Mexican Multicenter Experience of Metastatic Spinal Disease.

Background Spinal metastatic disease is a silent progressive cancer complication with an increasing prevalence worldwide. The spine is the third most common site where solid tumors metastasize. Complications involved in spinal metastasis include root or spinal cord compression, progressing to a declining quality of life as patient autonomy reduces and pain increases. The main objective of this study is to report the incidence of patients and typology of spinal metastases in three reference centers in Mexico. Methodology Retrospective cohorts of patients diagnosed with spinal metastases from January 2010 to February 2017 at the National Cancer Institute, National Rehabilitation Institute, and the Traumatology and Orthopedics Hospital "Lomas Verdes" in Mexico City were analyzed. Results A total of 326 patients (56% males) with spinal metastases were reported. The mean age was 58.06 ± 14.05 years. The main sources of spinal metastases were tumors of unknown origin in 53 (16.25%) cases, breast cancer in 67 (20.5%) cases, prostate cancer in 59 (18%) cases, myeloma in 24 (7.4%) cases, and lung cancer in 23 (7.1%) cases. Conclusions The data obtained in this analysis delivers an updated standpoint on Mexico, providing the opportunity to distinguish the current data from global references. Collecting more epidemiological information for better recording of cancer and its associated complications, as well as further studies on them, is necessary.

Living arrangements and socioeconomic-based health disparities in Mexico.

OBJECTIVE: To investigate the role living arrangements play in the co-dynamics of socioeconomic position and health in the latter part of life. MATERIALS AND METHODS: Based on longitudinal data from the Mexican Health and Aging Study (MHAS), latent class analysis (LCA) and locally weighted regressions, in this article we estimate age trajectories to examine the degree to which wealth and health-related outcomes correlate with typical living arrangement dynamics. RESULTS: Main results suggest a complex dynamic relationship between living arrangements and social inequalities in health, with important differences by sex, unlike mortality trends as they appear to diverge with differences in wealth regardless of household structure. CONCLUSIONS: Our methodological approach provides new insights regarding the likely effect household structure plays when analyzing the dynamics of social inequality. To date, this is the first longitudinal analysis to offer this kind of empirical evidence for the region.

Single Dose of Tranexamic Acid Effectively Reduces Blood Loss in Patients Undergoing Spine Surgery: A Prospective Randomized Controlled Trial.

OBJECTIVE: To evaluate the efficacy of oral administration of tranexamic acid (TXA) in spine surgery to achieve blood loss reduction. METHODS: Sixty patients undergoing major surgery of the spine were randomly assigned into 2 groups. Group 1 was assigned as the control group and the other group comprised patients who received oral administration of TXA 2 hours before surgery. Outcome measures included intraoperative blood loss, postoperative blood loss, hematologic parameters, blood transfusion needed, and surgical complications. RESULTS: Sixty patients linked up with the inclusion criteria. Intraoperative blood loss was significantly lower in the TXA oral group than in the control group; total blood loss in the TXA group was 930.66 ± 614 mL, which was lower than in the control group, with 1075.66 ± 956.11 mL. The mean reduction of hemoglobin was almost the same in both groups. Similarly, the total transfusion package received was lower, and the number of complications and length of stay were akin in both groups. A logistic regression model was performed with patients who had blood loss >1000 mL and surgery time >230 minutes. This result was related to the risk of bleeding, with an odds ratio of 1.31, 95% confidence interval, 1.004-1.023, P = 0.004, independent of the group. CONCLUSIONS: Oral TXA is as an effective measure for reducing total blood loss among patients undergoing elective spine surgery.

Scientometric Analysis of Publications from 2004-2021 in the Spine Surgery Field: A Latin American Perspective.

OBJECTIVE: To determine characteristics of Latin American (LA) productivity in spine surgery published worldwide between 2004 and 2021 compared between periods and global literature. METHODS: A comprehensive search about LA productivity in the field of spine surgery using the Scopus and PubMed databases was performed in February 2022. The results were limited to articles published in indexed journals from 2004 to 2021. RESULTS: A total of 1447 publications were identified in the study period. The number of publications has increased across evaluated decades, with 583 between 2004 and 2013 (58.3/year) and 864 between 2014 and 2021 (108/year), and a yearly increase was demonstrated (P = 0.0001). Comparing the most productive year in the first (2012) and last decade (2020), a 1.79-fold increase was demonstrated. Brazil ranked first in productivity (51.14%), followed by Mexico (26.40%) and Argentina (8.64%). Coluna/Columna published the largest number, with 309 articles (21.35%). The top 10 institutions published at least 475 (32.82%) and the most productive was the University of Campinas (Brazil, 74). CONCLUSIONS: This scientometric study is one of the first regional evaluations worldwide. The number of publications in the spine surgery field in Latin America has continued to increase over evaluated decades from 58.3 per year to 108, and a 1.79-fold increase between the most productive years for each decade. Brazil is still the greatest contributor (51.14%), with Mexico (26.40%) and Argentina (8.64%) as growing contributor countries. Most publications were classified as Level of Evidence 4, and this result reflects the importance of continuous research development in the quality of research for our region.

Posterior Grade 4 Osteotomy With Vertebral Shortening Is Effective for the Treatment of Kyphosis Associated With Vertebral Discitis/Osteomyelitis.

BACKGROUND: In the retrospective study of a prospectively maintained database, we present a case series of patients with kyphotic deformity secondary to spinal infection treated using a posterior-only approach with 3-column shortening and posterior instrumentation. METHODS: This is a case series of patients presenting with postural deformity and sagittal imbalance treated consecutively by 1 surgeon between 2012 and 2014. Clinical assessments and radiographic evaluations were made preoperatively and at 12- and 24-month postoperative follow-ups. All patients underwent computed tomography 24 months after surgery to evaluate spinal fusion. RESULTS: The study included 5 patients with a mean age of 50 years (range, 32-60 years). Three patients had comorbidities. Three patients were classified as American Spinal Injury Association (ASIA) grade C and were not ambulatory; 2 were ASIA grade D. At follow-up, all patients were ambulatory and classified as ASIA grade E. Kyphosis was corrected from a preoperative mean of 32° (range, 15°-58°) to 10° (range, 1°-42°) at the 2-year follow-up. A mean improvement of 22° and 75% reduction in kyphosis was obtained with fixation 2 levels above and below the lesion. Interbody fusion was observed in all patients. No major complications occurred during surgery. CONCLUSIONS: Posterior grade 4 osteotomy with vertebral shortening can be performed safely in patients with kyphosis associated with vertebral discitis/osteomyelitis in the thoracolumbar region. The single approach allowed the surgeon to debride the infection, correct the kyphosis, decompress the spinal canal, and stabilize the spine. LEVEL OF EVIDENCE: 4.

Characteristics of Spinopelvic Sagittal Alignment in Lumbar Degenerative Disease.

BACKGROUND: Normal sagittal alignment shows a range of variations and normal values. This study compared sagittal vertebral alignment in patients with different degenerative lumbar diseases. METHODS: This cross-sectional study evaluated 300 patients who were enrolled between June 2016 and June 2017. Of these patients, 213 met the study criteria and were included. RESULTS: Of the 213 patients, 66 were men (31%) and 147 were women (68.2%). The mean age was 62.7 years. Diagnoses included degenerative spondylolisthesis in 116 patients (52.7%), lumbar disk degeneration in 76 patients (34.5%), lumbar spinal stenosis in 19 patients (8.6%), and lytic spondylolisthesis in 7 patients (3.2%). The most frequent Roussouly type of sagittal alignment was type 3 (33.6%), followed by type 4 (25.9%). No significant correlation was associated with Roussouly type of sagittal alignment and lumbar degenerative disease. Median sagittal vertebral alignment parameters in the series were as follows: pelvic incidence (PI), 60.55° ± 15.62°; sacral slope, 39.09° ± 12.48°; pelvic tilt, 20.92° ± 8.99°; lumbar lordosis, 33.15° ± 18.49°; and sagittal balance, 19.64 ± 55.27 mm. One hundred sixteen patients with degenerative spondylolisthesis had significant greater PI than those with other diagnoses (61.56° vs. 58.3°, respectively; P = 0.005), and patients with lumbar spinal stenosis had significantly lower PI than those with other diagnoses (55.89° vs. 60.44°, respectively; P = 0.005). CONCLUSIONS: Pelvic incidence may play a predisposing role in the pathogenesis of lumbar degenerative disease. Patients with degenerative spondylolisthesis have greater pelvic incidence with increased lumbar lordosis. In contrast, patients with spinal stenosis have lower pelvic incidence with flatter lumbar lordosis.

[Tratamiento quirúrgico de la escoliosis idiopática del adolescente. Resultados en el Instituto Nacional de Rehabilitación de México. Seguimiento mínimo de 24 meses]. / Idiopathic scoliosis's surgical treatment. Results in Mexico's National Rehabilitation Institute. 24 months follow.

ANTECEDENTES: La escoliosis idiopática del adolescente se define como una deformidad tridimensional de la columna vertebral que se presenta entre los 10 y los 18 años, y que se manifiesta con una curvatura vertebral en el plano coronal mayor de 10°. Esta deformidad afecta al 2-3% de la población general, pero solo el 10% del total requerirá en algún momento tratamiento quirúrgico. El método de elección para el manejo es el uso de tornillos transpediculares y barras desrotadoras. OBJETIVO: Realizar un análisis descriptivo de los pacientes que recibieron manejo quirúrgico en nuestro instituto con tornillos transpediculares y barras. MÉTODO: Se trata de un estudio observacional, retrospectivo, analítico, abierto, de muestreo no probabilístico, en el que se incluyeron los pacientes tratados con manejo quirúrgico entre 2012 y 2013. Las deformidades se estratificaron de acuerdo con la clasificación de Lenke. El ángulo de corrección de la deformidad, los niveles instrumentados, el sangrado transquirúrgico y la presencia de complicaciones fueron las variables analizadas. RESULTADOS: La mayoría de los pacientes presentaron curvas Lenke IBN, Nash Moe III, Cobb un promedio de 59.4° y cifosis de 47.8. En promedio se siguió a los pacientes por 35.84 meses, detectando un aumento de la curvatura coronal de 2.28° y un aumento de la curvatura sagital de 2.8°. CONCLUSIÓN: Al comparar estos resultados y la literatura mundial se concluyó que el tratamiento de la escoliosis idiopática del adolescente es un método seguro y reproducible que ofrece una mayor ventaja biomecánica y biológica sobre el uso de instrumentación mixta utilizada anteriormente. BACKGROUND: Adolescent's idiopathic scoliosis is defined as a three-dimensional deformity of the spine, which occurs between 10 and 18-year-old, has a spinal curvature >10° in the coronal plane. This deformity affects 2­3% of the general population, however, only 10% of the total will require surgery at some point. The method of choice for management is the use of pedicle screws and rods derotational. OBJECTIVE: To perform a descriptive analysis of patients who received surgical treatment in our institute with pedicle screws and rods. METHODS: This is an observational, retrospective, analytical, open study, non-probability sampling, in which patients requiring surgical treatment at our institute between 2012 and 2013 were included, the deformities were stratified according to the classification of Lenke. The angle of deformity correction, instrumented levels, amount of bleeding, presence of complications were the variables analyzed. RESULTS: Lenke classifying mostly IBN, Moe Nash III, an average of 59.4° Cobb and kyphosis of 47.8. On average it was followed patients for 35.84 months, detecting an increase 2.28° coronal curvature and sagittal curvature increase of 2.8°. CONCLUSION: Comparing these results and world literature concluded that the treatment of adolescent's idiopathic scoliosis is a safe and reproducible method that provides greater biomechanical and biological advantage over the use of mixed instrumentation used previously.

[Clinical presentation of a dorsal epidural arachnoid cyst after an epidural anesthesia]. / Presentación clínica de quiste aracnoideo epidural dorsal posterior a anestesia epidural.

BACKGROUND: Arachnoid cysts are dural diverticula with liquid content similar to cerebrospinal fluid, with 1% occurring in the spinal cord. They locate mainly in the dorsal region of the thoracic spine, and are unusual causes of spinal cord compression. CLINICAL CASE: The case is presented of a previously healthy 15-year-old boy, with a 20-month history of spastic paraparesis that started apparently after epidural block for ankle osteosynthesis. There was decreased sensitivity and strength of the pelvic limbs and gradually presented with anaesthesia from T12 to L4 dermatomes, L5 and S1 bilateral hypoaesthesia and 4+/5 bilateral strength, in the L2 root and 2+/5 in L3, L4, L5, S1, hyperreflexia, Babinski and clonus, but with no alteration in the sacral reflexes. In the magnetic resonance it was diagnosed as an extradural arachnoid cyst from T6 to T9. The patient underwent a T6 to T10 laminotomy, cyst resection, dural defect suture, and laminoplasty. One year after surgery, the patient had recovered sensitivity, improvement of muscle strength up to 4+/5 in L2 to S1, and normal reflexes. CONCLUSIONS: After the anaesthetic procedure, increased pressure and volume changes within the cyst could cause compression of the spinal cord, leading to symptoms. Despite being a long-term compression, the patient showed noticeable improvement.

[Spinal osteochondroma: diagnostic imaging and treatment. Case reports]. / Osteocondroma espinal: diagnóstico por imagen y tratamiento. Reporte de casos.

BACKGROUND: Osteochondromas are benign bony tumours, with only 1 to 4% being located in the spine. It occurs more frequently in the cervical spine, with C2 being the vertebra most affected. The neurological presentation is slow due to the growth characteristics of the tumour. Computed axial tomography is the reference method for diagnosis. Surgical management is indicated for patients with neurological impairment or pain. CLINICAL CASE: The first case presents a 21-year-old male with osteochondroma located in the spinous processes of L2, L3 and L4. The second case is a 20-year-old female with multiple osteochondromatosis with tumours at the right lateral mass of C1, with extension to C2 and tumours on the spinous processes of C5 and C7. Both patients presented with painful symptoms, which were resolved after surgical resection of the tumours. CONCLUSIONS: The rarity of these conditions, relevance of a clinical-radiographic diagnosis, and considerations required for surgical treatment are discussed here.