[The tuberculosis in 2020: challenges and opportunities.] / La tuberculosis en el año 2020: retos y oportunidades.

Despite the progress achieved in recent decades, tuberculosis continues to be a major public health problem in wide areas of the world geography, and caused more than 1.6 million deaths in 2017. The eruption of cases with multidrug-resistant tuberculosis and extremely resistant hinders its healing and its progressive eradication. Fortunately, in the past few years, molecular techniques capable of diagnosing the disease in a few hours have been introduced, also detecting genetic mutations that encode resistance to the most active drugs in its cure. With the incorporation of bedaquiline and delamanide, we count on new shorter, more effective and less toxic treatment schemes for resistant cases. The future of the fight against tuberculosis must be based on clinical suspicion in the most vulnerable groups (elderly, immunosuppressed and immigrants), an accurate and early diagnosis, a short treatment with oral drugs and the inclusion of solidarity socioeconomic strategies that improve the situation of the most vulnerable countries and groups.

A pesar de los avances obtenidos en las últimas décadas, la tuberculosis sigue siendo un importante problema de salud pública en amplias zonas de la geografía mundial, y produjo más de 1,6 millones de muertes en 2017. La irrupción de casos con tuberculosis multirresistente y extremadamente resistente dificulta su curación y su progresiva erradicación. Afortunadamente, en los últimos años se han introducido técnicas moleculares capaces de diagnosticar la enfermedad en pocas horas, detectando también mutaciones genéticas que codifican resistencias a los fármacos más activos en su curación. Con la incorporación de la bedaquilina y la delamanida contamos con nuevos esquemas de tratamiento más cortos y eficaces, así como menos tóxicos, para los casos resistentes. El futuro de la lucha contra la tuberculosis debe basarse en la sospecha clínica en los grupos más vulnerables (ancianos, inmunodeprimidos e inmigrantes), el diagnóstico preciso y precoz, el tratamiento corto con fármacos orales y la incorporación de estrategias socioeconómicas solidarias que mejoren la situación de los países y colectivos más vulnerables.

[Network against tuberculosis and for solidarity: the commitment of civil society]. / Red contra la Tuberculosis y por la Solidaridad: el compromiso de la sociedad civil.

Despite the progress made in the last years, the Tuberculosis remains a relevant public health problem in many geographic areas of the world. Tuberculosis is the paradigm of infectious disease with a high social component, and in its approach, measures aimed at reducing poverty, economic inequality and the integration of the most vulnerable groups cannot be ignored. Therefore, solidarity and social justice are terms associated with the control of this disease. The TBS Network, made up of various institutions born from civil society, tries to inform society and professionals about aspects of tuberculosis prevention, control, diagnosis, treatment and investigation, trying to avoid the stigma that still accompanies many patients. Among the activities organized by the TBS Network are, among others, the Solidarity Cinema Forum (in prisons, Red Cross premises and NGOs), Informa TB and Update Days.

A pesar de los avances obtenidos en los últimos años, la tuberculosis sigue siendo un problema relevante de salud pública en muchas zonas geográficas del mundo. La tuberculosis es el paradigma de enfermedad infecciosa con un alto componente social, y en su abordaje no pueden soslayarse las medidas tendentes a disminuir la pobreza, las desigualdades económicas y la integración de los colectivos más vulnerables. Por ello, la solidaridad y la justicia social son términos asociados al control de esta enfermedad. La Red TBS, integrada por diversas instituciones nacidas de la sociedad civil, intenta informar a la sociedad y a los profesionales sobre aspectos de prevención, control, diagnóstico, tratamiento e investigación de la tuberculosis, intentando evitar el estigma que acompaña todavía a muchos pacientes. Entre las actividades que organiza la Red TBS se encuentran, entre otras, el Cinefórum Solidario (en prisiones, locales de Cruz Roja y ONGs), Informa TB y Jornadas de Actualización.

Organización del control de la tuberculosis en España: evaluación de una estrategia dirigida a fomentar la acreditación de unidades de tuberculosis / Organization of Tuberculosis Control in Spain: Evaluation of a Strategy Aimed at Promoting the Accreditation of Tuberculosis Units

INTRODUCCIÓN: Un buen control de la tuberculosis (TB) requiere disponer de personal multidisciplinario bien coordinado. El objetivo fue evaluar el impacto de la acreditación de unidades de TB (UTB) fomentada por la Sociedad Española de Neumología (SEPAR) y ver las diferencias entre los centros que se acreditaron y los que no. MATERIAL Y MÉTODOS: DISEÑO: Estudio observacional descriptivo basado en una encuesta autoadministrada entre octubre de 2014 y febrero de 2018 a 139 responsables de neumología registrados por SEPAR, antes y después de la acreditación. VARIABLES: demográficas, epidemiológicas y sobre estudio de contactos, entre otras. Análisis: descriptiva básica, cálculo de medianas para variables continuas y proporciones para categóricas. Se compararon las variables mediante el test chi-cuadrado y regresión logística. RESULTADOS: La tasa de respuesta fue del 54,7 y del 43,2% en el período pre- y postacreditación de UTB, respectivamente. No se observaron cambios en los diferentes ámbitos de atención y coordinación entre la encuesta pre- y postacreditación, ni tampoco en la organización, al analizar los centros acreditados. Al comparar los centros que se acreditaron con los que no, se detectaron diferencias significativas con relación a recogida de conclusión final, manejo de resistencias, coordinación con otros servicios, estudios de contactos o tratamiento directamente observado. CONCLUSIONES: Se ha objetivado cómo abordan la TB diferentes profesionales, se han detectado aspectos positivos y otros mejorables, y se han observando indicadores de mejor funcionamiento en los centros que se acreditaron frente a los que no lo hicieron. Se precisa una supervisión cercana de las UTB para mejorar su efectividad

INTRODUCTION: Well-coordinated multidisciplinary teams are essential for better tuberculosis (TB) control. Our objective was to evaluate the impact of Spanish Society of Pneumology (SEPAR) accreditation of TB Units (TBU) and to determine differences between the accredited and non-accredited centers. MATERIAL AND METHODS: Design Observational descriptive study based on a self-administered survey from October 2014 to February 2018 completed by 139 heads of respiratory medicine departments collected by SEPAR, before and after TBU accreditation. VARIABLES: demographic, epidemiological and contact tracing (CT) variables, among others. Analysis: basic descriptive analysis, and calculation of medians for continuous variables and proportions for categorical variables. The variables were compared using the Chi-squared test and logistic regression. RESULTS: The response rate was 54.7% and 43.2% in the pre- and post-TBU accreditation period, respectively. No differences were observed in the care and coordination variables between the pre- and post-accreditation survey, nor in the organization when only accredited centers were analyzed. When we compared the accredited and non-accredited centers, significant differences were detected in the collection of the final conclusion, management of resistance, coordination with other departments, contact tracing, and directly observed treatment

Organization of Tuberculosis Control in Spain: Evaluation of a Strategy Aimed at Promoting the Accreditation of Tuberculosis Units. / Organización del control de la tuberculosis en España: evaluación de una estrategia dirigida a fomentar la acreditación de unidades de tuberculosis.

INTRODUCTION: Well-coordinated multidisciplinary teams are essential for better tuberculosis (TB) control. Our objective was to evaluate the impact of Spanish Society of Pneumology (SEPAR) accreditation of TB Units (TBU) and to determine differences between the accredited and non-accredited centers. DESIGN: Observational descriptive study based on a self-administered survey from October 2014 to February 2018 completed by 139 heads of respiratory medicine departments collected by SEPAR, before and after TBU accreditation. VARIABLES: demographic, epidemiological and contact tracing (CT) variables, among others. ANALYSIS: basic descriptive analysis, and calculation of medians for continuous variables and proportions for categorical variables. The variables were compared using the Chi-squared test and logistic regression. RESULTS: The response rate was 54.7% and 43.2% in the pre- and post-TBU accreditation period, respectively. No differences were observed in the care and coordination variables between the pre- and post-accreditation survey, nor in the organization when only accredited centers were analyzed. When we compared the accredited and non-accredited centers, significant differences were detected in the collection of the final conclusion, management of resistance, coordination with other departments, contact tracing, and directly observed treatment. CONCLUSIONS: The approach of different professionals with regard to TB has been addressed. Positive aspects and areas for improvement have been detected, and better results were observed in the accredited versus non-accredited centers. A closer supervision of TBUs is necessary to improve their effectiveness.

Red contra la Tuberculosis y por la Solidaridad: el compromiso de la sociedad civil / Network against Tuberculosis and for Solidarity: the commitment of civil society

A pesar de los avances obtenidos en los últimos años, la tuberculosis sigue siendo un problema relevante de salud pública en muchas zonas geográficas del mundo. La tuberculosis es el paradigma de enfermedad infecciosa con un alto componente social, y en su abordaje no pueden soslayarse las medidas tendentes a disminuir la pobreza, las desigualdades económicas y la integración de los colectivos más vulnerables. Por ello, la solidaridad y la justicia social son términos asociados al control de esta enfermedad. La Red TBS, integrada por diversas instituciones nacidas de la sociedad civil, intenta informar a la sociedad y a los profesionales sobre aspectos de prevención, control, diagnóstico, tratamiento e investigación de la tuberculosis, intentando evitar el estigma que acompaña todavía a muchos pacientes. Entre las actividades que organiza la Red TBS se encuentran, entre otras, el Cinefórum Solidario (en prisiones, locales de Cruz Roja y ONGs), Informa TB y Jornadas de Actualización

Despite the progress made in the last years, the Tuberculosis remains a relevant public health problem in many geographic areas of the world. Tuberculosis is the paradigm of infectious disease with a high social component, and in its approach, measures aimed at reducing poverty, economic inequality and the integration of the most vulnerable groups cannot be ignored. Therefore, solidarity and social justice are terms associated with the control of this disease. The TBS Network, made up of various institutions born from civil society, tries to inform society and professionals about aspects of tuberculosis prevention, control, diagnosis, treatment and investigation, trying to avoid the stigma that still accompanies many patients. Among the activities organized by the TBS Network are, among others, the Solidarity Cinema Forum (in prisons, Red Cross premises and NGOs), Informa TB and Update Days

La tuberculosis en el año 2020: retos y oportunidades / The tuberculosis in 2020: challenges and opportunities

A pesar de los avances obtenidos en las últimas décadas, la tuberculosis sigue siendo un importante problema de salud pública en amplias zonas de la geografía mundial, y produjo más de 1,6 millones de muertes en 2017. La irrupción de casos con tuberculosis multirresistente y extremadamente resistente dificulta su curación y su progresiva erradicación. Afortunadamente, en los últimos años se han introducido técnicas moleculares capaces de diagnosticar la enfermedad en pocas horas, detectando también mutaciones genéticas que codifican resistencias a los fármacos más activos en su curación. Con la incorporación de la bedaquilina y la delamanida contamos con nuevos esquemas de tratamiento más cortos y eficaces, así como menos tóxicos, para los casos resistentes. El futuro de la lucha contra la tuberculosis debe basarse en la sospecha clínica en los grupos más vulnerables (ancianos, inmunodeprimidos e inmigrantes), el diagnóstico preciso y precoz, el tratamiento corto con fármacos orales y la incorporación de estrategias socioeconómicas solidarias que mejoren la situación de los países y colectivos más vulnerables

Despite the progress achieved in recent decades, tuberculosis continues to be a major public health problem in wide areas of the world geography, and caused more than 1.6 million deaths in 2017. The eruption of cases with multidrug-resistant tuberculosis and extremely resistant hinders its healing and its progressive eradication. Fortunately, in the past few years, molecular techniques capable of diagnosing the disease in a few hours have been introduced, also detecting genetic mutations that encode resistance to the most active drugs in its cure. With the incorporation of bedaquiline and delamanide, we count on new shorter, more effective and less toxic treatment schemes for resistant cases. The future of the fight against tuberculosis must be based on clinical suspicion in the most vulnerable groups (elderly, immunosuppressed and immigrants), an accurate and early diagnosis, a short treatment with oral drugs and the inclusion of solidarity socioeconomic strategies that improve the situation of the most vulnerable countries and groups

Development of Aspergillosis in a cohort of non-neutropenic, non-transplant patients colonised by Aspergillus spp.

BACKGROUND: A previous study explored factors discriminating colonization and true infection among non-transplant, non-neutropenic patients with repeated Aspergillus spp. isolation from lower respiratory samples. The present study explored the evolution of patients with Aspergillus colonization in that study to determine the percentage of cases progressing to aspergillosis and time to development. METHODS: Clinical records were retrospectively reviewed (for each patient from his end date in the past study) and data from all respiratory processes suffered by patients up to April 2015 were recorded. Comparisons of variables were performed between colonized patients that developed aspergillosis and those that did not. A Kaplan-Meier curve was used to describe time to development of aspergillosis in chronic obstructive pulmonary disease (COPD) patients for II-IV stages of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification. RESULTS: Sixty seven colonized patients were followed, 12 of them (17.9%) developed aspergillosis. Diagnoses included six tracheobronchitis (4 invasive, 2 simple tracheobronchitis), four pulmonary disease (2 invasive pulmonary aspergillosis, 2 chronic pulmonary aspergillosis), one allergic bronchopulmonary aspergillosis and one pulmonary aspergilloma. Up to 47 (70.4%) of the study patients presented COPD. Among patients developing aspergillosis COPD was more frequent (100%) than among those that did not develop aspergillosis (35 out of 55; 63.6%) (p = 0.012), as well as GOLD IV patients were more frequent among COPD patients developing aspergillosis than among COPD patients that did not (50.0 vs. 26.1%, p = 0.046). Mean time to development of aspergillosis was 18.4 months (median: 8.5) with a wide range (1-58). Overtime, the percentage of patients developing aspergillosis was significantly higher among GOLD IV patients than among GOLD II-III patients (p = 0.032). CONCLUSIONS: The high percentage of cases progressing to aspergillosis among colonized patients, especially among those with COPD (25.5%), stresses the importance of colonization as risk factor, and creates awareness of the possible change from colonization to invasive disease in GOLD IV patients.

Repeated Aspergillus isolation in respiratory samples from non-immunocompromised patients not selected based on clinical diagnoses: colonisation or infection?

BACKGROUND: Isolation of Aspergillus from lower respiratory samples is associated with colonisation in high percentage of cases, making it of unclear significance. This study explored factors associated with diagnosis (infection vs. colonisation), treatment (administration or not of antifungals) and prognosis (mortality) in non-transplant/non-neutropenic patients showing repeated isolation of Aspergillus from lower respiratory samples. METHODS: Records of adult patients (29 Spanish hospitals) presenting ≥ 2 respiratory cultures yielding Aspergillus were retrospectively reviewed and categorised as proven (histopathological confirmation) or probable aspergillosis (new respiratory signs/symptoms with suggestive chest imaging) or colonisation (symptoms not attributable to Aspergillus without dyspnoea exacerbation, bronchospasm or new infiltrates). Logistic regression models (step-wise) were performed using Aspergillosis (probable + proven), antifungal treatment and mortality as dependent variables. Significant (p < 0.001) models showing the highest R2 were considered. RESULTS: A total of 245 patients were identified, 139 (56.7%) with Aspergillosis. Aspergillosis was associated (R2 = 0.291) with ICU admission (OR = 2.82), congestive heart failure (OR = 2.39) and steroids pre-admission (OR = 2.19) as well as with cavitations in X-ray/CT scan (OR = 10.68), radiological worsening (OR = 5.22) and COPD exacerbations/need for O2 interaction (OR = 3.52). Antifungals were administered to 79.1% patients with Aspergillosis (100% proven, 76.8% probable) and 29.2% colonised, with 69.5% patients receiving voriconazole alone or in combination. In colonised patients, administration of antifungals was associated with ICU admission at hospitalisation (OR = 12.38). In Aspergillosis patients its administration was positively associated (R(2) = 0.312) with bronchospasm (OR = 9.21) and days in ICU (OR = 1.82) and negatively with Gold III + IV (OR = 0.26), stroke (OR = 0.024) and quinolone treatment (OR = 0.29). Mortality was 78.6% in proven, 41.6% in probable and 12.3% in colonised patients, and was positively associated in Aspergillosis patients (R2 = 0.290) with radiological worsening (OR = 3.04), APACHE-II (OR = 1.09) and number of antibiotics for treatment (OR = 1.51) and negatively with species other than A. fumigatus (OR = 0.14) and aspergillar tracheobronchitis (OR = 0.27). CONCLUSIONS: Administration of antifungals was not always closely linked to the diagnostic categorisation (colonisation vs. Aspergillosis), being negatively associated with severe COPD (GOLD III + IV) and concomitant treatment with quinolones in patients with Aspergillosis, probably due to the similarity of signs/symptoms between this entity and pulmonary bacterial infections.

Clinical features of invasive pulmonary aspergillosis vs. colonization in COPD patients distributed by gold stage.

OBJECTIVE: To explore clinical features of invasive pulmonary aspergillosis (IPA) vs. colonization among hospitalized COPD patients. METHODS: Records of COPD patients with two respiratory cultures yielding Aspergillus were retrospectively reviewed. Cases categorized as proven/probable IPA or colonization was analyzed. RESULTS: 118 patients were identified: 70 (59.3%) colonized, 48 (40.7%) with IPA (42 probable, 6 proven). Higher percentage of IPA patients (vs. colonized) presented GOLD III + IV (77.1% vs. 57.1%, p = 0.025). IPA patients presented higher Charlson index (3.5 ± 2.5 vs. 2.6 ± 2.2, p = 0.027), higher rate of ICU admission (27.1% vs. 4.3%, p = 0.001) and worse prognosis (McCabe rapidly fatal category: 31.3% vs. 7.1%, p = 0.001). GOLD-I IPA patients presented risk factors other than COPD. Before hospitalization, 66.7% IPA and 28.6% colonized patients were taking steroids (p < 0.001). Antifungals were administered to 83.3% IPA and 21.4% colonized patients (p < 0.001). Mortality was higher among IPA vs. colonized patients, both in global (58.3% vs. 10.0%, p < 0.001), GOLD-I (75.0% vs. 10.0%, p = 0.041), GOLD-II (42.9% vs. 5.0%, p = 0.042) and GOLD-III patients (54.2% vs. 0.0%, p < 0.001), but not in GOLD-IV patients (69.2% vs. 31.3%, p = 0.066). CONCLUSIONS: IPA should be suspected not only in GOLD-III and GOLD-IV COPD patients, with higher mortality in IPA vs. colonized patients for GOLD-II and -III COPD patients.

Infección por Streptococcus pneumoniae, causa o consecuencia de proteinosis alveolar / Streptococcus pneumoniae infection: cause or consequence of pulmonary alveolar proteinosis?

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