Internet Gaming Disorder and the Incidence of Suicide-Related Ideation and Behaviors in College Students.

OBJECTIVES: The longitudinal associations between DSM-5 Internet Gaming Disorder (IGD) and suicide-related ideation and behaviors have not been explored. In this study, we therefore seek to examine the association between baseline IGD and incident suicide ideation, plans, and attempts. METHODS: This is a prospective cohort study of 2586 Mexican college students followed up from September 2018 to June 2022. We estimated hazards ratios modeling incidence of suicide ideation, plans, and attempts by fitting proportional hazards Cox models with person-time scaled in years. RESULTS: Among 2140 students without suicide ideation at baseline, there were 467 incident cases in 3987.6 person-years; ideation incidence rates were 179 cases per 1000 person-years among students with IGD and 114 cases per 1000 person-years among those without IGD. Incidence rates for suicide plans were 67 and 39 per 1000 among IGD and non-IGD students, and 15 and 10 per 1000, respectively for attempts. After controlling for age, sex, and mood, anxiety, and substance use disorders, IGD was associated with an 83% increased risk of suicide ideation. Although incidence rate estimates for plans and attempts were higher among students with IGD, results were not statistically significant. CONCLUSIONS: This study helps to raise awareness of the increased risk of at least suicidal ideation in people experiencing IGD. Clinicians treating patients with IGD may encounter complaints of suicide ideation over time, and even reports of suicidal behavior that should not be disregarded. Identifying these patients and treating/referring them for underlying suicidality should form part of IGD treatment.

Ecotoxicological evaluation of chitosan biopolymer films particles in adult zebrafish (Danio rerio): A comparative study with polystyrene microplastics.

To mitigate the environmental impact of microplastics (MPs), the scientific community has innovated sustainable and biodegradable polymers as viable alternatives to traditional plastics. Chitosan, the deacetylated form of chitin, stands as one of the most thoroughly investigated biopolymers and has garnered significant interest due to its versatile applications in both medical and cosmetic fields. Nevertheless, there is still a knowledge gap regarding the impact that chitosan biopolymer films (CBPF) may generate in aquatic organisms. In light of the foregoing, this study aimed to assess and compare the potential effects of CBPF on the gastrointestinal tract, gills, brain, and liver of Danio rerio against those induced by MPs. The findings revealed that both CBPF and MPs induced changes in the levels of oxidative stress biomarkers across all organs. However, it is essential to note that our star plots illustrate a tendency for CBPF to activate antioxidant enzymes and for MPs to produce oxidative damage. Regarding gene expression, our findings indicate that MPs led to an up-regulation in the expression of genes associated with apoptotic response (p53, casp3, cas9, bax, and bcl2) in all fish organs. Meanwhile, CBPF produced the same effect in genes related to antioxidant response (nrf1 and nrf2). Overall, our histological observations substantiated these effects, revealing the presence of plastic particles and tissue alterations in the gills and gastrointestinal tract of fish subjected to MPs. From these results, it can be concluded that CBPF does not represent a risk to fish after long exposure.

Point of care thoracic ultrasound versus chest computed tomography in the approach of febrile neutropenia patients: A diagnostic accuracy cohort study.

Single-center prospective cohort diagnostic accuracy study. Our study aimed to evaluate the accuracy and reproducibility of Thoracic Ultrasound (TUS) in detecting pulmonary pathology in immunosuppressed patients. We conducted a single-center prospective study. Consecutive patients with febrile neutropenia who underwent CT (Computerized Tomography) underwent TUS evaluation within 24h of CT. Both studies were performed by an expert who was blinded to the clinical information and results of the alternative imaging modalities. 34 patients met the inclusion criteria. The median age was 39.9 years (±17 standard deviation). TUS as a diagnostic test had a sensitivity of 92.9% and specificity of 83.3%, negative predictive value of 71.4%, and positive predictive value of 96.3%. Substantial between-method agreement was demonstrated with a kappa of 0.71 (P = .001) between the TUS and chest CT findings. We obtained a kappa of 1 (P = .001) for the final diagnosis of Pleural Effusion (PE). We concluded that TUS is a promising screening test for immunocompromised individuals. The results showed good diagnostic performance of TUS compared to CT for the detection of pulmonary findings highly suggestive of pathology with high accuracy and reproducibility.

Estrés Percibido y Consumo de Alcohol en Indígenas / Perceived Stress and Alcohol Consumption in Indigenous

Introducción: En Latinoamérica el consumo de bebidas alcohólicas es causante de problemas relacionados con la salud física, mental y social. La Comisión Nacional para el Desarrollo de los Pueblos Indígenas señala que las poblaciones indígenas son vulnerables a presentar problemas con el consumo de alcohol derivado de algunas características como pobreza extrema y rezago educativo, nuestro objetivo fue conocer el efecto del estrés percibido sobre el consumo de alcohol en una población indígena. Material y método: El diseño del estudio fue descriptivo, correlacional, predictivo. Resultados: El estrés percibido se relacionó positiva y significativamente con el número de copas consumidas en un día típico (rs = .211, p‹.01), y con el consumo de alcohol AUDIT (rs= .328, p ‹ .01), sin embargo, se relacionó negativa y significativamente con la edad (rs = -.135, p ‹.05). El Modelo final presentó un efecto significativo en la totalidad del modelo (F (1,110) = 20.126, p = .001), explica el 39.3% de la varianza del consumo de alcohol. Se encontró que el estrés percibido tuvo un efecto positivo y significativo sobre el consumo de alcohol (B =.229, p ‹ .001). Conclusiones: El estrés percibido es un factor que influye en el consumo excesivo de alcohol en las poblaciones indígenas, se considera que el consumo de drogas es una estrategia de afrontamiento para hacer frente a problemas estresantes en la vida diaria. La población presento problemas con el consumo de alcohol excesivo episódico, prevalencias altas en consumo en el último año y consumo dañino (AU)

Introduction: In Latin America, alcoholic beverages consumption is a main reason of problems related to physical, mental and social health. The National Commission for the Development of Indigenous Peoples states that indigenous populations are vulnerable problems related to alcohol consumption because a set of characteristics such as extreme poverty and educational backwardness. Our objective was to determine the effect of perceived stress on alcohol consumption in an indigenous population.Method: Study design was descriptive, correlational, and predictive.Results: Perceived stress was positively and significantly related to the number of drinks consumed in a typical day (rs = .211, p‹.01), it’s also related with alcohol consumption (AUDIT) (rs= .328, p ‹ .01), however, it was negatively and significantly related to age (rs = -.135, p ‹.05). The final Model presented a significant effect in the whole model (F (1,110) = 20.126, p = .001), explaining 39.3% of the variance of alcohol consumption. Perceived stress was found to have a positive and significant effect on alcohol consumption (B =.229, p ‹ .001).Conclusions: Perceived stress is a factor influencing excessive alcohol consumption in indigenous populations, drug use is considered a coping strategy to deal with stressful problems in daily life. The population presented problems with heavy episodic drinking, past year drinking with high prevalence and harmful drinking (AU)

Traducción, adaptación cultural y validación de la Escala de Apoyo a Políticas Asociadas al Alcohol en universitarios mexicanos / Tradução, adaptação cultural e validação da Escala de Apoio a Políticas Associadas ao Álcool em universitários mexicanos / Translation, cultural adaptation, and validation of the Support for Public Policies to Reduce Alcohol-Related Problems Scale among Mexican university students

Resumen Marco contextual: La protección de la salud por medio de la prevención y la reducción del consumo de alcohol es una prioridad para la salud pública. Se han identificado algunas escalas para evaluar políticas públicas de alcohol, pero en idioma inglés. Objetivo: Evaluar las propiedades psicométricas de la traducción y adaptación cultural de una escala para evaluar el apoyo a políticas de alcohol en jóvenes universitarios mexicanos. Metodología: Estudio metodológico, con la participación de 367 estudiantes universitarios del sur de México. La validez del constructo se estimó mediante un análisis factorial exploratorio y se verificó la consistencia interna del cuestionario para comprobar su fiabilidad. Resultados: La consistencia interna fue de 0.96. La validez de constructo se realizó mediante el análisis factorial exploratorio y se identificó una estructura de tres factores: la reducción del daño, el mercadeo e información, y el precio y la disponibilidad. Conclusión: La escala mostró fiabilidad y validez adecuada, y puede ser aplicada en español como indicador empírico en estudios referentes a las políticas públicas de alcohol en jóvenes universitarios.

Abstract Background: Health protection through prevention and reduction of alcohol consumption is a public health priority. Some scales have been identified to assess public alcohol policies but in English language. Objective: To evaluate the psychometric properties of the translation and cultural adaptation of a scale to assess support for alcohol policies in young Mexican university students. Methodology: Methodological study, with the participation of 367 university students from southern Mexico. Construct validity was estimated by means of an exploratory factor analysis and the internal consistency of the questionnaire was checked to verify its reliability. Results: Internal consistency was 0.96. Construct validity was performed through exploratory factor analysis, identifying a three factors structure: harm reduction, marketing and information, and price and availability. Conclusion: The scale showed adequate reliability and validity, and can be applied in Spanish as an empirical indicator in studies concerning alcohol public policies in young university students.

Resumo Enquadramento: A proteção da saúde através da prevenção e redução do consumo de álcool é uma prioridade de saúde pública. Foram identificadas algumas escalas para avaliar as políticas públicas em matéria de álcool, mas em língua inglesa. Objetivo: Avaliar as propriedades psicométricas da tradução e adaptação cultural de uma escala para avaliar o apoio às políticas sobre o álcool em jovens estudantes universitários mexicanos. Metodologia: Estudo metodológico, com a participação de 367 estudantes universitários do sul do México. A validade do constructo foi estimada através de uma análise exploratória dos fatores e a consistência interna do questionário foi verificada para verificar a sua fiabilidade. Resultados: A consistência interna foi de 0,96. A validade de constructo foi realizada por médio de análise fatorial exploratória, identificando uma estrutura de três fatores: redução de danos, marketing e informação, e preço e disponibilidade. Conclusão: A escala mostrou fiabilidade e validade adequadas, e pode ser aplicada em espanhol como um indicador empírico em estudos relativos a políticas públicas sobre o álcool em jovens estudantes universitários.

Prevalence of African animal trypanosomiasis among livestock and domestic animals in Uganda: a systematic review and meta-regression analysis from 1980 to 2022.

African animal trypanosomiasis (AAT) is one of the major constraints to animal health and production in sub-Saharan Africa. To inform AAT control in Uganda and help advance along the progressive control pathway (PCP), we characterized AAT prevalence among eight host species in Uganda and explored factors that influence the prevalence variation between studies. We retrieved AAT prevalence publications (n = 2232) for Uganda (1980-2022) from five life sciences databases, focusing on studies specifying AAT detection methods, sample size, and the number of trypanosome-positive animals. Following PRISMA guidelines, we included 56 publications, and evaluated publication bias by the Luis Furuya-Kanamori (LFK) index. National AAT prevalence under DNA diagnostic methods for cattle, sheep and goats was 22.15%, 8.51% and 13.88%, respectively. Under DNA diagnostic methods, T. vivax was the most common Trypanosoma sp. in cattle (6.15%, 95% CI: 2.91-10.45) while T. brucei was most common among small ruminants (goats: 8.78%, 95% CI: 1.90-19.88, and sheep: 8.23%, 95% CI: 4.74-12.50, respectively). Northern and Eastern regions accounted for the highest AAT prevalence. Despite the limitations of this study (i.e., quality of reviewed studies, underrepresentation of districts/regions), we provide insights that could be used for better control of AAT in Uganda and identify knowledge gaps that need to be addressed to support the progressive control of AAT at country level and other regional endemic countries with similar AAT eco-epidemiology.

Amniotic fluid pulmonary embolism and COVID-19: Case report.

Amniotic fluid embolism is a rare complication of peripartum. It is caused by the entry of fetal components into the maternal systemic circulation. There are 2 main types: typical; it presents with the triad of hemodynamic collapse, respiratory distress and disseminated intravascular coagulation type coagulopathy, while atypical; disseminated intravascular coagulation does not occur. SARS CoV-2 infection causes coagulopathy due to the alteration of Virchow's triad and coagulation factors. We present the case of a 21-year-old pregnant woman who consulted for premature rupture of membranes, with an indication for cesarean section, and during surgery presented bradycardia, hypotension, and desaturation until cardiorespiratory arrest. An angiotomography showed amniotic fluid embolism associated with pulmonary edema, ruling out differential diagnoses associated with the disease, leaving as the only cause of the infection confirmed by COVID-19, which, it was inferred, was closely related to the immunological disorder suffered by the patient.

Manejo del paciente con Hipertiroidismo en consulta externa de la Unidad Técnica de Endocrinología del Hospital Carlos Andrade Marín / Management of the patient with hyperthyroidism in the outpatient clinic of the Technical Unit of Endocrinology of the Endocrinology Technical Unit of the Carlos Andrade Marín Hospital

El hipertiroidismo es un trastorno caracterizado por el exceso de hormonas tiroideas. El déficit de yodo es un factor clave en dicha patología y en lugares con suficiencia del mismo se asocian a au-toinmunidad tiroidea. La prevalencia de hipertiroidismo mani-fiesto varía del 0,2% al 1,3% en áreas con suficiencia de yodo, sin embargo, esto puede variar en cada país por diferencias en umbrales de diagnóstico, sensibilidad de ensayo y población se-leccionada. Un reporte de The Third National Health and Nutri-tion Examination Survey (NHANES III) mostró que el hiperti-roidismo manifiesto se presenta en 0,7% de la población general e hipertiroidismo subclínico en el 1,7%1,2.En incidencia, la patología se asocia con la suplementación de yodo, con la mayor frecuencia en áreas de deficiencias, por au-mento de nódulos tiroideos en la población anciana, teniendo a regiones de áreas montañosas como América del Sur, África Central y suroeste de Asia dentro de este grupo. Un meta aná-lisis de estudios europeos mostró una incidencia general de 50 casos por 100000 personas/años1. En Ecuador, según los datos del Instituto Nacional de Estadísticas y Censos (INEC) del 2017, se reportaron 157 casos de hipertiroidismo, de los cuales la En-fermedad de Graves (EG) fue la causa más común, seguida por el bocio multinodular tóxico (BMNT) y finalmente el adenoma tóxico (AT) con una incidencia de 61 %, 24 % y 14 % respecti-vamente3.Los pacientes con esta patología tienen aumento de riesgo com-plicaciones cardiovasculares y mortalidad por todas las causas, siendo falla cardíaca uno de sus principales desenlaces, así el diagnóstico precoz evita estos eventos, principalmente en pobla-ción de edad avanzada.El presente protocolo se ha realizado para un correcto trata-miento de esta patología en el Hospital de Especialidades Carlos Andrade Marín (HECAM).

Hyperthyroidism is a disorder characterized by an excess of thyroid hormones. Iodine deficiency is a key factor in this pa-thology and in places with iodine deficiency it is associated with thyroid autoimmunity. The prevalence of overt hyperthyroidism varies from 0,2% to 1,3% in iodine-sufficient areas; however, this may vary from country to country due to differences in diag-nostic thresholds, assay sensitivity, and selected population. A report from The Third National Health and Nutrition Examina-tion Survey (NHANES III) showed that overt hyperthyroidism occurs in 0,7% of the general population and subclinical hyper-thyroidism in 1,7%1,2.In incidence, the pathology is associated with iodine supplemen-tation, with the highest frequency in areas of deficiencies, due to increased thyroid nodules in the elderly population, having regions of mountainous areas such as South America, Central Africa and Southwest Asia within this group. A meta-analysis of European studies showed an overall incidence of 50 cases per 100000 person/years1. In Ecuador, according to data from the National Institute of Statistics and Census (INEC) in 2017, 157 cases of hyperthyroidism were reported, of which, Graves' di-sease (GD) was the most common cause, followed by toxic mul-tinodular goiter (BMNT) and finally toxic adenoma (TA) with an incidence of 61 %, 24 % and 14 % respectively3.Patients with this pathology have an increased risk of cardiovas-cular complications and all-cause mortality, with heart failure being one of the main outcomes, so early diagnosis avoids these events, mainly in the elderly population.The present protocol has been carried out for the correct treat-ment of this pathology at the Carlos Andrade Marín Specialties Hospital (HECAM).

Estilos de crianza parental y consumo de tabaco y alcohol en adolescentes y jóvenes escolarizados / Parenting styles and use of tobacco and alcohol in adolescents and young persons enrolled in school

Objetivo: describir la asociación de los estilos de crianza parental con el consumo de tabaco y alcohol en adolescentes y jóvenes del norte del estado de Nuevo León, México.Método: estudio descriptivo transversal. Población formada por estudiantes de 15 a 23 años de preparatoria y universitarios (N= 1.562) seleccionados por muestreo estratificado. Se midieron variables demográficas y de consumo de sustancias, así como el estilo de crianza percibido en padre y madre mediante la Escala de Steinberg (democrático, indulgente, autoritario, negligente). Se realizó estadística descriptiva y modelos de regresión lineal.Resultados: participaron 448 estudiantes. El 49,6% había consumido tabaco y el 76,6% alcohol alguna vez. Se encontraron diferencias estadísticamente significativas en el consumo de alcohol en función del estilo de crianza maternal, más frecuente en caso de estilo negligente (87%). A nivel multivariante, el estilo de crianza negligente del padre (β= 0,15) y mayor edad (β= 0,30) se asociaron a mayor cantidad de cigarros fumados en un día normal (R2= 0,08; p < 0,001). El estilo de crianza democrático de la madre (β= -0,16) y ser hombre (β= -0,25) explicaron una menor cantidad de copas consumidas en un día típico (R2= 0,08; p < 0,001).Conclusiones: la mitad de las personas participantes había consumido alguna vez tabaco y tres cuartas partes alcohol. Percibir al padre con estilo de crianza negligente aumentó la cantidad de tabaco consumido en un día típico. El estilo de crianza democrático de la madre se asoció a menor cantidad de alcohol consumido en un día típico.(AU)

Objective: to describe the association between parental styles and use of tobacco and alcohol in adolescents and young persons from the northern Nuevo León state, Mexico.Method: a descriptive cross-sectional study. The population was formed by 15-to-23-year-old high school and university students (N= 1.562) selected through stratified sampling. Demographic variables and use of substances were measured, as well as the parenting style perceived in their father and mother through the Steinberg Scale (democratic, indulgent, authoritative, neglectful). Descriptive statistics and linear regression models were conducted.Results: in total, 448 students participated in the study; 49.6% of them had smoked and 76.6% had used alcohol at some point. Statistically significant differences were found in the use of alcohol according to the parenting style by their mother, more frequent in the case of neglectful style (87%). At multivariate level, the neglectful parenting style by the father (β= 0.15) and older age (β= 0.30) were associated with a higher number of cigars smoked in a typical day (R2= 0.08; p < 0.001). The democratic parenting style by the mother (β= -0.16) and being male (β= -0.25) explained a lower number of drinks taken during a typical day (R2= 0.08; p < 0.001).Conclusions: half of the participants had smoked at some time, and three fourths of them had drank alcohol. Perceiving a neglectful parenting style in the father increased the amount of tobacco used in a typical day. The democratic parenting style of the mother was associated with a lower volume of alcohol taken in a typical day.(AU)

Influence of sucralose, acesulfame-k, and their mixture on brain's fish: A study of behavior, oxidative damage, and acetylcholinesterase activity in Daniorerio.

Sucralose (SUC) and acesulfame-k (ACE-K) are widely used artificial sweeteners worldwide; however, they are frequently detected in aquatic environments due to their low metabolism and inadequate removal during wastewater treatment. The harmful effects of these compounds on hydrobionts have yet to be fully understood, as data on their toxicity is limited and inconclusive. This research aimed to determine the impact of SUC (50, 75, 125 µg/L) and ACE-K (50, 75, 125 µg/L), individually and in combination, on fish's swimming behavior, acetylcholinesterase activity, and oxidative stress response after four months of exposure. Following exposure, adult Danio rerio displayed anxiety-like behavior, as evidenced by increased freezing time and decreased swimming activity. Additionally, analysis of fish brain tissue revealed a disruption of REDOX homeostasis, leading to oxidative stress, which may be responsible for the observed inhibition of AChE activity. The results indicated that ACE-K was more toxic than SUC, and the mixture of both compounds produced a more detrimental effect than when each compound was administered alone. These findings highlight the hazardous impacts of SUC and ACE-K on fish in environmentally relevant concentrations, suggesting that these compounds should be added to the priority pollutant list.

Inteligencia emocional, satisfacción laboral y consumo de alcohol en el personal de enfermería / Emotional intelligence, job satisfaction and alcohol consumption in nursing staff

Resumen Objetivo: Conocer la relación de la inteligencia emocional (IE), satisfacción laboral y consumo de alcohol en el personal de enfermería que labora en un hospital de tercer nivel de atención. Materiales y métodos: Estudio descriptivo, transversal y correlacional. La muestra fue de 129 profesionales de enfermería que laboran en un hospital de tercer nivel, divididos en áreas críticas y no críticas. Los instrumentos utilizados fueron una Cédula de Datos Socio-demográficos, Trait Meta Mood Scale (TMMS-24), Cuestionario de Satisfacción Laboral S10/12 y AUDIT. Resultados: El 75% fueron mujeres, con estudios de licenciatura, más del 45% consumieron alcohol en la última semana. Se encontró que existe una relación positiva y significativa entre la inteligencia emocional y la satisfacción laboral (rs = .236, p < .001), también se encontró relación negativa y ssignificativa entre la satisfacción laboral y el consumo de alcohol (rs = -.195, p < .05). Conclusiones: Se muestran diferencias entre la IE, la satisfacción laboral y el consumo de alcohol en el personal de enfermería de acuerdo con el área en la que labora. Así mismo se observa la relación positiva entre la IE y la satisfacción llaboral, además de relación negativa entre satisfacción laboral y consumo de alcohol. Este estudio manifiesta la importancia de conocer a profundidad que factores impactan el cuidado que proporciona el personal de enfermería dentro de los servicios hospitalarios y cuáles son los métodos que utilizan para afrontarlos.

Abstract Objective: To know the relationship between emotional intelligence, job satisfaction and alcohol consumption in nursing staff working in a tertiary care hospital. Materials and methods: Descriptive, cross-sectional, and correlational study. The sample consisted of 129 nursing professionals who work in a third level hospital, divided into critical and non-critical areas. The instruments used were a Socio-demographic Data Sheet, Trait Meta Mood Scale (TMMS-24), Job Satisfaction Questionnaire S10/12 and AUDIT. Results: 75% were women, with undergraduate studies, more than 45% consumed in the last week. It was found that there is a positive and significant relationship between emotional intelligence and job satisfaction (rs = .236, p < .001), a negative and significant relationship was also found between job satisfaction and alcohol consumption (rs = -.195, p < .05). Conclusions: Differences are shown between EI, job satisfaction and alcohol consumption in nursing staff according to the area in which they work. Likewise, there is a positive relationship between EI and job satisfaction and a negative relationship between job satisfaction and alcohol consumption. This study demonstrates the importance of knowing in depth what factors impact the care provided by nursing staff within hospital services and what are the methods used to deal with them.

Depression, suicide ideation, and irrational beliefs: Explanatory models in psychology students / Depresión, ideación suicida y creencias irracionales: modelos explicativos en estudiantes de psicología

Abstract Introduction In rational emotive behavioral therapy, irrational beliefs are significant in mental health since their presence leads to conditions such as depression and suicidal ideation. Since these conditions have been increasing worldwide, it is essential to explore the factors that contribute to their understanding. Objective To design explanatory models for depression and suicidal ideation based on irrational beliefs in psychology students. Method Quantitative, non-experimental, cross-sectional study with multivariate analysis. Results Two explanatory models were designed: one for depression and the other for suicidal ideation. Thirty-nine per cent of depressive symptomatology can be explained by the presence of irrational beliefs concerning perfectionism, avoidance of responsibilities, concern over the future, and the determinism of the past. At the same time, 54% of suicidal ideation can be explained by the presence of beliefs centering on perfectionism, avoidance of responsibilities, external locus of control, and the determinism of the past. Discussion and conclusion Depression and suicidal ideation in psychology students can partly be explained by irrational beliefs concerning perfectionism, external locus of control, concern over the future, avoidance of responsibilities, and the determinism of the past. Clinical care approaches can modify these beliefs to reduce symptoms and promote mental health.

Resumen Introducción Para la terapia racional emotiva conductual las creencias irracionales tienen un gran peso en la salud mental, ya que la presencia de estas genera padecimientos como depresión e ideación suicida. Se sabe que en el mundo estos padecimientos han ido en aumento, por ello, es importante explorar factores que faciliten su explicación. Objetivo Generar modelos explicativos para la depresión y la ideación suicida desde las creencias irracionales en estudiantes de psicología. Método Estudio cuantitativo, no experimental, transversal con análisis multivariado. Resultados Se realizaron modelos explicativos; uno para la depresión y otro para ideación suicida. La sintomatología depresiva se explica en 39% con la presencia de creencias irracionales de perfeccionismo, evitación de responsabilidades, preocupación por el futuro y determinismo del pasado. Por otro lado, la ideación suicida se explica en 54% con la presencia de las creencias de perfeccionismo, evitación de responsabilidades, locus de control externo y determinismo del pasado. Discusión y conclusión La depresión e ideación suicida en estudiantes de psicología se puede explicar en parte por creencias irracionales de perfeccionismo, locus de control externo, preocupación por el futuro, evitación de responsabilidades y determinismo del pasado. A través de enfoques de atención clínica es factible modificar dichas creencias con el objetivo de disminuir sintomatología y promover la salud mental.

Adeno-associated virus type 2 in US children with acute severe hepatitis.

As of August 2022, clusters of acute severe hepatitis of unknown aetiology in children have been reported from 35 countries, including the USA1,2. Previous studies have found human adenoviruses (HAdVs) in the blood from patients in Europe and the USA3-7, although it is unclear whether this virus is causative. Here we used PCR testing, viral enrichment-based sequencing and agnostic metagenomic sequencing to analyse samples from 16 HAdV-positive cases from 1 October 2021 to 22 May 2022, in parallel with 113 controls. In blood from 14 cases, adeno-associated virus type 2 (AAV2) sequences were detected in 93% (13 of 14), compared to 4 (3.5%) of 113 controls (P < 0.001) and to 0 of 30 patients with hepatitis of defined aetiology (P < 0.001). In controls, HAdV type 41 was detected in blood from 9 (39.1%) of the 23 patients with acute gastroenteritis (without hepatitis), including 8 of 9 patients with positive stool HAdV testing, but co-infection with AAV2 was observed in only 3 (13.0%) of these 23 patients versus 93% of cases (P < 0.001). Co-infections by Epstein-Barr virus, human herpesvirus 6 and/or enterovirus A71 were also detected in 12 (85.7%) of 14 cases, with higher herpesvirus detection in cases versus controls (P < 0.001). Our findings suggest that the severity of the disease is related to co-infections involving AAV2 and one or more helper viruses.

Management of Nail Disease in Patients With Psoriatic Arthritis: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations.

OBJECTIVE: Nail psoriasis is common, impairs fine motor finger functioning, affects cosmesis, and is associated with a lower quality of life. This review updates the previous Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations for nail psoriasis. METHODS: This systematic literature review of the PubMed, MEDLINE, Embase, and Cochrane databases examined the updated evidence since the last GRAPPA nail psoriasis treatment recommendations published in 2014. Recommendations are based on preformed PICO (Patient/Population - Intervention - Comparison/Comparator - Outcome) questions formulated by an international group of dermatologists, rheumatologists, and patient panel members. Data from this literature review were evaluated in line with Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. RESULTS: Overall, there is insufficient evidence to make any recommendation for the use of topical corticosteroids, topical calcipotriol, topical tazarotene, topical cyclosporine, dimethyl fumarates/fumaric acid esters, phototherapy, and alitretinoin. There is a low strength of evidence to support the use of calcipotriol and corticosteroid preparations, topical tacrolimus, oral cyclosporine, oral methotrexate, intralesional corticosteroids, pulsed dye laser, acitretin, Janus kinase inhibitors, and apremilast. CONCLUSION: The highest strength of supporting evidence is for the recommendation of biologic agents including tumor necrosis factor inhibitors, and interleukin 12/23, 17, and 23 inhibitors.

Inteligencia emocional como mediador del craving y el riesgo de recaída en adultos en tratamiento por consumo de alcohol

Objetivos: Analizar el efecto de craving sobre el riesgo de recaída en adultos en tratamiento por alcohol, considerando la Inteligencia Emocional Percibida (IEP) como mediador. Materiales y métodos: Estudio descriptivo, transversal, predictivo, de comprobación de modelo con análisis de mediación. La muestra fue de 274 adultos internos en Centros de Rehabilitación contra las Adicciones (CRCA). Los instrumentos utilizados fueron una Cédula de Datos Sociodemográficos, Cuestionario de Craving por Alcohol, Inventario de Cociente Emocional y Cuestionario de Variables Predictoras de Abandono y Adhesión al Tratamiento. Resultados: Existe una relación inversa entre la IEP, el riesgo de recaída (r = -,381, p <,001) y el craving (r = -,354, p <,001). El craving y el riesgo de recaída se relacionaron positivamente (r = ,218, p <,001). Se reporta un efecto total significativo del craving sobre el riesgo de recaída cuando es mediado por la IE, el cual explica el 11 % de la varianza (B = ,1389; t = 5,688; p <,001). Conclusiones: Los resultados de este estudio indican que IEP se asocia inversamente con el craving y el riesgo de recaída, además de que la IEP desempeña un papel significativo como mediador en esta relación. Esto sugiere que las personas con altos niveles de IEP disponen de más recursos para gestionar sus emociones, lo que podría ayudar a reducir las conductas de craving y, consecuentemente, sufrir un menor riesgo de recaída en el consumo de alcohol.

Objectives: To analyze the effect of craving on the risk of relapse in adults undergoing alcohol treatment, considering the Perceived Emotional Intelligence (PEI) as a mediator. Materials and methods: Descriptive, cross-sectional, predictive study, model checking with mediation analysis. The sample consisted of 274 adults interned in Rehabilitation Centers against Addictions (CRCA). The instruments used were a Sociodemographic Data Card, Alcohol Craving Questionnaire, Emotional Quotient Inventory and Questionnaire of Variables Predictors of Abandonment and Adherence to Treatment. Results: There is an inverse relationship between PEI, the risk of relapse (r = -, 381, p <,001) and craving (r = -, 354, p <,001). Craving and risk of relapse were positively related (r = ,218, p <,001). A significant total effect of craving on the risk of relapse is reported when mediated by EI, which explains 11% of the variance (B = ,1389; t = 5,688; p <,001). Conclusions: The results of this study indicate that PEI is inversely associated with craving and risk of relapse, and that PEI plays a significant role as a mediator in this relationship. This suggests the notion that people with high PEI levels have more resources to manage their emotions, which could help reduce craving behaviors and consequently, suffer a lower risk of relapse into alcohol consumption.

Perceived discrimination and alcohol consumption in an indigenous population / Discriminación percibida y consumo de alcohol en una población indígena

Abstract Introduction Indigenous populations are considered a vulnerable minority and have characteristics such as poverty, difficulties to access food, housing, and educational backwardness; these conditions make them prone to alcohol consumption problems. Dependence on alcohol consumption probably arises as a symbol of protest, challenge, and response to social anguish, which has in turn repercussions in marginal population sectors that have conditions of fragility due to exploitation and discrimination, such as indigenous people. Objective To know the effect of perceived discrimination on alcohol consumption in Mexican indigenous population. Method Research design was descriptive, correlational check-model, with a sample of 362 adults from two indigenous communities. Results A simple linear regression model was performed, which shows a significant effect in the entire model (F[248] = 78.312, p = .001), which explains 49% of the variance of alcohol consumption. A significant positive influence was also found from the perceived discrimination variable (β = .626, p < .001) on alcohol consumption. Discussion and conclusion The studied indigenous communities had characteristics that the literature highlights as risk factors for developing addictive behaviors of alcohol consumption. These results coincide with those of the National Commission for the Development of Indigenous Peoples. Indigenous population present discrimination problems that are associated with alcohol consumption problems.

Resumen Introducción Las poblaciones indígenas se consideran minoritarias y vulnerables, y se caracterizan por su pobreza, dificultad para acceder a la alimentación, la vivienda y el rezago educativo. Estas condiciones los vuelven propensos a presentar problemas de consumo de alcohol. La dependencia al consumo de alcohol surge probablemente como símbolo de protesta, reto y respuesta a la angustia social, lo cual repercute en los sectores poblacionales marginales que poseen condiciones de fragilidad por la explotación y discriminación como los pueblos indígenas. Objetivo Conocer el efecto de la discriminación percibida en el consumo de alcohol en poblaciones indígenas mexicanas. Método El diseño del estudio fue descriptivo, correlacional de comprobación de modelo, con una muestra de 362 adultos de dos comunidades indígenas. Resultados Se realizó el modelo de regresión lineal simple el cual muestra efecto significativo en la totalidad del modelo (F[248] = 78.312, p = .001), explica el 49% de la varianza del consumo de alcohol, además se encontró influencia positiva significativa de la variable discriminación percibida (β = .626, p < .001) sobre el consumo de alcohol. Discusión y conclusión Las comunidades indígenas estudiadas poseen características que la literatura destaca como factores de riesgo para desarrollar conductas adictivas de consumo de alcohol, estos resultados coinciden con lo expuesto por la Comisión Nacional para el Desarrollo de los Pueblos Indígenas. Las poblaciones indígenas presentan problemas de discriminación que se asocian con los problemas de consumo de alcohol.

Síndrome de quilomicronemia familiar: primer caso reportado en Ecuador / Familial chylomicronemia syndrome: The first case reported in Ecuador

El síndrome de quilomicronemia familiar (SQF) es una entidad genética de herencia autosómica recesiva. Las mutaciones en genes (como APOC2, APOAV, LMF-1, GPIHBP-1) que codifican para proteínas que regulan la maduración, transporte o polimerización de lipoproteína lipasa-1 son las causas más comunes, pero no las únicas. El objetivo de este estudio fue reportar el primer caso documentado en el Ecuador.Caso clínico: hombre de 38 años que presentó hepatoesplenomegalia crónica, trombocitopenia, atrofia pancreática e hipertrigliceridemia severa refractaria al tratamiento. Se realizó un análisis molecular por secuenciación de nueva generación que determinó una deficiencia de lipoproteína lipasa OMIM #238600 en homocigosis. La confirmación genética es necesaria a fin de poder establecer la etiología de HTGS para un adecuado manejo de esta patología.(AU)

Familial chylomicronemia syndrome (FCS) is a genetic entity with autosomal recessive inheritance. Mutations in genes (such as APOC2, APOAV, LMF-1, GPIHBP-1) that code for proteins that regulate the maturation, transport, or polymerization of lipoprotein lipase-1 are the most common causes, but not the only ones. The objective of this study was to report the first documented case in Ecuador.Clinical caseA 38-year-old man presented with chronic hepatosplenomegaly, thrombocytopenia, pancreatic atrophy, and severe hypertriglyceridemia refractory to treatment. A molecular analysis was performed by next generation sequencing that determined a deficiency of Lipoprotein Lipase OMIM #238600 in homozygosis. Genetic confirmation is necessary in order to establish the etiology of HTGS for an adequate management of this pathology.(AU)

Condiciones comunitarias y el consumo problemático de marihuana en adultos jóvenes / Community conditions and the troublesome use of cannabis in young adults

Objetivo: analizar la influencia de las condiciones comunitarias (exposición a la oportunidad de consumo y entorno del barrio) sobre el consumo problemático y reciente de marihuana en adultos jóvenes de una zona rural del norte de Nuevo León, México.Métodos: estudio analítico de casos y controles. Para confirmar el consumo reciente de marihuana se analizó una muestra de fluido oral. Además, se midieron variables sociodemográficas, se aplicó el cuestionario sobre Exposición a la Oportunidad de Consumo, la Escala de Características del Entorno del Barrioy la Prueba de Identificación de Problemas de Consumo deCannabis. Se realizaron modelos multivariantes de regresión logística.Resultados: en el 58,6% de los adultos jóvenes consumidores de marihuana se detectó un consumo reciente. Un 44,2% mostró un riesgo alto de consumo problemático de marihuana. En el modelo de regresión logística para el consumo problemático de marihuana, las variables que contribuyeron fueron la exposición a la oportunidad de consumo (OR= 1,15, IC95%: 1,10-1,21), estudiar (OR= 2,67; IC95%: 1,16-6,13) y trabajar (OR= 2,58; IC95%: 1,04-6,40). En el modelo para el consumo reciente se observó una influencia de la exposición a las oportunidades (OR= 1, 08; IC95%: 1,04-1,18) y el ser hombre (OR= 6,24; IC95%: 2,06-18,98).Conclusiones: la exposición a la oportunidad de consumo de marihuana y el dedicarse solo a estudiar o solo a trabajar fueron variables que influyeron positivamente con el consumo problemático de marihuana. Para el consumo reciente de marihuana influyeron positivamente la exposición a la oportunidad de marihuana y el ser hombre. No se mostró influencia del entorno del barrio con el consumo problemático y reciente de marihuana.(AU)

Objective: to analyse the influence of community conditions (exposure to chance of consumption and neighbourhood environment) on the recent and troublesome use of cannabis in young adults from a rural area of North Nuevo León, Mexico.Methods: an analytical case-control study. In order to confirm the recent use of cannabis, a sample of oral fluid was analysed. Sociodemographic variables were also measured, and the Exposure to Chance of Consumption questionnaire, the Neighbourhood Environment Characteristics Scale and the Test for Detection of Problems with Use of Cannabis were applied. Multivariate models of logistic regression were conducted.Results: recent use was detected in 58.6% of young adult users of cannabis; 44.2% presented high risk of troublesome consumption of cannabis. In the logistic regression model for the troublesome consumption of cannabis, the contributing variables were: exposure to chance of consumption (OR= 1.15, CI95%: 1.10-1.21), studying (OR= 2.67; CI95%: 1.16-6.13) and working (OR= 2.58; CI95%: 1.04-6.40). In the model for recent consumption, influence was observed by exposure to chances (OR= 1. 08; CI95%: 1.04-1.18) and being male (OR= 6.24; CI95%: 2.06-18.98).Conclusions: exposure to chance of cannabis consumption and sole dedication to studying or to working were variables with a positive influence on the troublesome use of cannabis. For recent use of cannabis, there was positive influence by exposure to chance of cannabis and being male. No influence by the neighbourhood environment was shown on troublesome and recent use of cannabis.(AU)

Familial chylomicronemia syndrome: The first case reported in Ecuador. / Síndrome de quilomicronemia familiar: primer caso reportado en Ecuador.

Familial chylomicronemia syndrome (FCS) is a genetic entity with autosomal recessive inheritance. Mutations in genes (such as APOC2, APOAV, LMF-1, GPIHBP-1) that code for proteins that regulate the maturation, transport, or polymerization of lipoprotein lipase-1 are the most common causes, but not the only ones. The objective of this study was to report the first documented case in Ecuador. CLINICAL CASE: A 38-year-old man presented with chronic hepatosplenomegaly, thrombocytopenia, pancreatic atrophy, and severe hypertriglyceridemia refractory to treatment. A molecular analysis was performed by next generation sequencing that determined a deficiency of Lipoprotein Lipase OMIM #238600 in homozygosis. Genetic confirmation is necessary in order to establish the etiology of HTGS for an adequate management of this pathology.

One-year incidence, predictors, and accuracy of prediction of suicidal thoughts and behaviors from the first to second year of university.

BACKGROUND: Research is scarce on the prospective predictors of first onset suicidal thoughts and behaviors (STB) and the accuracy of these predictors in university students, particularly in low-and-middle income countries. Therefore, we assessed the 1-year incidence of STB among first-year students, a broad range of prospective predictors of STB incidence, and evaluated the prediction accuracy of a baseline multivariate risk prediction model to identify students at highest risk for STB onset over the subsequent 12 months. METHODS: Students (n = 3238) from 13 universities in Mexico completed an online survey developed for the World Mental Health International College Student Surveys in their first year and again 12 months after. We ran generalized linear models and receiver operator curves. RESULTS: The 1-year incidence of suicidal ideation, plan and attempt was 8.53%, 3.75%, and 1.16%, respectively. Predictors in final models were female sex (ideation only), minority sexual orientation (ideation only), depression, eating disorders, ADHD (ideation and plan), ongoing arguments or breakup with a romantic partner (ideation only), emotional abuse (ideation only), parental death (ideation, plan), not Catholic/Christian (ideation, plan), not having someone to rely on, psychotic experiences (plan only), and insufficient sleep (attempt only). Prediction accuracy for ideation, plan and attempt was area under the curve = 0.76, 0.81 and 0.78, respectively. Targeting the top 10% of students at highest risk could reduce STB in the subsequent year up to 36%. CONCLUSIONS: By assessing these risk/protective factors in incoming students we identified students at greatest risk for developing STB to whom suicide prevention strategies could be targeted.