RESUMO
It is suggested on the ground of the present study that in a number of cases of duodenal ulcer it is an immunoglobulin of the class IgG which, as a stimulating factor, accounts for overproduction of gastric HCl. This immunoglobulin takes effect by direct attachment to the parietal cells.
Assuntos
Úlcera Duodenal/imunologia , Suco Gástrico/metabolismo , Mucosa Gástrica/imunologia , Imunoglobulina G/metabolismo , Animais , Úlcera Duodenal/fisiopatologia , Mucosa Gástrica/efeitos dos fármacos , Gastrinas/metabolismo , Humanos , Cooperação Linfocítica , Ratos , Taxa Secretória/efeitos dos fármacosAssuntos
Digoxina/sangue , Hepatite/sangue , Doença Aguda , Digoxina/metabolismo , Hepatite/metabolismo , HumanosRESUMO
The intrinsic factor activity of powdered hog duodenal mucosa was confirmed by measurements of the absorption of labelled vitamin B 12 (Schilling-test) in 7 cases of Addisonian pernicious anaemia. In view of the fact that, according to earlier studies of the authors based on a bacteriological test, human duodenal juice also exhibits an intrinsic factor activity, it is suggested that the duodenal intrinsic factor may be involved in the pathogenesis of pernicious anaemia. The results of the Schilling-test are critically reviewed in the light of recent published evidence.
