[Possible participation of the antidiuretic hormone in the inhibiting action of at on gastric secretion]. / O vozmozhnom uchastii antidiureticheskogo gormona v tormoziashchem deistvii zhira na zheludochnuiu sekretsiiu.

The experiments were performed on dogs with isolated pouches (according to Pavlov, Heidenhain and Gregory) to study the action of antidiuretic hormone (ADH) on gastric secretion produced by a food irritant (100 g of meat) and by administration of histamine and pentagastrin. ADH was shown to exert an inhibitory action on gastric secretion induced by food or humoral irritants in dogs with isolated pouches according to Pavlov and Heidenhain. In dogs with completely denervated isolated pouches, food irritant-induced gastric secretion was suppressed for 2 1/2--3 1/2 h. Then it exceeded the control level. During ADH administration the total acidity and the content of free hydrochloric acid noticeably decreased as compared to control. There was also a clear-cut tendency to a reduction in the concentration of common proteinases in gastric juice. Adrenoblockers abolished the inhibitor action of ADH on gastric secretion produced by food or humoral irritants, while the inhibitory action of fat was not reversed by phentolamine or obsidan. The data obtained indicate a different mechanism of the inhibitory effect of fat and ADH on gastric secretion.

[Effect of fats on gastric secretion in a varying degree of innervation of the isolated stomach]. / Vliianie nekotorykh zhirov na zheludochnuiu sekretsiiu pri razlichnoi stepeni innervatsii izolirovannogo zheludka.

On the ground of an investigation on dogs with different types of isolated stomachs a characteristics of peculiarities of the action on the gastric secretion by three dissimilar fats is given, viz. butter, sunflower and corn oils. The investigated fats differ considerably by the lengthy inhibition of the gastric secretion produced by meat, and to a still greater degree by the intensity of the 2nd phase of secretion (after inhibition). It is also shown that with a complete extramural denervation of the isolated stomach (after Gregory) the inhibitory action of fats remains to be strongly marked. However, in this case after the period of inhibition, in the 2nd phase a significantly reduced secretion of the gastric juice is observed.