Concordancia de dos métodos para el cálculo del riesgo cardiovascular: Framingham calibrado por REGICOR y SCORE / Concordance of two methdos for the calculation of cardiovascular risk: Framingham calibrated for REGICOR and SCORE

Introducción y objetivo. Las sociedades científicas proponen un abordaje integral de los factores de riesgo cardiovascular (RCV) para priorizar la prevención. En 2003 surgen dos nuevas propuestas para la valoración del RCV: la calibración de la ecuación de Framingham para España y la ecuación del proyecto SCORE. Analizamos el grado de acuerdo entre ambas mediciones. Material y método. Estudio descriptivo transversal. Pacientes incluidos en el programa Factores de Riesgo Cardiovascular en Atención Primaria. Se calcularon para el riesgo categorizado la ponderación cuadrática del índice kappa y el coeficiente de correlación intraclase, así como éste y la representación gráfica de Bland y Altman para riesgo absoluto. Resultados y discusión. Existe una buena concordancia entre ambos métodos teniendo en cuenta los distintos eventos finales medidos. Vemos más útil para la práctica clínica el uso de la ecuación de Framingham debido a la limitación del rango de edad que presenta SCORE

Introduction and objective. The scientific societies propose an integral approach of cardiovascular risk (CVR) factors to make prevention a priority. In 2003, two new proposals arose to assess CVR: calibration of the Framingham equation for Spain and the equation of the SCORE project. We analyze the degree of agreement between both measurements. Material and method. Cross-sectional descriptive study. Patients included in the program Cardiovascular Risk Factors in Primary Care. Quadratic weight of the kappa index and intraclass correlation coefficient and the latter and the graphic representation of Bland and Altman for absolute risk were calculated for categorized risk. Results and discussion. There is a good concordance between both methods, considering the different final events measured. We consider the use of the Framingham equation as more useful for the clinical practice due to the limitation of the age range which SCORE has

[Granulocyte-macrophage precursor cells in umbilical cord blood]. / Progenitores granulocito-macrofágicos en sangre de cordón umbilical.

Authors study growth patterns of granulocytic-macrophagic progenitors in umbilical cord blood of 21 full-term newborns, using collagen gel culture method. Predominantly they obtain pure macrophagic colonies or mixed granulocytic colonies. After 7 days of incubation mean and SD of clusters in 103.22 +/- 75.88, and mean and SD of colonies is 34.26 +/- 23.1. After 14 days clusters falls down until 47.2 +/- 30.48, but colonies goes up to 74.2 +/- 32.78. Lineal regression analysis shows a correlation coefficient of 0.809 between 7 days and 14 days colonies. These results demonstrate the different behaviour between myelopoietic progenitor from umbilical cord blood and same progenitor from adult blood and are probably related to different nature of both progenitors.