[Neuronet restructuring in focal and generalized epilepsy according to resting state fMRI]. / Neirosetevye perestroiki pri fokal'noi i generalizovannoi épilepsii po dannym fMRT pokoia.

AIM: To compare neuronet restructuring in focal and generalized epilepsy. MATERIAL AND METHODS: Seventy-seven patients, aged from 18 to 65 years, with the diagnosis of epilepsy, including 63 patients with focal epilepsy and 14 with generalized epilepsy, were examined. A control group included 23 healthy people. Neuronet restructuring was studied using fMRI. RESULTS AND CONCLUSION: According to resting state fMRI, there were between-group differences in spatial organization (activity map) of the brain structures as well as in the results of cross-correlation analysis of interaction maps of resting-state networks. It has been concluded that functional restructuring in connectomes in focal and generalized epilepsy have the opposite patterns of disorganization (toward increase or decrease) in most structures studied though there are structures with the same direction of connectivity changes.

[Subcortical laminar heterotopia 'double cortex syndrome']. / Podkorkovaia laminarnaia geterotopiia (sindrom 'dvoinoi kory').

This article presents a clinical case of a 29-year-old patient with 'Double cortex syndrome' with epilepsy, intellectual and mental disorders. Subcortical band heterotopia is a rare disorder of neuronal migration. Such patients typically present with epilepsy and variable degrees of mental retardation and behavioral and intellectual disturbances. The main diagnostic method is magnetic resonance imaging (MRI).

[Clinical and neurovisualization characteristics of apathetic depression]. / Klinicheskie i neirovizualizatsionnye kharakteristiki apaticheskoi depressii.

AIM: To study apathetic depression first diagnosed at late age and identify its relation to cognitive and social dysfunction as well as to morphological and functional changes in the brain. MATERIAL AND METHODS: Thirty-two patients at the age above 60 years with newly diagnosed depressive episode and 15 healthy age-matched volunteers were included in the study. All patients were divided into two groups by the score on the Apathy scale (AS): >14 - depression with apathy (n=21), <14 - depression without apathy (n=11). Patients were examined using psychometric methods (HAMD, GDS, AS, SHAPS, SF-36, MoCA-test), neuroimaging (MRI scanner with a magnetic field strength of 1.5 Tesla - EXCEL ART Vantage Atlas-X, Toshiba, Japan) and statistical data analysis. RESULTS AND CONCLUSION: Apathy component in clinical depression reflects a tendency towards the increase in depression severity and cognitive deterioration that results in the substantial lowering of quality of life and correlates with cerebrovascular changes, decrease in gray and white matter volume and mean cortical thickness of large hemispheres.

[Neuroimaging of functional abnormalities in apathy]. / Neirovizualizatsiia funktsional'nykh narushenii pri apatii.

Apathy is a common comorbid condition in neurologic and somatic disorders (Alzheimer's disease, Parkinson's disease, multiple sclerosis, frontotemporal dementia, senile dementia, HIV) and a symptom of many psychiatric disorders. Neurophysiologic research in this area aims to examine the specific features to differentiate the apathy from main disorder. This paper reviews neuroimaging studies of functional abnormalities in apathy.

[Neuroanatomical age-related changes in apathy].

The introduction of new instrumental methods, in particular neuroimaging techniques, in academic studies and clinical practice allowed to identify neuroanatomical and functional correlates of different clinical syndromes. Authors summarized the results of magnetic-resonance tomography (MRI) and one-photon emission computed tomography (OPECT) studies of apathy of old-age developed in the structure of different neurological and mental diseases. The literature over that last two decades was reviewed