Hypertension Severity and Declines in Left Ventricular Ejection Fraction Among Women Receiving Adjuvant Chemotherapy for Breast Cancer (WF-97415 UPBEAT).

BACKGROUND: Hypertension is a risk factor for experiencing left ventricular ejection fraction (LVEF) declines during receipt of potentially cardiotoxic breast cancer (BC) treatment. We sought to determine whether the hypertension stage is associated with LVEF decline during BC treatment. METHODS: Across 24 centers, cardiac magnetic resonance measures of LVEF and brachial arterial blood pressure (BP) measurements were performed in women with stages I to III BC before and 3 months after initiating potentially cardiotoxic chemotherapy. Using multivariable analysis, we assessed in a blinded fashion the association between 3-month ΔLVEF and precancer treatment American Heart Association/American College of Cardiology stages of hypertension. RESULTS: Among 204 women, age averaged 56±1 years with 75% being White and 20% of Black race. Participants received anthracycline (45.6%), trastuzumab (22.5%), cyclophosphamide (52.9%), or paclitaxel (50%). After accounting for pretreatment LVEF, diabetes status, tobacco use, age, the number of antihypertensive medications, and body mass index, those with stage II hypertension experienced an LVEF decline of -2.89% ([95% CI, -0.69% to -5.19%]; P=0.01) relative to individuals with normal BP. Other stages saw nonsignificant declines relative to normal BP to elevated BP (-1.63% [95% CI, -0.62% to 3.88%]; P=0.16) and stage I hypertension (-0.94% [95% CI, -0.90% to 2.78%]; P=0.32). CONCLUSIONS: Compared with women receiving treatment for BC with normal BP, there is a stronger association of decline in LVEF in women with stage II hypertension relative to women with other hypertension stages. This raises the possibility that stage along with hypertension presence may be associated with an increased risk for the LVEF decline among women receiving potentially cardiotoxic chemotherapy for BC. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02791581 and NCT01719562.

Fluoride and its Implications on Oral Health: A Review.

This article aims to review the literature about the history of fluoride, its toxicity, prevalence, prevention, diagnosis, and management in oral healthcare practice. Fluoride is the cornerstone of oral health, playing a pivotal role in oral health. Fluoride can be administered topically or systemically. Topically, it is found in toothpaste, mouth rinses, and professional treatments such as fluoride varnish. These directly shield teeth from decay and strengthen the existing enamel. Systemically, fluoride is ingested through water, foods, or supplements, benefiting tooth development, especially in children. Nevertheless, responsible fluoride use is essential. Overexposure can lead to dental fluorosis, affecting tooth aesthetics. Consulting a dentist for personalized guidance on fluoride usage can help strike the right balance between oral protection and potential side effects, ensuring a radiant and healthy smile for life.

Comparative evaluation of retreatability of bioceramic sealer (BioRoot RCS) and epoxy resin (AH Plus) sealer with two different retreatment files: An in vitro study.

AIM: The aim of the study was to evaluate and compare the retreatability of BioRoot RCS and AH Plus sealer with two different retreatment file systems using cone-beam computed tomography (CBCT) for assessing the filling remnants. MATERIALS AND METHODS: A total of sixty mandibular premolars with single and oval root canals were prepared till size F3 and obturated with GP/AH Plus (Group 1) and GP/BioRoot RCS (Group 2). Canals were then retreated using two different retreatment file systems - ProTaper Universal Retreatment (PTUR) system and NeoEndo Retreatment system. The ability to re-establish working length (WL) and apical patency was recorded, and the percentage volume of residual filling material was evaluated using CBCT at the coronal, middle, and apical thirds. Data from the study were analyzed using one-way analysis of variance with Pearson's Chi-squared analysis and the Kruskal-Wallis test. RESULTS: No statistically significant difference was found in the amount of residual sealer (AH Plus and BioRoot RCS) after retreatment throughout the whole study (P > 0.05) at various root canal levels. Furthermore, the BioRoot RCS group retreated with the PTUR system showed a higher frequency of failure in re-establishing WL and regaining apical patency than the other groups. CONCLUSION: Complete removal of root canal sealers could not be achieved regardless of the type of sealer used and the retreatment technique employed. Furthermore, in clinical settings, the retreatability of novel BioRoot RCS may be deemed feasible.

New Approach in the Management of Vertical Root Fracture with the Help of Biodentine and CBCT.

INTRODUCTION: Vertical root fracture is a big challenge to dentists for its diagnosis and treatment. As the tooth presents poor prognosis, the most common treatment modality is extraction. One can save the tooth from extraction by the reconstruction of fracture fragments followed by intentional reimplantation. New treatment options have arrived for healing of the fracture site by hard tissue barrier formation with the help of bioceramic materials. Case Report. The present case report describes successful management of complete vertical root fracture of a maxillary left central incisor by trauma in a 35-year-old male with the help of Biodentine, a bonding agent, a fiber post, and dual-cure resin cement without tooth extraction, followed by all ceramic crowns. Up to two years of follow-up, there is no problem in the tooth, and radiographically, there is no radiolucency along the fracture line. Periodontal status and probing depth were within a normal physiological limit. CONCLUSION: Functional and aesthetic outcomes are achieved by combined therapy in the present case report.

Ventricular arrhythmia: A feature of tubercular myocarditis.

Tuberculat myocarditis is an extremely rare entity with few published reports. We report a 13 year old male who presented with ventriculat tachycardia. On evaluation he was observed to have MRI features and workup consistent with nodular variant of tubercular myocarditis. Child had fatal outcome on follow up.