A profile of the members of FASEB societies: NIH awards, degrees, and institutional affiliations, 1999.

Data from the FASEB Directory of Members and NIH were used to develop a statistical profile of the members of FASEB Societies. For the U.S.-based scientists (exclusive of retired and student members), the most frequently reported degree was a research doctorate (69. 6%). A substantial fraction, however, reported medical degrees (19. 2%) or both research and medical degrees (8.0%). The majority of members of FASEB Societies listed academic affiliations in the directory. Industrial affiliations were reported, however, in 9.7% of the entries with smaller fractions listing associations with hospitals, independent research institutes, and government agencies. Just over one-fourth of the members of FASEB Societies were principal investigators on NIH research grants. These investigators received one-half of all NIH grants and nearly 60% of the RO1 grants.

Education and employment patterns of U.S. Ph.D.'s in the biomedical sciences.

During most of the 1970s and 1980s, the number of biomedical Ph.D.'s conferred in the United States was fairly constant. From 1987 to 1995, however, there was an increase of almost 50% in the number of biomedical Ph.D.'s awarded by U.S. institutions; nearly 70% of this increase can be accounted for by the increase in the number of noncitizens receiving a Ph.D. in the U.S. Although unemployment among U.S. citizens with biomedical Ph.D.'s is now extremely low--less than 2.0%--there have been some important changes in the job market for biomedical Ph.D.'s. The total number of biomedical scientists has grown, whereas the number of faculty positions has remained stable, causing a decline in faculty positions as a percentage of total employment for biomedical scientists. Jobs in industry have increased, and in the future might surpass academic jobs as the most prevalent form of employment for U.S. biomedical scientists.

Controlling hypertension. A research success story.

In the past 2 decades, deaths from stroke have decreased by 59% and deaths from heart attack by 53%. An important component of this dramatic change has been the increased use of antihypertensive drugs. This remarkable success resulted from broad-based and diverse research programs supported by the federal government, pharmaceutical companies, voluntary health agencies, and private foundations. It included basic research, drug development programs, epidemiologic studies, health surveys of US citizens, clinical research, and large-scale drug trials. Four of the categories of antihypertensive drugs in wide use--diuretics, beta-blockers, calcium antagonists, and angiotensin-converting enzyme inhibitors--emerged from widely different areas of investigation. In the beginning, the major breakthroughs that led to the development of these drugs were impossible to forecast, and their ultimate applications were impossible to predict. Although decreases in hypertension-related mortality are impressive, enthusiasm must be tempered because the mechanisms of hypertension are still incompletely understood and prevention is not yet possible. Continued research is needed to extend these advances.

NIH awards to individual members of FASEB societies: an initial examination.

Data from the FASEB Directory of Members were merged with information on NIH extramural awards to determine the percentage of FASEB society members who are principal investigators on NIH grants. Analysis of FY 1994 data reveals that FASEB society members earned 30.3% of all NIH awards and 38.8% of the R01 awards. Nineteen percent of the total membership of the nine FASEE societies were NIH principal investigators in FY 1994. This fraction rises to 21.6% when student and emeritus members are excluded. When adjustments are made for the fraction of the membership in government and industrial organizations, more than one-fourth of the academically based members are NIH principal investigators in FY 1994. Although the examination of principal investigators cannot document the full extent of NIH awards to members of FASEB societies (it was not possible to identify all of the scientists, postdoctoral fellows, and students supported through these grants), the study clearly delineates the magnitude of one essential part of the larger system of research support.

International distribution of dental materials publications and patents.

International patterns of research and development in the field of restorative dental materials were examined with data on publications (1981-85) and patents (1979-88). It was found that United States-based authors produced approximately one-half of all dental materials journal articles published worldwide, while US inventors had nearly the same share of the US dental materials patents. During the periods studied, the share of US patents in dental materials awarded to US inventors declined, while the share of US patents awarded to Japanese inventors rose. The role of the United States in research (as measured by journal articles) remained stable. Nations differed in the degree to which their researchers specialized in particular research areas. US-based authors and inventors were relatively over-represented in prosthetic materials and under-represented in dental cements, an area in which the British and the Japanese concentrated more of their activity. There was some, but not complete, agreement in the patterns of national specialization as indexed by patent and publication data. When dental materials data were compared with data for broader fields of science and technology, important differences were found. For publications, US-based authors displayed greater dominance in dental materials than in the fields of dentistry, chemistry, and materials science. US-based inventors' share of US dental materials patents was smaller than their share of all US patents. These analyses demonstrated that it was possible to use indicators derived from publication and patent data files to conduct insightful studies of a discrete specialty of science and technology.