Assuntos
Síndromes de Imunodeficiência/genética , Tirosina Quinase da Agamaglobulinemia , Agamaglobulinemia/classificação , Agamaglobulinemia/enzimologia , Agamaglobulinemia/genética , Ataxia Telangiectasia/genética , Imunodeficiência de Variável Comum/genética , Proteínas do Sistema Complemento/deficiência , Proteínas do Sistema Complemento/genética , Citocinas/deficiência , Suscetibilidade a Doenças , Enzimas/deficiência , Feminino , Genes de Imunoglobulinas , Humanos , Hipergamaglobulinemia/genética , Imunidade Celular , Síndromes de Imunodeficiência/classificação , Síndromes de Imunodeficiência/fisiopatologia , Infecções/etiologia , Leucopenia/genética , Masculino , Proteínas Tirosina Quinases/deficiência , Proteínas Tirosina Quinases/genética , Imunodeficiência Combinada Severa/genética , Síndrome , Cromossomo X/genéticaRESUMO
STUDY OBJECTIVE: To determine sensitivity, specificity, positive predictive value, negative predictive value, and global diagnostic precision of hysteroscopic exploration in the diagnosis of endometrial hyperplasia and adenocarcinoma in women with abnormal uterine bleeding. DESIGN: Retrospective analysis. SETTING: University-affiliated hospital. PATIENTS: One thousand three hundred ninety-eight patients with abnormal uterine bleeding, 57.3% premenopausal and 42.6% postmenopausal. INTERVENTIONS: Diagnostic hysteroscopy and subsequent dilatation and curettage. MEASUREMENTS AND MAIN RESULTS: Endometrium was classified hysteroscopically as normal, atrophic, endometrial hyperplasia, and endometrial carcinoma. Histopathologic diagnosis was performed to determine the efficacy of hysteroscopy in diagnosing endometrial hyperplasia and adenocarcinoma. For endometrial hyperplasia in premenopausal women, sensitivity was 71.8%, specificity 96.4%, and global diagnostic precision 92.5%; in postmenopausal women, respective figures were 85. 1%, 100%, and 97.3%. For diagnosing adenocarcinoma in premenopausal patients, hysteroscopy was 100% sensitive, with specificity 99.4% and global diagnostic precision 99.5%; in postmenopausal women, respective figures were 100%, 99.4%, and 99.5%. CONCLUSIONS: In women with abnormal uterine bleeding, diagnostic hysteroscopy is a basic tool that allows precise diagnosis of endouterine lesions such as polyps and submucous myomas. It also is highly accurate for evaluating endometrial adenocarcinoma and hyperplasia.
