RESUMO
Venous leg ulcers (VLU) represent an uphill economic, health and social burden, aggravated in the elderly. Best-practice care interventions are often insufficient and alternative therapies need to be explored. Herein, we have treated for the first time a chronic VLU in an elderly patient by combining cell therapy and tissue engineering in the context of a compassionate use. The administration of allogeneic adipose-derived mesenchymal stromal cells (MSCs) embedded in a plasma-based bioengineered dermis covering the ulcer bed and also injected into the ulcer margins led to the complete closure of a 10-year recalcitrant VLU in an 85-year-old patient. Regenerative properties of MSCs might be boosted by the use of bioengineered matrices for their delivery.
Assuntos
Úlcera da Perna , Células-Tronco Mesenquimais , Úlcera Varicosa , Tecido Adiposo , Idoso , Idoso de 80 Anos ou mais , Humanos , Úlcera da Perna/terapia , Engenharia TecidualRESUMO
Las lesiones del nervio femoral, en su mayor parte, son secundarias a iatrogenia tras intervenciones quirúrgicas. Presentamos un caso de lesión del nervio femoral tras extirpación de un tumor retroperitoneal, con una recuperación funcional aceptable después de reparar el defecto nervioso con injertos de nervio sural. El defecto tenía 10 cm y la recuperación obtenida MRC (Medical Research Council) fue de 4/5. Consideramos que en estos casos, la reparación precoz es fundamental para obtener un resultado adecuado, incluso en situaciones en la que se necesitan largos injertos nerviosos
Femoral nerve injuries are mostly secondary to iatrogenic after surgical interventions. We present a case of lesion of the femoral nerve after the removal of a retroperitoneal tumor, with an acceptable functional recovery after repair of the defect with sural nerve grafts. The defect was 10 cm length and the recovery obtained MRC (Medical Research Council) was 4/5. We considerer that early repair is essential to obtain an acceptable result, even in situations of being necessary long nerve grafts
