Abortion in goats by Caprine alphaherpesvirus 1 in Spain.

An abortion outbreak occurred in a goat herd of Murciano-Granadina breed in Almeria Region in Spain where 80 pregnant females aborted. All bacteriological and parasitological examinations resulted negative, whereas virological investigations and real-time PCR assay showed the presence of Caprine alphaherpesvirus 1 DNA in the pathological specimens from aborted foetuses. Nucleotide sequence analysis revealed that the DNA was highly close related to the Swiss strain E-CH (99.7%) and a little less extent to the Italian BA.1 strain (99.4%). Histopathological examination revealed multifocal, well-circumscribed, 50- to 200-µm-diameter foci of coagulative necrosis in the liver, lungs and kidneys of three foetuses. In the periphery of the necrosis, there were frequently epithelial cells with the chromatin emarginated by large, round, amphophilic intranuclear viral inclusion bodies. The source of the infection in the herd could not clearly find out even some hypothesis were formulated. This seems to be the first report of an abortion outbreak due to Caprine alphaherpesvirus 1 in a goat herd in Spain.

[Rhabdomyomatous mesenchymal hamartoma]. / Hamartoma mesenquimal rabdomiomatoso.

Rhabdomyomatous mesenchymal hamartoma is an extremely rare congenital lesion, and very few cases have been reported even though its macroscopic and microscopic features make diagnosis easy. An 18-year-old woman consulted with a pedunculated mass in the medial region of her neck. The mass was surgically removed, and rhabdomyomatous mesenchymal hamartoma was diagnosed. The clinical, macroscopic, histologic, and immunochemical characteristics that allow diagnosis of this entity are discussed. Although association with congenital abnormalities is uncommon, this possibility should be assessed by the clinician.

[Cryptococcoma in the central nervous system of a non-immunocompromised patient]. / Criptococoma en el sistema nervioso central de un paciente no inmunoafectado.

INTRODUCTION: Central nervous system cryptococcosis is an important cause of morbidity and mortality in immunocompromised patients; nevertheless, its presentation in immuno-spared patients is extremely rare, giving rise to a hole different spectrum, since it is manifested like granulomatous masses named cryptococomas. AIM. To describe an intracerebral case of cryptococcoma in an immuno-spared woman in the Hospital Universitario de Santander and to discuss the most relevant topics of this pathology. CASE REPORT: A 24 years-old woman, coming to the service presenting generalized tonic-clonic seizure, fixed upward gaze, sialorrhea and lost, without any data suggesting immunosupression. The computarized tomography of skull demonstrates a mass of possible inflammatory vs. noeplasmic origin. After performing imaging the patient is taken to surgery for craniotomy with excisional biopsy. By means of hystological analysis the diagnosis of cerebral criptococcoma is made, and antimycotic therapy is started, with favorable response. Actually the patient evidences good health, and no evidence of active disease. CONCLUSIONS: The presence of masses of criptococcal origin located at the central nervous system, which origin is due to a chronic granulomatous reaction, is rarely reported; these appear in almost all cases in immunocompetent patients, in which there is of primary importance to discard all causes of cellular immune deficit. Also, the diagnosis of these injuries must be considered before the presence of intracerebral masses that show inflammatory characteristics.

Criptococoma en el sistema nervioso central de un paciente no inmunoafectado / Cryptococcoma in the central nervous system of a non-immunocompromised patient

La criptococosis del sistema nervioso central (SNC) es una causa importante de morbilidad y mortalidaden pacientes inmunoafectados; sin embargo, su presentación en pacientes inmunocompetentes es extremadamente rara, ocasionando un espectro clínico diferente, ya que se manifiesta predominantemente como masas granulomatosas denominadascriptococomas. Objetivo. Describir un caso de criptococoma intracerebral en una mujer inmunocompetente atendida en el Hospital Universitario de Santander y discutir los aspectos más relevantes de esta patología. Caso clínico. Mujer de 24 años de edad, que ingresa por presentar convulsión tonicoclónica generalizada, con desviación de la mirada hacia arriba,sialorrea y pérdida de conocimiento, sin datos que sugieran inmunosupresión. La tomografía axial computarizada de cráneo evidencia una masa de posible origen inflamatorio en vez de neoplásico. Se lleva a cirugía y se le practica craneotomía conbiopsia excisional. Mediante análisis patológico, se hace el diagnóstico de criptococoma cerebral y se inicia el tratamiento antimicótico, con evolución favorable. Actualmente, la paciente se encuentra en buen estado de salud. Conclusiones. La presencia de masas de origen criptocóccico del SNC, debidas a una reacción granulomatosa crónica, se notifican raramente. Se presentan en casi todos los casos en pacientes inmunocompetentes, en los cuales es importante descartar todas las causas de afectación inmune celular. También el diagnóstico de estas lesiones debe tenerse en cuenta ante la presencia de masas intracranealesque muestren características inflamatorias

Central nervous system cryptococcosis is an important cause of morbidity and mortality in immunocompromisedpatients; nevertheless, its presentation in immuno-spared patients is extremely rare, giving rise to a holedifferent spectrum, since it is manifested like granulomatous masses named cryptococomas. Aim. To describe an intracerebral case of cryptococcoma in an immuno-spared woman in the Hospital Universitario de Santander and to discuss the most relevant topics of this pathology. Case report. A 24 years-old woman, coming to the service presenting generalized tonicclonicseizure, fixed upward gaze, sialorrhea and lost, without any data suggesting immunosupression. The computarizedtomography of skull demonstrates a mass of possible inflammatory vs. noeplasmic origin. After performing imaging the patient is taken to surgery for craniotomy with excisional biopsy. By means of hystological analysis the diagnosis of cerebralcriptococcoma is made, and antimycotic therapy is started, with favorable response. Actually the patient evidences good health, and no evidence of active disease. Conclusions. The presence of masses of criptococcal origin located at the centralnervous system, which origin is due to a chronic granulomatous reaction, is rarely reported; these appear in almost all cases in immunocompetent patients, in which there is of primary importance to discard all causes of cellular immune deficit. Also,the diagnosis of these injuries must be considered before the presence of intracerebral masses that show inflammatory characteristics