Assuntos
Doença de Gaucher/tratamento farmacológico , Glucosilceramidase/efeitos adversos , Hepatomegalia/complicações , Hipertensão Pulmonar/induzido quimicamente , Hipóxia/complicações , Artéria Pulmonar/patologia , Adulto , Dilatação Patológica/complicações , Dilatação Patológica/tratamento farmacológico , Feminino , Doença de Gaucher/complicações , Doença de Gaucher/patologia , Hepatomegalia/tratamento farmacológico , Humanos , Hipóxia/tratamento farmacológico , Masculino , SíndromeRESUMO
PURPOSE: To assess the reliability and reproducibility of automated large-core breast biopsy. MATERIALS AND METHODS: A consortium of 20 institutions reported, in a standardized fashion, their core breast biopsy data. All biopsies were performed with "long-throw" (2.3-cm) automated core biopsy devices fitted with 14-gauge needles. Needle guidance was accomplished by means of either a dedicated, stereotaxic device, in which the patient lies in the prone position, or high-frequency electronically focused ultrasound equipment. RESULTS: The data in 6,152 lesions were gathered. Clinical or surgical follow-up was available in 3,765 lesions; 1,363 of these lesions were subsequently surgically excised, and the core histologic study showed cancer in 910 lesions, mammary intraepithelial neoplasia in 173 lesions, and benign disease in 280 lesions. In these 280 lesions, there were 15 false-negative core biopsies. CONCLUSION: The data show that percutaneous large-core breast biopsy is a reproducible and reliable alternative to surgical biopsy.
Assuntos
Biópsia por Agulha , Mama/patologia , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/diagnóstico por imagem , Feminino , Humanos , Radiografia Intervencionista , Reprodutibilidade dos Testes , Estudos Retrospectivos , Técnicas Estereotáxicas , Ultrassonografia de IntervençãoRESUMO
The appearance of breast attenuation artifacts is described as the artifacts occur with single photon emission computed tomography (SPECT) imaging of the heart using TI-201 thallous chloride.
Assuntos
Neoplasias da Mama/diagnóstico por imagem , Coração/diagnóstico por imagem , Radioisótopos , Tálio , Tomografia Computadorizada de Emissão , Feminino , HumanosRESUMO
Monoclonal antibodies (MoAbs) against carcinoembryonic antigen were successfully radiolabeled with 111In, and the radiopharmaceutical was characterized in vitro and in normal and tumor-bearing mice. The 111In-MoAb proved to be stable in vitro and in vivo under normal conditions, although instability could be induced in vitro with large quantities of iron-free transferrin. Animal distribution studies with 111In-MoAb demonstrated tumor localization superior to 67Ga and pharmacokinetics that were highly similar to those of endogenously labeled 75Se-MoAb. The 111In-MoAb followed first-order kinetics and fit a two-compartmental model when studied in nude mice bearing human colon tumors known to express carcinoembryonic antigen. Significant quantities of radiolabel appeared in tissues other than tumor, with liver and skin having the highest concentrations. Sufficient tumor/background ratios were formed for scanning purposes. The data indicate that 111In-MoAb may prove to be effective as a radiopharmaceutical for tumor imaging.
