[Pharmacologic suppression of the ovarian function and its clinical usefulness]. / Supresión farmacológica de la función ovárica y su utilidad clínica.

The gonadotropin-releasing hormone (GnRH) is essential in human reproduction. By modification of the molecular structure of the original hormone, analogues were synthesized with agonistic or antagonistic effects. GnRH agonists have high binding affinity for receptors, and their prolonged or continuous use resulted in inhibition of LH and FSH release. On the other hand, GnRH antagonists have an entirely different mechanism of action but still suppress gonadotrophin release. Currently, the use of analogues of GnRH is an established therapy for hormone-dependent diseases and other clinical conditions.

[Peri-conception use of folic acid in the prevention of neural tube defect: current concepts]. / Uso periconcepcional de ácido fólico en la prevención de defectos del tubo neural: conceptos actuales.

The incidence of neural tube defects (NTDs) is about 1.3 cases per 1000 live births. The higher incidence of NTDs occurs among certain ethnic groups, and geographic areas. The fetal morbimortality is high and the treatment for those babies who live is expensive with pour quality of live. It is unclear what biochemical mechanism involving folate explain the relationship of this vitamin to the pathogenesis of NTDs. However elevated concentrations of homocysteine or decreased methionine concentrations could be interfere with closure of the neural tube. The pharmacologic periconceptional intake of 0.4-4.0 mg/day of folic acid reduces the risk of occurrent NTDs by approximately 40-75%. A relatively high dietary intake of folate may also reduce the risk.

[Effect of prepuberal gonadectomy in partial androgen resistance syndrome]. / Efecto de la gonadectomía prepuberal en el Síndrome de Resistencia Parcial a los Andrógenos.

The androgen resistance syndrome, is a dominant and recessive linked to X disorder, with clinically heterogenous manifestations. Reported case. A 17-years patient with primary amenorrhoea and genital ambiguity. Bilateral inguinal herniplastia and probable gonadectomy were performed at 14-months-old. His cariotipe was male 46,XY and the hormonal determinations showed the presence of hypergonadotropic hypogonadismo. The congenital adrenal hyperplasia (deficiency of 21-hidroxilase) was discarded. In the partial androgen resistance syndrome, the prepuberal gonadectomy avoid a progresive virilization of the external genitals. However, the estrogenic hormonal replacement is mandatory.