MEDLINE | ID: mdl-37496059

RESUMO

BACKGROUND: One of the environments where people living with HIV/AIDS should feel safer is in the health care setting; however, scientific evidence has identified discriminatory behaviour on the part of health care professionals towards these people. The reduction or abolition of discriminatory practices requires, first of all, to know the attitudes of nursing students towards AIDS with tools appropriate to the socio-cultural context of the disease. The objectives of this study are to update the AIDS Attitudes Scale for Nursing Students (EASE) by adapting it to the sociocultural landscape and to analyse the reliability and structural validity of the new scale. METHODS: The results of the questionnaires answered by 213 undergraduate nursing students from the Faculty of Health Sciences of Ceuta (University of Granada) were analysed. Reliability (test-retest, n = 33) and validity (n = 180) tests were carried out. RESULTS: An exploratory and confirmatory factor analysis indicated that a four-factor model was the most parsimonious solution. Items were examined for their underlying relationships and labelled: professional practice, social integration, partner and family, and benevolent stigma. The new scale yielded a McDonald's Omega coefficient (ω) of 0.893. Convergent validity was established for average variance extracted per factor greater than 0.5 and divergent validity when the variance retained by each factor is greater than the variance shared between them (average variance extracted per factor > ϕ2). CONCLUSIONS: The new scale is a psychometrically sound instrument for assessing attitudes towards people living with HIV/AIDS in nursing students.

4.
Breast Cancer Res ; 25(1): 72, 2023 06 20.
Artigo em Inglês | MEDLINE | ID: mdl-37340476

RESUMO

INTRODUCTION: Height, body mass index (BMI), and weight gain are associated with breast cancer risk in the general population. It is unclear whether these associations also exist for carriers of pathogenic variants in the BRCA1 or BRCA2 genes. PATIENTS AND METHODS: An international pooled cohort of 8091 BRCA1/2 variant carriers was used for retrospective and prospective analyses separately for premenopausal and postmenopausal women. Cox regression was used to estimate breast cancer risk associations with height, BMI, and weight change. RESULTS: In the retrospective analysis, taller height was associated with risk of premenopausal breast cancer for BRCA2 variant carriers (HR 1.20 per 10 cm increase, 95% CI 1.04-1.38). Higher young-adult BMI was associated with lower premenopausal breast cancer risk for both BRCA1 (HR 0.75 per 5 kg/m2, 95% CI 0.66-0.84) and BRCA2 (HR 0.76, 95% CI 0.65-0.89) variant carriers in the retrospective analysis, with consistent, though not statistically significant, findings from the prospective analysis. In the prospective analysis, higher BMI and adult weight gain were associated with higher postmenopausal breast cancer risk for BRCA1 carriers (HR 1.20 per 5 kg/m2, 95% CI 1.02-1.42; and HR 1.10 per 5 kg weight gain, 95% CI 1.01-1.19, respectively). CONCLUSION: Anthropometric measures are associated with breast cancer risk for BRCA1 and BRCA2 variant carriers, with relative risk estimates that are generally consistent with those for women from the general population.


Assuntos
Neoplasias da Mama , Genes BRCA2 , Adulto , Feminino , Humanos , Índice de Massa Corporal , Proteína BRCA1/genética , Neoplasias da Mama/epidemiologia , Neoplasias da Mama/genética , Neoplasias da Mama/patologia , Proteína BRCA2/genética , Risco , Estudos Retrospectivos , Aumento de Peso/genética , Heterozigoto , Predisposição Genética para Doença
5.
Midwifery ; 124: 103749, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-37271065

RESUMO

OBJECTIVE: To assess the attitudes and care practices of midwives and nurses in the province of Granada in relation to death care and perinatal bereavement, to determine their degree of adaptation to international standards and to identify possible differences in personal factors among those who best adapt to international recommendations. DESIGN: A local survey of 117 nurses and midwives from the five maternity hospitals in the province was conducted using the Lucina questionnaire developed to explore professionals' emotions, opinions, and knowledge during perinatal bereavement care. Adaptation of practices to international recommendations was assessed using the CiaoLapo Stillbirth Support (CLASS) checklist. Socio-demographic data were collected to establish their association with increased compliance with recommendations. FINDINGS: The response rate was 75.4%, the majority were women (88.9%), with a mean age of 40.9 (SD=1.4) and 17.4 (SD= 10.58) years of work experience. Midwives were the most represented (67.5%) and reported having attended more cases of perinatal death (p = 0.010) and having more specific training (p<0.001.) Of these, 57.3% would recommend immediate delivery, 26.5% would recommend the use of pharmacological sedation during delivery and 47% would take the baby immediately if the parents expressed their wish not to watch them. On the other hand, only 58% would be in favour of taking photos for the creation of memories, 47% would bathe and dress the baby in all cases, and 33.3% would allow the company of other family members. The percentage that matched each recommendation on memory-making was 58%, 41.9% matched the recommendations on respect for the baby and parents, and 23% and 10.3% matched the appropriate delivery and follow-up options, respectively. The factors associated with 100% of the recommendations, according to the care sector, were being a woman, a midwife, having specific training and having personally experienced the situation. KEY CONCLUSIONS: Although the levels of adaptation observed are more favourable than in other nearby contexts, serious deficiencies are identified in the province of Granada with respect to internationally agreed recommendations on perinatal bereavement care. More training and awareness-raising of midwives and nurses is needed, which also considers factors related to better compliance. IMPLICATION FOR PRACTICE: This is the first study to quantify the degree of adaptation to international recommendations in Spain reported by midwives and nurses, as well as the individual factors associated with a higher level of compliance. Areas for improvement and explanatory variables of adaptation are identified, which allow support for possible training and awareness-raising programmes aimed at improving the quality of care provided to bereaved families.


Assuntos
Luto , Cuidados Paliativos na Terminalidade da Vida , Feminino , Humanos , Masculino , Gravidez , Adulto , Cuidados Paliativos na Terminalidade da Vida/psicologia , Maternidades , Espanha , Pesar , Natimorto/psicologia , Pais/psicologia
6.
Pathogens ; 12(6)2023 May 24.
Artigo em Inglês | MEDLINE | ID: mdl-37375446

RESUMO

Epidemiological data on women suffering from vulvovaginal candidiasis and its recurrence are outdated and vague. The aim of this study was to identify the prevalence of women diagnosed with vulvovaginal candidiasis, as well as the epidemiological profile and associated risk factors in the province of Granada (Spain). Data from the Centre for Sexually Transmitted Infections of the Granada province between 2000 and 2018 (N = 438) were used in this study. Associations between sociodemographic and sexual behaviour variables with vulvovaginal candidiasis were analysed using the Chi-square test and bivariate logistic regression. The prevalence of candidiasis was 14.6%. The sociodemographic profile corresponded to a woman aged 25.14 ± 4.8 years on average, who is of Spanish nationality (60.9%), a student (55.7%), in non-active employment (59.7%), with a higher education (56.7%), single (93.5%), and under 30 years of age (79.7%). Variables associated with this diagnosis were the absence of oro-genital contact (OR = 1.99; 95% CI = 0.25-0.74), having a regular partner (OR = 1.99; 95% CI = 1.05-3.75), and age of sexual debut, with the probability increasing by 12% (95% CI = 1.00-1.24) with each year. In this context, vulvovaginal candidiasis infection is common, and its epidemiological profile is contradictory, so our results do not suggest a relevant role of sexual risk behaviours in the diagnosis. Further research is needed to improve the estimates and factors associated with this infection.

7.
J Natl Cancer Inst ; 115(11): 1318-1328, 2023 11 08.
Artigo em Inglês | MEDLINE | ID: mdl-37369040

RESUMO

BACKGROUND: Radiation-induced secondary breast cancer (BC) may be a concern after radiation therapy (RT) for primary breast cancer (PBC), especially in young patients with germline (g)BRCA-associated BC who already have high contralateral BC (CBC) risk and potentially increased genetic susceptibility to radiation. We sought to investigate whether adjuvant RT for PBC increases the risk of CBC in patients with gBRCA1/2-associated BC. METHODS: The gBRCA1/2 pathogenic variant carriers diagnosed with PBC were selected from the prospective International BRCA1/2 Carrier Cohort Study. We used multivariable Cox proportional hazards models to investigate the association between RT (yes vs no) and CBC risk. We further stratified for BRCA status and age at PBC diagnosis (<40 and >40 years). Statistical significance tests were 2-sided. RESULTS: Of 3602 eligible patients, 2297 (64%) received adjuvant RT. Median follow-up was 9.6 years. The RT group had more patients with stage III PBC than the non-RT group (15% vs 3%, P < .001), received chemotherapy more often (81% vs 70%, P < .001), and received endocrine therapy more often (50% vs 35%, P < .001). The RT group had an increased CBC risk compared with the non-RT group (adjusted hazard ratio [HR] = 1.44; 95% confidence interval [CI] = 1.12 to 1.86). Statistical significance was observed in gBRCA2 (HR = 1.77; 95% CI = 1.13 to 2.77) but not in gBRCA1 pathogenic variant carriers (HR = 1.29; 95% CI = 0.93 to 1.77; P = .39 for interaction). In the combined gBRCA1/2 group, patients irradiated when they were younger than or older than 40 years of age at PBC diagnosis showed similar risks (HR = 1.38; 95% CI = 0.93 to 2.04 and HR = 1.56; 95% CI = 1.11 to 2.19, respectively). CONCLUSIONS: RT regimens minimizing contralateral breast dose should be considered in gBRCA1/2 pathogenic variant carriers.


Assuntos
Neoplasias da Mama , Humanos , Feminino , Neoplasias da Mama/genética , Neoplasias da Mama/radioterapia , Neoplasias da Mama/tratamento farmacológico , Proteína BRCA1/genética , Estudos de Coortes , Estudos Prospectivos , Proteína BRCA2/genética
8.
Curr Psychol ; : 1-10, 2023 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-37359590

RESUMO

Pregnancy and/or the puerperium involve social, physiological and psychological changes that make women more vulnerable to mental disorders such as anxiety and depression, even more so if these develop in stressful contexts such as the pandemic. The aim of this study is to identify factors associated with the risk of postpartum anxiety and depression during the COVID-19 pandemic. A cross-sectional study was conducted among postpartum women (n = 69) who gave birth between March 2020 and March 2021 in Melilla, a Spanish cross-border city with Morocco whose borders were closed, making it a confined city. The scales used were the State-Trait Anxiety Inventory and the Edinburgh Postnatal Depression Scale. Results reported an elevated risk of depression (85.5%) and anxiety (63.8%), with severe anxiety reaching 40.6% of cases. Predictors of postpartum depression comprised a personal history of mood disorders (ß = 8.421; CI95% = 4.863/11.978) and having been diagnosed with COVID-19 during pregnancy or postpartum (ß = 4.488; CI95% = 1.331/7.646). As regards anxiety, it is predicted on the basis of mood antecedents (ß = 14.175; CI95% = 7.870/20.479), the fact of having been diagnosed with COVID-19 during pregnancy or postpartum (ß = 8.781; CI95% = 2.970/14.592) and the fact of being a multipara (ß = 5.513; CI95% = 0.706/10.321). In conclusion, special attention should be paid to women with a history of mood disorders and a positive diagnosis of COVID-19 during pregnancy or postpartum, even more so in the case of multiparous women, because of its impact on mental health during the postpartum period. Supplementary Information: The online version contains supplementary material available at 10.1007/s12144-023-04719-6.

9.
Rev. adm. pública (Online) ; 57(1): 0-0168, jan.-fev. 2023. tab, graf
Artigo em Português | LILACS | ID: biblio-1431417

RESUMO

Resumo O presente artigo compara os modelos e as desigualdades territoriais no financiamento de duas políticas sociais pilares do estado de bem-estar social e com alto grau de descentralização territorial na Espanha e no Brasil: educação e saúde. A análise utiliza bibliografia especializada, legislação nacional e documentos governamentais para descrever as políticas e seus mecanismos de financiamento. Dados fiscais são usados para apresentar os gastos e analisar as desigualdades dos governos subnacionais no financiamento da educação e da saúde nos dois países. A conclusão é que a experiência espanhola apresenta elevado nivelamento de gastos em saúde e educação nas comunidades autônomas do regime comum, com patamares menores de desigualdade que o observado nos estados e municípios brasileiros. O resultado espanhol é decorrente de um processo incremental de aperfeiçoamento do federalismo fiscal, que culminou em um modelo marcado pela priorização e solidariedade territorial no financiamento das políticas sociais. Esse modelo é uma referência para a análise e discussão do caso brasileiro, que configurou seu federalismo fiscal com pouca preocupação em conciliar eficiência e equidade na distribuição dos recursos entre os entes governamentais, mas apresentou avanços importantes em reformas no financiamento da educação e da saúde.


Resumen El artículo compara los modelos y las desigualdades territoriales en la financiación de dos políticas sociales que son pilares del estado de bienestar y con un alto grado de descentralización territorial en España y Brasil: la educación y la sanidad. El análisis utiliza literatura especializada, legislación nacional y documentos gubernamentales para describir las políticas y sus mecanismos de financiación. Los datos fiscales se utilizan para analizar las desigualdades de los gobiernos subnacionales en la financiación de la educación y la sanidad en ambos países. La conclusión es que la experiencia española muestra una alta nivelación del gasto en salud y educación en las comunidades autónomas de régimen común, con niveles de desigualdad inferiores a los observados en los estados y municipios brasileños. El resultado español es fruto de un proceso de mejora y perfeccionamiento del federalismo fiscal que culminó en un modelo marcado por la priorización y la solidaridad territorial en la financiación de las políticas sociales. Este modelo es una referencia para el análisis y la discusión del caso brasileño, que ha configurado su federalismo fiscal con poca preocupación por conciliar la eficiencia y la equidad en la distribución de los recursos entre las entidades gubernamentales, pero que ha presentado importantes avances en las reformas de la financiación de la educación y la sanidad.


Abstract The article compares the patterns and territorial inequalities in the funding of two social policies that are pillars of the welfare state and present a high degree of territorial decentralization in Spain and Brazil: education and health. The analysis uses specialist literature, national legislation and government documents to describe the policies and their financing mechanisms. Fiscal data are used to analyze subnational government inequalities in the funding of education and health in both countries. The conclusion is that the Spanish experience has significantly leveled spending on health and education between the autonomous communities of common regime, with lower levels of inequality than those observed in Brazilian states and municipalities. The Spanish result derives from an incremental process of improvement of the country's fiscal federalism, which culminated in a model marked by prioritization and territorial solidarity in the funding of social policies. This model is reference for the analysis and discussion of the Brazilian case, which has configured its fiscal federalism with little concern for reconciling efficiency and equity in the distribution of resources between subnational governments, but which has presented important advances in the reforms of education and health funding.


Assuntos
Política Pública , Fatores Socioeconômicos , Espanha , Brasil , Saúde , Educação
10.
Mar Environ Res ; 184: 105844, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36603343

RESUMO

Fish body condition and growth are two interrelated traits closely associated with species life history and fitness, whose trade-off can ultimately impact population dynamics albeit seldom empirically demonstrated. They can intricately affect survival rates, which are particularly relevant for species under exploitation. Using individual spatiotemporal information in Northwestern Mediterranean, we document for the first time the existence of a trade-off between condition and growth in regulating survival dynamics in two important fish species for the Mediterranean fisheries that are characterized by contrasting life histories. For the European hake (Merluccius merluccius), a benthopelagic species, juveniles' body condition was detected to be positively linked to survival and negatively associated with the growth of this age group. For the red mullet (Mullus barbatus), the same pattern was observed for young adults. We also show that the observed patterns on a regional level have a clear spatial dependence as we found that observed body condition over a local scale had a broad effect on the population dynamics of the whole region, with the Ebro delta area emerging as the demographic engine of the two species. We discuss our results in the context of fisheries management and underline the importance of improving current stock assessment models and spatially based fishery management towards incorporating body condition and growth due to their influence on important parameters such as survival.


Assuntos
Gadiformes , Perciformes , Animais , Mar Mediterrâneo , Peixes/fisiologia , Dinâmica Populacional , Pesqueiros
11.
Int. j. morphol ; 40(6): 1426-1433, dic. 2022. ilus, tab, graf
Artigo em Espanhol | LILACS | ID: biblio-1421800

RESUMO

La incorporación de estrategias de gamificación en la docencia se ha descrito como una herramienta para aumentar la motivación y el compromiso de los alumnos con la materia. Bajo esta premisa, se ha desarrollado una experiencia de innovación educativa mediante la plataforma Kahoot! en la primera y última práctica de laboratorio de la asignatura de Biología Celular del Grado en Biología. Los participantes fueron 135 alumnos repartidos en 12 grupos de laboratorio, que se dividieron entre experimentales y controles. Todos los grupos resolvieron un cuestionario en papel acerca de los conceptos explicados en clase, al finalizar ambas prácticas (post-test), pero sólo aquellos grupos experimentales resolvían un cuestionario antes de la clase (pre-test). Antes de la primera práctica, los alumnos de los grupos experimentales respondieron al pre-test mediante el Kahoot! Sin embargo, para la última práctica algunos grupos lo resolvieron jugando al Kahoot! y otros, con papel y bolígrafo. Los resultados mostraron que aquellos alumnos que fueron seleccionados para jugar a Kahoot!, obtuvieron un mayor número de aciertos en el test realizado tras la sesión práctica (post-test) con respecto a aquellos que no resolvieron ningún pre-test o, que lo hicieron de un modo clásico. Por lo tanto, nuestros resultados sugieren que implementar la jugabilidad en la docencia incrementa considerablemente la motivación del alumnado debido, probablemente, a cambios fisiológicos experimentados por el cerebro durante el juego y a la creación de un clima positivo, que facilitan el proceso de aprendizaje.


SUMMARY: The incorporation of gamification strategies in teaching has been described as a tool to increase the motivation and engagement of students with the subject. Under this premise, an educational innovation experience has been developed using the Kahoot! platform in the first and last laboratory practice of the Cell Biology course of the Biology degree. The participants were 135 students divided into 12 laboratory groups, which were divided into experimental and control groups. All groups solved a questionnaire on paper about the concepts explained in class, at the end of both practices (post-test), but only the experimental groups solved a questionnaire before the class (pre-test). Before the first practice, students in the experimental groups answered the pre-test using Kahoot! However, for the last practice, some groups solved it by playing Kahoot! and others with pen and paper. The results showed that those students who were selected to play Kahoot! obtained a higher number of correct answers in the test performed after the practical session (post-test) than those who did not solve any pre- test or who did it in a classical way. Therefore, our results suggest that implementing gamification in teaching considerably increases student motivation, probably due to physiological changes experienced by the brain during the game and the creation of a positive climate, which facilitates the learning process.


Assuntos
Humanos , Biologia Celular/educação , Gamificação , Aprendizagem , Motivação , Universidades
12.
Sci Rep ; 12(1): 9797, 2022 06 13.
Artigo em Inglês | MEDLINE | ID: mdl-35697727

RESUMO

An interesting evolutionary question that still remains open is the connectivity between marine populations. Marine currents can favour the dispersal of larvae or adults, but they can also produce eddies and gyres generating oceanographic fronts, thus limiting gene flow. To address this subject, we selected the Atlantic-Mediterranean transition, where several fronts are located: Gibraltar Strait (GS), Almeria-Oran Front (AOF) and Ibiza Channel (IC). Seven populations of the marine crab Liocarcinus depurator (Cadiz, West and East Alboran, Alacant, Valencia, Ebro Delta and North Catalonia) located along this transition were analysed in six consecutive years (2014-2019) using a fragment of the COI (Cytochrome Oxidase subunit I) gene. All sequences (966) belonged to two well defined haplogroups: ATL (most abundant in Atlantic waters) and MED (predominant in Mediterranean waters). Following a geographic variation, the frequency of ATL decreased significantly from Cadiz to North Catalonia. However, this variation presented steps due to the effect of oceanographic restrictions/fronts. Significant effects were recorded for GS (2015, 2017, 2018 and 2019), AOF (all years except 2018) and IC (2016). The intensity and precise location of these fronts changed over time. Multivariate analyses distinguished three main population groups: Cadiz, Alboran Sea and the remaining Mediterranean populations. These findings could be relevant to properly define Marine Protected Areas and for conservation and fisheries policies.


Assuntos
Braquiúros/fisiologia , Animais , Oceano Atlântico , Evolução Biológica , Braquiúros/genética , Conservação dos Recursos Naturais , Complexo IV da Cadeia de Transporte de Elétrons/genética , Política Ambiental , Pesqueiros/normas , Fluxo Gênico , Variação Genética , Humanos , Mar Mediterrâneo , Formulação de Políticas , Movimentos da Água
13.
Dalton Trans ; 51(4): 1325-1332, 2022 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-35018911

RESUMO

We describe here a comparative study between two tripodal anion receptors based on selenophene as the binding motif. The receptors use benzene or perfluorobenzene as a spacer. The presence of the electron-withdrawing ring activates the selenium atom for anion recognition inducing the formation of self-assembled supramolecular structures in the presence of chloride or bromide anions, which are bonded by the cooperative action of hydrogen and chalcogen bonding interactions. DOSY NMR and DLS experiments provided evidence for the formation of the supramolecular structures only in the presence of a perfluorobenzene based anion receptor while the analogous benzene one shows the classical anion/receptor complex without the participation of the selenium atom. The energetic and geometric features of the complexes of both receptors with the Cl and Br anions have been studied in solution. These results combined with the molecular electrostatic potential (MEP) surface plots allow us to rationalize the quite different behaviors of both receptors observed experimentally.

14.
Breast ; 61: 98-107, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34929424

RESUMO

AIM: BRCA1/2 mutation carriers with primary breast cancer (PBC) are at high risk of contralateral breast cancer (CBC). In a nationwide cohort, we investigated the effects of chemotherapeutic agents given for PBC on CBC risk separately in BRCA1 and BRCA2 mutation carriers. PATIENTS AND METHODS: BRCA1 or BRCA2 mutation carriers with an invasive PBC diagnosis from 1990 to 2017 were selected from a Dutch cohort. We estimated cumulative CBC incidence using competing risks analysis. Hazard ratios (HR) for the effect of neo-adjuvant or adjuvant chemotherapy and different chemotherapeutic agents on CBC risk were estimated using Cox regression. RESULTS: We included 1090 BRCA1 and 568 BRCA2 mutation carriers; median follow-up was 8.9 and 8.4 years, respectively. Ten-year cumulative CBC incidence for treatment with and without chemotherapy was 6.7% [95%CI: 5.1-8.6] and 16.7% [95%CI: 10.8-23.7] in BRCA1 and 4.8% [95%CI: 2.7-7.8] and 16.0% [95%CI: 9.3-24.4] in BRCA2 mutation carriers, respectively. Chemotherapy was associated with reduced CBC risk in BRCA1 (multivariable HR: 0.46, 95%CI: 0.29-0.74); a similar trend was observed in BRCA2 mutation carriers (HR: 0.63, 95%CI: 0.29-1.39). In BRCA1, risk reduction was most pronounced in the first 5 years (HR: 0.32, 95%CI: 0.17-0.61). Anthracyclines and the combination of anthracyclines with taxanes were associated with substantial CBC risk reduction in BRCA1 carriers (HR: 0.34, 95%CI: 0.17-0.68 and HR: 0.22, 95%CI: 0.08-0.62, respectively). CONCLUSION: Risk-reducing effects of chemotherapy are substantial for at least 5 years and may be used in personalised CBC risk prediction in any case for BRCA1 mutation carriers.


Assuntos
Neoplasias da Mama , Proteína BRCA1/genética , Proteína BRCA2/genética , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/genética , Quimioterapia Adjuvante , Estudos de Coortes , Feminino , Predisposição Genética para Doença , Heterozigoto , Humanos , Mutação , Fatores de Risco
15.
Index enferm ; 30(4)oct.-dic. 2021. tab
Artigo em Espanhol | IBECS | ID: ibc-222123

RESUMO

Objetivo principal: Analizar el grado de acuerdo en relación con una serie de mitos sobre violencia de género en personas jóvenes, y explorar factores asociados. Metodología: Estudio transversal mediante cuestionario voluntario y anónimo a jóvenes < 25 años residentes en Andalucía detectados por el alumnado de enfermería de la Universidad de Granada durante los años 2016 y 2018. Resultados principales: Participaron un total de 3291 jóvenes. Los mitos con mayor grado de acuerdo fueron: “Los maltratadores son violentos por naturaleza” (37%) y “Los maltratadores están locos” (36,3%). En 2018, respecto a 2016, se duplica el riesgo de estar de acuerdo con pensar que los maltratadores tienen problemas con el alcohol o drogas (OR=2,46; IC95%=2,02-3,00), la violencia de género ocurre en familias de bajo nivel económico o académico (OR=2,17; IC95%=1.54-3,04), o que son casos aislados (OR=2,02; IC95%=1.44-2.83). Conclusión principal: Persisten ciertos mitos entre la población juvenil andaluza, y además en los últimos años, algunos se han visto reforzados. (Au)


Objective: Analyze the degree of agreement in relation to a series of myths about gender violence in young people, and explore associated factors. Methods: Cross-sectional study using a voluntary and anonymous questionnaire to young people <25 years of age living in Andalusia detected by the Nursing students of the University of Granada during the years 2016 and 2018. Results: A total of 3,291 young people participated. The myths with the highest degree of agreement were: “Batterers are violent by nature” (37%) and “Batterers are crazy” (36.3%). In 2018, compared to 2016, the risk of agreeing with thinking that abusers have problems with alcohol or drugs is doubled (OR = 2.46; 95% CI = 2.02-3.00), gender violence occurs in families of low economic or academic level (OR = 2.17; 95% CI = 1.54-3.04), or that are isolated cases (OR = 2.02; 95% CI = 1.44-2.83). Conclusions: Certain myths persist among the Andalusian youth population, and also in recent years, some have been reinforced. (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto Jovem , Violência de Gênero , Estudantes de Enfermagem , Espanha , Estudos Transversais , Inquéritos e Questionários , Universidades
16.
Artigo em Inglês | MEDLINE | ID: mdl-34769642

RESUMO

(1) Background: Numerous educational interventions have been conducted to improve hand hygiene (HH) compliance and effectiveness among nursing students, with mixed results. The aim is to evaluate the effectiveness of posters as a teaching tool and factors associated with HH quality. (2) Methods: A pre-post experimental intervention study was conducted with a total of 293 nursing students randomly assigned to two groups (experimental and control) who, before and after HH, took cell culture samples from their non-dominant hands. Only the experimental group was exposed to the poster. (3) Results: In the experimental group, significant differences were observed among students older than 22 years (p = 0.017; V = 0.188), with a higher percentage of failures (15.7% vs. 3.6%). Poster displaying was associated with passing, other variables being equal, although without statistical significance (ORa = 2.07; 95% CI = 0.81-5.26). Pre-practice hand contamination was weakly associated with lower HH quality (ORa = 0.99, 95% CI = 0.99-0.99). (4) Conclusions: The use of posters as a teaching method shows indications of efficacy. Prior hand contamination slightly affects the quality of HH. Further evaluation of teaching methods is needed to ensure good technical performance of HH to prevent the spread of infectious diseases during the COVID-19 pandemic.


Assuntos
COVID-19 , Infecção Hospitalar , Higiene das Mãos , Estudos de Casos e Controles , Fidelidade a Diretrizes , Desinfecção das Mãos , Humanos , Pandemias , SARS-CoV-2 , Estudantes
17.
Artigo em Inglês | MEDLINE | ID: mdl-34071054

RESUMO

This study analysed the capacity of emergency physicians and nurses working in the city of Granada (Spain) to respond to intimate partner violence (IPV) against women, and the mediating role of certain factors and opinions towards certain sexist myths in the detection of cases. This is a cross-sectional study employing the physician readiness to manage intimate partner violence survey (PREMIS) between October 2020 and January 2021, with 164 surveys analysed. Descriptive and analytical statistics were applied, designing three multivariate regression models by considering opinions about different sexist myths. Odds ratios and 95% confidence intervals (CIs) were considered for the detection of cases. In the past six months, 34.8% of professionals reported that they had identified some cases of IPV, particularly physicians (OR = 2.47, 95% CI = 1.14-5.16; OR = 2.65, 95% CI = 1.26-5.56). Those who did not express opinions towards sexist myths related to the understanding of the victim or the consideration of alcohol/drug abuse as the main causes of violence and showed a greater probability of detecting a case (NS) (OR = 1.26 and OR = 1.65, respectively). In order to confirm the indicia found, further research is required, although there tends to be a common opinion towards the certain sexual myth of emergency department professionals not having an influence on IPV against women.


Assuntos
Violência por Parceiro Íntimo , Estudos Transversais , Atenção à Saúde , Serviço Hospitalar de Emergência , Feminino , Humanos , Espanha , Inquéritos e Questionários
18.
Artigo em Inglês | MEDLINE | ID: mdl-34065736

RESUMO

Dating violence is a significant problem among adolescents. It encompasses a variety of violent behavior, from verbal abuse to physical and sexual abuse, from threats to rape and murder. Among young people, idealization of love and romantic myths are very common as a consequence of our culture and society, which lead them to develop dysfunctional relationships that somehow favor and facilitate partner violence and sexist ideas in daily life. Education is the basic tool to eradicate discrimination and violence against women. The objective of this study is to explore the false myths of romantic love in adolescents and their related factors. A cross-sectional study was conducted with 16-19-year-old teenagers (n = 180), through questionnaires and by employing the romantic love myths scale, the ambivalent sexism inventory, and the love attitudes scale. Adolescents accepted to a greater degree the love myths associated with idealization than those related to abuse with scale values of Med = 2.72, SD = 0.55, and Med = 1.34, SD = 0.68, respectively. Designed models predict love idealization on the basis of benevolent sexism (ß = 0.03; CI 95% = 0.021-0.039), religion (ß = 0.198; CI 95% = 0.047-0.349), passionate love (ß = 0.038; CI 95% = 0.015-0.061), practical love (ß = 0.024; CI 95% = 0.001-0.047), and friendly love (ß = 0.036; CI 95% = 0.014-0.058). Hostile sexism and undergraduate studies were associated with the myths that relate love and abuse (ß = 0.19; CI 95% = 0.007-0.031, ß = 0.208; CI 95% = 0.001-0.414, respectively).


Assuntos
Violência por Parceiro Íntimo , Amor , Adolescente , Adulto , Agressão , Estudos Transversais , Feminino , Humanos , Violência , Adulto Jovem
19.
Artigo em Inglês | MEDLINE | ID: mdl-33805498

RESUMO

Scientific research is sometimes subjected to go through field study in places that are difficult to access. Where man has not managed to reach through traditional techniques, work at height systems offer new possibilities, provide safety in exploration and represent an excellent tool that allows a new insight of spaces object of scientific research. For more than 20 years, the Ukhupacha team has been studying, analyzing and selecting the teams, techniques and rope progression systems that best adapt to archaeological works in vertical environments. The projects studied are developed in Pre-Columbian cultures of the Andean mountain range, the high Amazon jungle and its surroundings. As a result, a new working methodology called Vertical Archaeology has been developed. It prioritizes user's safety by means of ropes when accessing archaeological research areas. The recommended and safest systems, techniques and personal protective equipment (PPE) are presented for each of the phases in which it is proposed to divide archaeological investigations: exploration, training and expedition. Using rope access techniques has allowed the safe study of new artistic and heritage aspects in ancient civilizations, as well as the approach of the scientific community to places that until now had remained hidden.


Assuntos
Arqueologia , Humanos , Masculino
20.
Chemosphere ; 274: 129770, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33549883

RESUMO

In the past decades, the intensity and duration of cyanobacterial blooms are increasing due to anthropogenic factors. These phenomena worry drinking water companies and water managers because cyanobacteria produce a diverse range of cyanotoxins, which can cause liver, digestive and neurological diseases. The main exposure routes for humans are the consumption of drinking water that has not been effectively treated and the recreational use of polluted waters. For risk assessment and to conduct studies on large-scale occurrence, the development of reliable but simple, sensitive and cost-effective analytical approaches able to cover a wide range of cyanotoxins is essential. Additionally, the determination of intracellular and extracellular toxins separately is advantageous for risk management. To the best of our knowledge, this is the first time that a method for the multi-class determination of cyanotoxins in fresh water, which is able to separately report intra- and extracellular toxins, meet the criteria of simplicity (not requiring multiple sample preparation procedures or time-consuming steps) and it is based on highly specific high resolution mass spectrometry (potential for wide screening and retrospective analysis). Matrix effects, trueness and precision met general validation criteria for a group of nine cyanotoxins, including anatoxins, cylindrospermopsin and microcystins. Considering a 50 mL sample, the method quantification limits were within the range of 8-45 ng L-1 and 25-129 ng L-1 for intra- and extracellular cyanotoxins, respectively. Anatoxin-a, cylindrospermopsin and some microcystins were found in three out of four Dutch lakes included in the study, at concentrations up to 52 µg L-1.


Assuntos
Cianobactérias , Microcistinas , Cromatografia Líquida de Alta Pressão , Água Doce , Humanos , Espectrometria de Massas , Microcistinas/análise , Estudos Retrospectivos
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