1.
J Fr Ophtalmol
; 43(3): e107-e108, 2020 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31973973
2.
J Org Chem
; 66(18): 6141-50, 2001 Sep 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11529743
RESUMO
The 1alpha-fluoro A-ring phosphine oxide 1, a useful building block for fluorinated vitamin D analogues, was synthesized from (S)-carvone in 13 synthetic steps, and only five isolations, in 22% overall yield. In the key synthetic step, a highly selective palladium-catalyzed isomerization of dieneoxide 18 to dieneol 20 was achieved using an appropriately selected fluorinated alcohol as a catalytic proton source.