[Subcortical structures of the brain and the behavior of white rats]. / Podkorkovye struktury mozga i povedenie belykh krys.

Conditioned food and defensive reflexes have been studied in white rats following bilateral injury of paleo-, archi-, neostriatum, substantia nigra and paleocortex. It has been shown that these deep structures play a role in the operational memory of animals.

[Conditioned reflexes following destruction of the deep structures of the brain]. / Uslovnye refleksy posle razrusheniia glubinnykh struktur mozga.

The role and the relative significance of paleo-, archi- and neostriatum as well as Corpus Luysii, substantia innominata, substantia nigra, nucl. ruber and the hippocampus, in the mechanism of purposeful behaviour of animals, were studied on cats and rats. It has been shown that the above structures, together with the cerebral cortex, take part in operational memory. The data obtained continue the evolutionary concept of L. A. Orbeli that in higher vertebrates with a well-developed cortex, the deeper brain structures do not lose their initial function, and together with the cortex, participate in the provision for the integrative activity of the brain.

[Participation of the basal ganglia in the mechanism of visual memory in the rat]. / Uchatie bazal'nykh gangliev v mekhanizmakh zritel'noi pamiati u krys.

Studies have been made of the effect of bilateral injury of paleo-, archi- and neostriatum, as well as that of the nucleus ruber on adaptive behaviour in albino rats. It was shown that injury of the basal structures of the brain results in disturbances of optimal visual choice of a food signal. The data obtained are discussed from a standpoint of disturbances in operative memory of visual signals. It is suggested that during evolutionary development, when the higher brain functions pass to neocortex, the basal ganglia do not loose their initial role in the higher analytical-synthetic activity.

[Effect of damage to the substantia nigra on conditioned reflex activity in animals]. / Vliianie povrezhdeniia chernoi substantsii na uslovnoreflektornuiu deiatel'nost' zhivotnykh.

Effects of the Substantia nigra injury on conditioned activities were studied on rats and cats by defensive and feeding methods, respectively. Bilateral injury of the Substantia nigra led to temporary disappearance of conditioned defensive and feeding motor reflexes, to prolongation of latency and duration of motor reaction. In cats the injury of the Substantia nigra produced a 30--40% decrease of the accuracy of food direction choice. Similar changes were observed following injury of the Nucleus caudatus head.

[Conditioned motor-alimentary reflexes in cats following ablation of the body of Luys]. / Uslovnye dvigatel'no-pishchevye refleksy pri povrezhdenii tela Liuisa u koshek.

Alimentary conditioned motor reflexes in cats were elaborated in special chambers. Subsequently, the subthalamic nucleus was damaged, first on one and then on the other side. After its unilateral destruction, temporary disturbance in the cat behaviour was observed disappearing within 2--3 weeks. Bilateral destruction of the subthalamic nucleus led to a stable disturbance in the reaction of choice of reinforcement side in conditions of uncertainty.

[The role of the pallidum in regulating cortical activity]. / Rol' palliduma v reguliatsii korkovoi aktivnosti

Bilateral ablation of the pallidum halves the duration of extinction of conditioned motor food reflexes and contributes to 30 to 50% extinction of the electro-defensive reflexes. Pallidum functional depression by potassium chloride or novacaine leads to a temporary total depression of conditioned motor food reflexes. Depending on the frequency of pallidum stimulation, synchronization or desynchronization of the cortical bioelectrical activity is observed. Ablation of the pallidum in anaesthetized cats results in a high amplitude and low-frequency cortical activity. Injection of large doses of potassium chloride into the pallidum results in a forced running forward which lasts 30 to 40 min. The pallidum is considreed as a structure controlling the cortex activity, which takes part in the mechanisms of sensory information processes in the course of adaptive behaviour.

[Conditioned alimentary motor reflexes in cats following destruction of the scorpula]. / Uslovnye dvigatel'nye pishchevye refleksy u koshek pri povrezhdenii skorpuly

Bilateral ablation of the putamen results in temporary disappearance of natural as well as artificial conditioned motor reflexes in cats. Further training is necessary for their reestablishment. Restored conditioned reflexes appear with a long latency. After partial bilateral ablation of the putamen, animals that have been trained not only to press a pedal, but also to make a choice between a right or left feeding tray, lose the latter ability. After the reestablishment of conditioned reflexes, the animal makes a correct choice of side only in 68--70% of cases. After total bilateral ablation of the putamen the animals lose artificial conditioned reflexes. The results suggest that the putamen has a close relation to the mechanisms of learning and memory.