RESUMO
We analysed the impact of the Xpert(®) MTB/RIF molecular test on health-care diagnostic delay among tuberculosis patients. Diagnostic delay was 17.2 days (standard deviation 23.2, median 10 days). Of 128 patients recruited into the study, 60 (47%) were smear-negative; of these, 40 (67%) were Xpert-positive and were started on treatment without culture. The sensitivity of smear microscopy was 53% compared with 82% for Xpert. In smear-negative patients, delay in Xpert-positive and -negative patients was respectively 15.5 ± 13.2 and 25.5 ± 12.5 days (P = 0.002). We conclude that Xpert results were significantly associated with shorter health-care diagnostic delay, particularly in smear-negative patients.
Assuntos
Técnicas Bacteriológicas , DNA Bacteriano/genética , Técnicas de Diagnóstico Molecular , Mycobacterium tuberculosis/genética , Tuberculose Pulmonar/diagnóstico , Adolescente , Adulto , DNA Bacteriano/isolamento & purificação , Diagnóstico Tardio , Feminino , Humanos , Masculino , Microscopia , Pessoa de Meia-Idade , Mycobacterium tuberculosis/isolamento & purificação , Valor Preditivo dos Testes , Estudos Retrospectivos , Escarro/microbiologia , Fatores de Tempo , Tuberculose Pulmonar/microbiologia , Adulto JovemRESUMO
Two cases of non-Hodgkin's endobronchial or bronchial-associated lymphoid tissue lymphoma are reported; such cases are either extremely rare or underestimated. We emphasize the need to perform endoscopic examination in patients with lymphoma and clinical findings that suggest bronchial disease.
